The role of AMPKα subunit in Alzheimer's disease: In-depth analysis and future prospects DOI Creative Commons

Lingqiong Xia,

Jianhua Chen, Juan Huang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e34254 - e34254

Published: July 1, 2024

The AMP-activated protein kinase α (AMPKα) subunit is the catalytic in AMPK complex, playing a crucial role activation. It has two isoforms: AMPKα1 and AMPKα2. Emerging evidence suggests that AMPKα exhibits subtype-specific effects Alzheimer's disease (AD). This review discusses of pathogenesis AD, including its impact on β-amyloid (Aβ) pathology, Tau metabolic disorders, inflammation, mitochondrial dysfunction, inflammasome pyroptosis. Additionally, it reviews distinct roles isoforms, AMPKα2, which may provide more precise targets for future drug development AD.

Language: Английский

The role of AMPKα subunit in Alzheimer's disease: In-depth analysis and future prospects DOI Creative Commons

Lingqiong Xia,

Jianhua Chen, Juan Huang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e34254 - e34254

Published: July 1, 2024

The AMP-activated protein kinase α (AMPKα) subunit is the catalytic in AMPK complex, playing a crucial role activation. It has two isoforms: AMPKα1 and AMPKα2. Emerging evidence suggests that AMPKα exhibits subtype-specific effects Alzheimer's disease (AD). This review discusses of pathogenesis AD, including its impact on β-amyloid (Aβ) pathology, Tau metabolic disorders, inflammation, mitochondrial dysfunction, inflammasome pyroptosis. Additionally, it reviews distinct roles isoforms, AMPKα2, which may provide more precise targets for future drug development AD.

Language: Английский

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