Impacts of supplementation with milk proteins on inflammation: a systematic review and meta-analysis

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

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A Genetic and Environmental Analysis of Inflammatory Factors in Chronic Widespread Pain Using the TwinsUK Cohort

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 155 - 155

Published: Jan. 21, 2025

Chronic widespread musculoskeletal pain (CWP), a significant health issue affecting individuals and society, is often diagnosed as part of fibromyalgia but not generally considered inflammatory. This study investigated the relationship between blood-based inflammatory factors CWP in 904 from TwinsUK cohort. Participants, free major conditions, completed questionnaires to assess CWP. Plasma samples were analysed using Olink panel, alongside assays for C-reactive protein (CRP) Apolipoproteins A1 B. No associations observed after adjusting multiple testing. Twin modelling revealed heritability both factors, with genetic covariance several factors. Additive Bayesian network suggested that any association mediated by body mass index (BMI). These findings emphasize complexity its potential reliance on beyond inflammation, such BMI, which strongly correlates CRP other markers. Future research should explore additional molecular, genetic, environmental contributors variability investigate clinical or covariates may obscure relationships providing more comprehensive understanding this multifaceted condition.

Language: Английский

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Fabry Disease and Inflammation: Potential Role of p65 iso5, an Isoform of the NF-κB Complex

Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 230 - 230

Published: Feb. 6, 2025

Fabry disease (FD) is an X-linked lysosomal storage disease, caused by mutations in the GLA gene on X chromosome, resulting a deficiency of enzyme α-GAL. This leads to progressive accumulation Gb3 cells, causing multi-systemic effects. FD has been classified as subgroup autoinflammatory diseases. NF-κB family ubiquitous and inducible transcription factors that play critical roles inflammation, which p65/p50 heterodimer most abundant. The glucocorticoid receptor (GR) represents physiological antagonists inflammation process. A novel spliced variant p65, named p65 iso5, can bind dexamethasone, enhancing GR activity, found. study investigates potential role iso5 subjects with FD. We evaluated peripheral blood mononuclear cells (PBMCs), from over 100 patients, mRNA level, protein expression. results showed significantly lower expression levels compared controls. These findings, along ability dexamethasone regulation response opposite way strongly suggest involvement inflammatory

Language: Английский

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Cordycepin attenuates NLRP3/Caspase-1/GSDMD-mediated LPS-induced macrophage pyroptosis

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 14, 2025

Pyroptosis, a form of programmed cell death driven by the NLRP3 inflammasome, is key contributor to inflammation in various diseases. This study aimed investigate anti-inflammatory mechanisms cordycepin, focusing on its role macrophage pyroptosis. Molecular docking analysis was performed evaluate binding affinity cordycepin pyroptosis-related proteins, including NLRP3, Caspase-1, and GSDMD. RAW264.7 cells were pre-treated with assess effects Key measurements included reactive oxygen species (ROS) levels, xanthine oxidase (XO) activity, expression Additionally, lactate dehydrogenase (LDH) release, interleukin (IL)-1β IL-18 levels culture supernatant, rates evaluated using Hoechst 33342/PI dual staining. The results demonstrated that exhibits strong for Cordycepin pre-treatment significantly reduced ROS XO inhibited cleaved-Caspase-1, cleaved-GSDMD, decreased pyroptosis-associated inflammatory cytokines IL-1β IL-18, along Caspase-1 activity. Furthermore, pyroptosis rate. In conclusion, inhibits reducing suppressing production, regulating molecules NLRP3/Caspase-1/GSDMD pathway. These findings provide experimental basis potential development as novel agent.

Language: Английский

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Navigating COVID-19: advancements in therapeutics and viral filtration technologies for Today's challenges and tomorrow's solutions

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106741 - 106741

Published: Feb. 1, 2025

Language: Английский

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Immune-Boosting Potential of Food Bioactives

Published: Jan. 1, 2025

Language: Английский

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Interaction between 3-SNP genetic risk score and dietary fats intake on inflammatory markers among overweight and obese women

Journal of Diabetes & Metabolic Disorders, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 14, 2025

Language: Английский

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The Impacts of Seasonal Factors on Psoriasis

Experimental Dermatology, Journal Year: 2025, Volume and Issue: 34(3)

Published: March 1, 2025

ABSTRACT Psoriasis is a chronic inflammatory skin condition driven by immune system dysfunction, genetic predisposition and environmental factors. Patients with psoriasis experience well‐known clinical phenomenon of ‘winter severity summer relief’, in which seasonal factors play critical roles the onset progression psoriasis. These include temperature, humidity, infection, light exposure psychological stress. Seasonal changes temperature humidity can compromise barrier function exacerbate responses, thereby worsening symptoms. Notably, during winter, decreased leads to reduced vitamin D (VD) levels, reaching their lowest levels from late winter early spring. This decline VD associated increased disease activity, greater more frequent flare‐ups patients During influenza Streptococcus pneumoniae infections are prevalent, further Moreover, conditions trigger or intensify feelings depression, may adversely affect through brain–skin axis. In this comprehensive review, we thoroughly examined influence on incidence, recurrence By clarifying these complex relationships, aimed support future development personalised effective treatment management strategies for

Language: Английский

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The Role of IL-23 in the Development of Inflammatory Diseases

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 347 - 347

Published: March 27, 2025

Interleukin-23 is crucial in the initiation and progression of certain inflammatory disorders. As a key cytokine, IL-23 involved differentiation activation Th17 cells, which play role broad spectrum diseases. This review examines molecular mechanisms through contributes to pathogenesis conditions including psoriasis, rheumatoid arthritis, bowel disease, multiple sclerosis. By elucidating significant inflammation, this underscores its importance as therapeutic target for managing conditions, with particular emphasis on current emerging biologic treatments.

Language: Английский

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Developing and regenerating a sense of taste

Current topics in developmental biology/Current Topics in Developmental Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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