Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 185, P. 117936 - 117936
Published: March 8, 2025
Language: Английский
Annals of Medicine and Surgery, Journal Year: 2025, Volume and Issue: 87(3), P. 1259 - 1263
Published: Feb. 27, 2025
Introduction: Urinary tract infections (UTIs) cause a major burden in hospitals, mainly among the elderly, where they can increase morbidity and mortality are common of delirium. We aim to study UTIs, their inflammatory markers, microbiology cultures Syria. Methods: This is cross-sectional conducted two hospitals Damascus, Syria, on patients admitted for UTIs urosepsis who had positive urine cultures. Our included comorbidities such as diabetes high blood pressure. Urine symptoms, presentation were used determine diagnosis UTI/urosepsis. Having an indwelling catheter or other abnormalities was also included. Results: 120 patients, 66 (55%) being females. The mean age sample 59.5 years (SD = 11.4), with 52.2% above 60 age. yielded 64 (53.3%) Escherichia coli , which extended-spectrum beta-lactamases (ESBL) 16 (13.3%), 23 (19.2%) Klebsiella pneumoniae . Diabetes significantly associated having sepsis UTI ( P < 0.049). Older ages, higher C-reactive protein neutrophils ratio compared just UTI. However, catheter, urological anatomical recurrent not chance urosepsis. Conclusion: problem ESBL high. need better early indicators face this growing resistance improve outcomes.
Language: Английский
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Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: Feb. 28, 2025
Mpox (Monkeypox) is a highly contagious viral disease that can be transmitted from animal-to-human or human-to-human through intimate contact, caused by the monkeypox virus (MPXV), which an enveloped double-stranded DNA belongs to genus Orthopoxvirus, Poxviridae family, and subfamily Chordopoxvirinae. cases were previously only reported in West Central Africa, however recent times non-endemic countries including Saudi Arabia (SA) also confirmed cases. The first laboratory-confirmed human case SA was on 14 July 2022, since then number of have been WHO SA. These observed among individuals with history visiting European Union countries. not at risk importation owing travel such countries, but there are various other factors geographic proximity African continent, trade exotic animals, massive inflow tourists. Therefore, government health authorities should continue collaborate international organizations prevent, manage monitor potential risks most entry points highways, seaports, airports ensuring adherence hygiene protocols, vaccinations, screenings. There range diagnostic tests currently available used confirm infections, real-time PCR, loop-mediated isothermal amplification, serological testing, clustered regularly interspaced short palindromic repeat-CRISPR-associated protein (CRISPR-Cas)-based systems, whole-genome sequencing, electron microscopy, isolation culture. no approved treatment specifically for Mpox, multiple antiviral agents smallpox found useful management outbreaks, as- trifluridine, brincidofovir, tecovirimat, cidofovir. aim this review provide valuable insights regarding virology, pathogenesis, epidemiology, transmissions, clinical presentation, tests, prophylactic measures therapeutic options perspective. Moreover, side-by-side discussion global trend scenarios has provided comparison further improvement against
Language: Английский
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Annals of Medicine and Surgery, Journal Year: 2025, Volume and Issue: 87(4), P. 1969 - 1981
Published: Feb. 28, 2025
Background: Acute respiratory distress syndrome (ARDS) is a common severe lung disease with high morbidity and mortality. Yi-Qi-Xuan-Fei-Hua-Tan decoction (YQXFHT) based on the classical formula of Ma-Xing-Shi-Gan flavor addition. Methods: First, global view potential compound-target-pathway network pharmacology was constructed to provide preliminary understanding active compounds. Subsequently, in vivo efficacy YQXFHT verified mouse model. Meanwhile, metabolic mechanism treatment ARDS explored using corresponding metabolomic profiles. Results: Five components 10 core targets for were obtained through pharmacological studies. Potential activities include isorhamnetin, jaranol, medicarpin, quercetin, mandneol, STAT3, PIK3CA, PIK3CD, NRAS, AKT1, PTPN11, JAK1, EGFR, IL-6, CTNNB1. Besides, pathways analyzed by Kyoto Gene Genome Encyclopedia enrichment analysis, mainly including estrogen, IL-17, TNF, FoxO, PI3k-Akt, HIF-1 signaling pathways, etc. It shown that docking model between target its stable molecular docking. Finally, metabolomics, it concluded can be activated unsaturated fatty acid synthesis, linoleic metabolism, lysine degradation, arginine proline drug metabolism-cytochrome P450 exert effects ARDS. Conclusion: This study highlighted reliability validity metabolomics pharmacology-based approach identified validated complexes natural elucidate therapeutic mechanisms
Language: Английский
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Annals of Medicine and Surgery, Journal Year: 2025, Volume and Issue: 87(4), P. 1918 - 1923
Published: March 7, 2025
Background: Global surgery (GS) aims to improve access timely, quality, and affordable surgical care worldwide, yet it remains underrepresented in public health education. Objective: This cross-sectional study assessed the awareness knowledge of GS among 242 professionals. Methods results: Data collected via a self-structured questionnaire using SPSS 25 revealed significant gender age diversity, with majority being young professionals (76.4% aged 20–29). Most participants (71.5%) held master’s degree, 55% had 1–5 years experience. While 60% were familiar term “Global Surgery,” considerable portion lacked comprehensive understanding. Participants emphasized need integrate into curricula through faculty development, practical training, scholarships, research collaborations. Conclusion: These strategies aim bridge gap enhance role global health. Despite essential for addressing disease burden, inaccessible many LMICs due systemic barriers. underscores importance fostering international partnerships promoting multidisciplinary approach access, ultimately contributing better outcomes globally.
Language: Английский
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Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 185, P. 117936 - 117936
Published: March 8, 2025
Language: Английский
Citations
0