Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 4, 2025
Naringenin
(NAR)
possesses
various
pharmacological
activities
including
antioxidant,
anti-inflammatory,
and
hepatoprotective
effects.
However,
its
therapeutic
efficacy
is
limited
by
hydrophobic
crystalline
nature.
This
study
aimed
to
investigate
the
potential
molecular
mechanisms
of
NAR
efficiently
loaded
into
cationic
nanoparticles
(NP-NAR)
for
treating
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
in
a
mouse
model.
The
results
demonstrated
that
NP-NAR
effectively
ameliorated
lipid
metabolism
dysbiosis,
oxidative
stress,
insulin
resistance,
inflammation
MASLD
mice.
Transcriptomic
analysis
data
revealed
promoted
fatty
acid
oxidation
via
activation
PPAR
signaling
pathway,
reduced
hepatic
uptake
lipogenesis
inhibiting
expressions
key
genes
CD36,
ACC,
FASN.
Moreover,
modulated
cholesterol
classical
bile
synthesis
pathway.
16
S
rDNA
gene
sequencing
disbalanced
gut
microbiota
mice,
whereas
treatment
statistically
reversed
abundance
changes
several
intestinal
bacteria
at
phylum
genus
levels,
which
partly
contributed
balance
metabolite
production,
short-chain
acids.
In
conclusion,
these
findings
suggest
may
be
promising
candidate
obesity-associated
MASLD,
offering
new
insight
underlying
NAR's
against
MASLD.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 3, 2025
Obesity
has
become
a
widespread
metabolic
disorder,
marked
by
its
escalating
global
prevalence.
Puerarin,
extracted
from
Pueraria
lobata,
one
of
the
traditional
homologies
medicine
and
food,
demonstrates
anti-obesity
properties.
Nonetheless,
mechanisms
through
which
puerarin
exerts
effects
remain
to
be
elucidated.
This
study
seeks
highlight
potential
application
in
obesity
management
investigate
underlying
involving
gut
microbiota
lipid
metabolism.
Different
doses
were
administered
high-fat
diet
mice
model,
structure
composition
analyzed
using
16S
rRNA
sequencing.
Q-PCR
evaluated
expression
genes
related
Our
findings
demonstrate
that
treatment
significantly
reduces
body
weight
epithelial
beige
fat
mass.
Furthermore,
alters
microbiota,
is
associated
with
Additionally,
upregulates
gene
expression,
fatty
acid
transport
protein
5
(FATP5)
hormone-sensitive
lipase
(HSL),
adipose
triglyceride
(ATGL)
adipose.
Puerarin
ameliorating
changing
enhances
triglycerides
hydrolysis
within
tissue.
provides
novel
perspective
on
as
dietary
supplement
for
obesity.
Journal of Lipid Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100803 - 100803
Published: April 1, 2025
In
obesity,
adipose
tissue
(AT)
expansion
is
accompanied
by
chronic
inflammation.
Altered
lipid
composition
in
the
visceral
or
gonadal
white
AT
(GWAT)
directly
drive
macrophage
(ATM)
accumulation
and
activation
to
a
proinflammatory
phenotype.
Sex
steroid
hormones
modulate
vs
subcutaneous
that
correlates
with
metabolic
syndrome,
especially
men
post-menopausal
women
who
are
more
prone
abdominal
obesity.
Prior
studies
demonstrated
sex
differences
GWAT
species
HFD-fed
mice,
but
role
of
still
unclear.
We
hypothesized
hormone
alterations
gonadectomy
(GX)
would
further
impact
obese
GWAT.
Untargeted
lipidomics
identified
phospholipids,
sphingolipids,
sterols,
fatty
acyls,
saccharo-lipids
prenol-lipids.
Males
had
significantly
precursor
acids
(palmitic,
oleic,
linoleic
arachidonic
acid)
than
females
GX
mice.
Targeted
for
oxylipins
male
female
stromal
vascular
fraction
(SVF)
higher
omega-6
omega-3
free
acid
profile
males
polyunsaturated
(PUFAs)-derived
prostaglandins,
thromboxanes
leukotrienes.
Both
SVF
showed
increased
levels
(AA)
derived
compared
their
lean
counterparts.
Bulk
RNA
sequencing
sorted
ATMs
highlighted
diet
PUFA
oxylipin
metabolism
genes.
These
findings
sexual
dimorphism
both
stored
mediators
emphasize
sex-differences
pathways
inflammation
responses
disease
risk
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 15, 2025
Intricate
interactions
between
immune
cells
and
cytokines
define
psoriasis,
a
chronic
inflammatory
skin
condition
that
is
immunological-mediated.
Cytokines,
including
interleukins
(ILs),
interferons
(IFNs),
tumor
necrosis
factors
(TNFs),
chemokines,
transforming
growth
factor-β
(TGF-β),
are
essential
for
controlling
cellular
activity
immunological
responses,
maintaining
homeostasis
contributing
to
the
pathogenesis
of
psoriasis.
These
molecules
modulate
microenvironment
by
either
promoting
or
suppressing
inflammation,
which
significantly
impacts
therapeutic
outcomes.
Recent
research
indicates
treatment
strategies
targeting
chemokines
have
significant
potential,
offering
new
approaches
regulating
system,
inhibiting
progression
reducing
adverse
effects
traditional
therapies.
This
review
consolidates
current
knowledge
on
cytokine
chemokine
signaling
pathways
in
psoriasis
examines
their
significance
treatment.
Specific
attention
given
like
IL-17,
IL-23,
TNF-α,
underscoring
necessity
innovative
therapies
these
address
processes.
emphasizes
principal
part
-pathological
process
explores
challenges
opportunities
they
present
intervention.
Furthermore,
we
examine
recent
advancements
targeted
therapies,
with
particular
focus
monoclonal
antibodies,
ongoing
clinical
trials.
