Heliyon,
Journal Year:
2024,
Volume and Issue:
11(1), P. e41534 - e41534
Published: Dec. 27, 2024
The
aim
of
this
paper
is
to
discover
differentially
expressed
genes
related
ferroptosis
(DEFRGs)
in
patients
with
ST-segment
elevation
myocardial
infarction
(STEMI)
and
construct
a
reliable
prognostic
signature
that
incorporates
key
DEFRGs
easily
accessible
clinical
factors.
We
did
systematic
review
Gene
Expression
Omnibus
datasets
picked
SE49925,
GSE60993,
GSE61144
for
analysis.
applied
GEO2R
find
overlapped
them
among
the
datasets.
performed
functional
enrichment
analysis
explore
their
biological
functions.
built
an
optimal
model
least
absolute
shrinkage
selection
operator
(LASSO)
penalized
Cox
proportional
hazards
regression.
tested
value
survival
analysis,
ROC
curve,
decision
curve
nomogram.
also
confirmed
externally
plasma
samples
from
our
center's
patients.
A
combining
three
overexpressed
(ACSL1,
ACSL4,
TSC22D3)
two
variables
(serum
creatinine
level,
Gensini
score)
was
established.
effectively
classified
into
low-
high-risk
groups.
Survival
DCA
showed
its
robust
predictive
performance
utility
within
years
after
onset
disease.
external
validation
cohort
significant
difference
major
adverse
cardiovascular
events
(MACEs)
between
This
study
revealed
STEMI
developed
integrates
gene
expression
levels
factors
stratifying
predicting
risk
MACEs.
Journal of Biochemical and Molecular Toxicology,
Journal Year:
2025,
Volume and Issue:
39(5)
Published: April 28, 2025
ABSTRACT
Heart
failure
is
a
common
heart
disease
and
cause
of
death
globally
which
caused
by
structural
functional
abnormalities.
circRNA_0030042
newly
discovered
circRNA
that
derived
from
its
host
gene
forkhead
box
O1
(FOXO1).
However,
the
role
in
not
revealed.
This
study
aims
to
explore
progression.
In
this
study,
AC16
cell
model
was
induced
medium
containing
200
µM
H
2
O
.
markedly
elevated
peripheral
blood
patients
with
‐induced
cells.
Knockdown
hsa‐circRNA_0030042
repressed
apoptosis
cells
facilitated
viability
Besides,
knockdown
decreased
iron
ion
level,
ferroptotic
markers
ROS
MDA
levels,
increased
GSH
ferroptosis‐associated
proteins
SLC7A11
GPX4
protein
expressions
addition,
could
interact
miR‐568,
negatively
modulate
miR‐568
expression
also
targeted
PRG4,
modulated
PRG4
expression.
positively
regulated
via
Furthermore,
promoted
proliferation,
miR‐568/PRG4
pathway.
Finally,
transverse
aortic
constriction
(TAC)
mice
were
conducted
thoracotomy
procedure
under
microscope.
vivo
experiments
showed
mmu‐circRNA_0030042
ameliorated
cardiac
dysfunction,
myocardial
injury
cTnI,
CK‐MB
BNP
relieved
histopathological
damage,
tissue,
GSH,
tissue
TAC
mice.
Therefore,
attenuated
Cell Biochemistry and Function,
Journal Year:
2024,
Volume and Issue:
42(2)
Published: March 1, 2024
Abstract
Autophagy
is
a
process
in
which
cells
degrade
intracellular
substances
and
play
variety
of
roles
cells,
such
as
maintaining
homeostasis,
preventing
cell
overgrowth,
removing
pathogens.
It
highly
conserved
during
the
evolution
eukaryotic
cells.
So
far,
study
autophagy
still
hot
topic
field
cytology.
Ferroptosis
an
iron‐dependent
form
death,
accompanied
by
accumulation
reactive
oxygen
species
lipid
peroxides.
With
deepening
research,
it
has
been
found
that
ferroptosis,
like
autophagy,
involved
occurrence
development
cardiovascular
diseases.
The
relationship
between
ferroptosis
complex,
association
two
disease
remains
to
be
clarified.
This
article
reviews
mechanism
their
correlation,
discusses
them
diseases,
expected
provide
new
important
treatment
strategies
for
World Journal of Cardiovascular Diseases,
Journal Year:
2024,
Volume and Issue:
14(04), P. 195 - 216
Published: Jan. 1, 2024
Background:
Emerging
evidence
has
recognized
that
anemia
and
iron
deficiency
are
recurrent
comorbidities
in
chronic
heart
failure
(HF)
several
trials
have
established
administration
improves
myocardial
asset
clinical
scenario
HF.
Purpose:
Recent
acquisitions
suggest
represents
a
concrete
bias
the
pathogenetic
mechanism
of
HF,
so
we
investigated
putative
role
hepcidin/ferroportin
axis
cardiovascular
setting
to
advocate
novel
pharmacological
approaches.
Methods:
Here,
after
an
excursus
on
metabolism,
first
reviewed
ongoing
studies
targeted
compounds.
Then,
summarize
large
interventional
conducted
patient
suffering
from
HF
which
tested
effects
drugging
regard
QoL,
hospitalizations
death.
Results:
Novel
compounds
such
as
hepcidin
agonist
(PTG
300),
synthetic
human
(LJPC-401)
anti
FPN
(Vamifeport)
overloaded
patients,
while
blocker
(PRS-080)
is
under
investigation
anemic
patients.
Noteworthy,
insights
could
arise
results
Phase
IV
study
regarding
modification
pathway
cohort
patients
(n
=
1992)
by
sodium
glucose
cotransporter
2
inhibitors.
To
date,
highlight
beneficial
effect
latest
evidences
consider
level
biomarker
cardiac
injury
atherosclerosis.
Conclusions:
We
data
will
therapies
for
diagnosis,
prognosis
therapy
transferable
selected
failed
DNA and Cell Biology,
Journal Year:
2024,
Volume and Issue:
43(10), P. 492 - 509
Published: Oct. 1, 2024
Cardiovascular
and
cerebrovascular
diseases
(CCVDs)
significantly
contribute
to
global
mortality
morbidity
due
their
complex
pathogenesis
involving
multiple
biological
processes.
Ferroptosis
is
an
important
physiological
process
in
CCVDs,
manifested
by
abnormal
increase
intracellular
iron
concentration.
MiRNAs,
a
key
class
of
noncoding
RNA
molecules,
are
crucial
regulating
CCVDs
through
pathways
like
glutathione-glutathione
peroxidase
4,
glutamate/cystine
transport,
metabolism,
lipid
other
oxidative
stress
pathways.
This
article
summarizes
the
progress
miRNAs'
regulation
on
aiming
provide
insights
for
diagnosis
treatment
CCVDs.
