A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer’s disease

Future Science OA, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 31, 2025

Alzheimer's disease is a developing public health concern in aging communities that affects sizable section of the global population. The risk increases with age; it one-third males and two-thirds women. This research attempts to assess effect nano-selenium thymoquinone on Nrf2 gene expression levels (AD). There were five identical groups 50 albino male rats: control group was healthy; an AD positive group; received (5 mg/kg); (2 both. duration treatment 4 weeks. brain tissues evaluated using real-time PCR. mean nano-selenium-treated rats, thymoquinone-treated rats given both treatments all increased significantly compared no treatment. study showed elevated AD.

Language: Английский

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A Systematic Review on Advances in Management of Oxidative Stress-Associated Cardiovascular Diseases

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 923 - 923

Published: July 29, 2024

Oxidative stress plays a significant role in the pathogenesis of cardiovascular diseases, such as myocardial ischemia/reperfusion injury, atherosclerosis, heart failure, and hypertension. This systematic review aims to integrate most relevant studies on oxidative management diseases. We searched literatures PubMed database using specific keywords. put emphasis those manuscripts that were published more recently higher impact journals. reviewed total 200 articles. examined current managements including supplements like resveratrol, vitamins C E, omega-3 fatty acids, flavonoids, coenzyme-10, which have shown antioxidative properties potential benefits. In addition, we pharmacological treatments newly discovered antioxidants nanoparticles show effects targeting pathways. Lastly, biomarkers, soluble transferrin receptor, transthyretin, cystatin evaluating antioxidant status identifying risk. By addressing mechanisms, this paper emphasizes importance maintaining balance between oxidants progression is registered with International Platform Registered Systematic Review Meta-analysis Protocols (INPLASY), registration # INPLASY202470064.

Language: Английский

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Modulation of Oxidative Stress and Neuroinflammation by Cannabidiol (CBD): Promising Targets for the Treatment of Alzheimer’s Disease

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(5), P. 4379 - 4402

Published: May 6, 2024

Alzheimer’s disease (AD) is a progressive neurodegenerative and the most common form of dementia globally. Although direct cause AD remains under debate, neuroinflammation oxidative stress are critical components in its pathogenesis progression. As result, compounds like cannabidiol (CBD) being increasingly investigated for their ability to provide antioxidant anti-inflammatory neuroprotection. CBD primary non-psychotropic phytocannabinoid derived from Cannabis sativa. It has been found beneficial outcomes variety medical conditions gaining increasing attention potential therapeutic application AD. not psychoactive lipophilic nature allows rapid distribution throughout body, including across blood–brain barrier (BBB). also possesses anti-inflammatory, antioxidant, neuroprotective properties, making it viable candidate treatment. This review outlines CBD’s mechanism action, role AD, effectiveness limitations preclinical models

Language: Английский

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Utilization of Cannabidiol in Post-Organ-Transplant Care

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 699 - 699

Published: Jan. 15, 2025

Cannabidiol (CBD) is one of the major phytochemical constituents cannabis, Cannabis sativa, widely recognized for its therapeutic potential. While cannabis has been utilized medicinal purposes since ancient times, psychoactive and addictive properties led to prohibition in 1937, with only medical use being reauthorized 1998. Unlike tetrahydrocannabinol (THC), CBD lacks properties, yet name that suggests association significantly contributed public visibility. exhibits diverse pharmacological most notably anti-inflammatory effects. Additionally, it interacts key drug-metabolizing enzyme families, including cytochrome P450 (CYP) uridine 5′-diphospho-glucuronosyltransferase (UGT), which mediate phase I II metabolism, respectively. By binding these enzymes, can inhibit metabolism co-administered drugs, potentially enhance their toxicity or Mild moderate adverse events associated have reported. Advances chemical formulation techniques recently enabled strategies minimize This review provides an overview CBD, covering historical background, recent clinical trials, event profiles, interactions molecular targets such as receptors, channels, enzymes. We particularly emphasize mechanisms underlying effects interaction drugs relevant organ transplantation. Finally, we explore progress order bioavailability, will enable decreasing dose increase safety efficacy.

Language: Английский

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Investigation in the CB1 and CB2 receptor binding profile and intrinsic activity of (-) and (+)-enantiomers of some naturally occurring phytocannabinoids or synthetic derivatives

European Journal of Medicinal Chemistry Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100262 - 100262

Published: April 1, 2025

Language: Английский

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Polyphenol-rich Sorghum bicolor supplement exhibits anti-nociceptive activity and protective effects against pathological changes associated with complete Freund's adjuvant induced arthritis in rodents

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 12, P. 100481 - 100481

Published: July 8, 2024

Arthritis is a common inflammatory joint disease; causing severe pain, anxiety, and depression. Sorghum bicolor L. Moench (Pocaeae) used for treating cough, asthma, arthritic pain in Traditional Chinese Medicine (TCM). This study evaluates the anti-nociceptive anti-arthritic effects of polyphenol-rich supplement (SBS) rodents. The activity SBS was assessed using hot plate, acetic acid mouse writhing, formalin-induced paw licking tests mice. In arthritis study, rats received (50, 100, 200 mg/kg p.o) 28 days. Thirty minutes after treatment on days, 1 20, intra-articular injection Complete Freund's adjuvant (CFA) induction. Arthritic scores edema were determined before assessing motor function, depression, hyperalgesia allodynia day 28. Lipid profiles determined, ankle brain tissues analyzed oxidative stress biomarkers, alongside histopathological studies. reduced nociceptive responses induced by noxious heat, formalin CFA-injected rats, decreased volume scores, increased thresholds to thermal, cold, mechanical stimuli. activity, anxiety improved serum lipid rats. It further modulated stress, pro-inflammatory cytokines, nuclear factor kappa (NF-kB), apoptotic markers, erythroid 2-related 2 (NRF2), glutamic decarboxylase (GAD) brain-derived neurotrophic (BDNF) CFA-treated produced improvements revealed that exhibited mice reduces inflammation, hyperalgesia, depression CFA-arthritic ability modulate key biomarkers such as NF-κB, caspases, Nrf2, BDNF, GAD highlights its multifaceted approach addressing both physical psychological aspects arthritis, providing comprehensive therapeutic strategy, justifying use TCM this debilitating condition.

Language: Английский

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Bioactive Three-Dimensional Chitosan-Based Scaffolds Modified with Poly(dopamine)/CBD@Pt/Au/PVP Nanoparticles as Potential NGCs Applicable in Nervous Tissue Regeneration—Preparation and Characterization

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5376 - 5376

Published: Nov. 14, 2024

Tissue engineering of nervous tissue is a promising direction in the treatment neurological diseases such as spinal cord injuries or neuropathies. Thanks to technological progress and scientific achievements; use cells; artificial scaffolds; growth factors are becoming increasingly common. Despite challenges complex structure this tissue, regenerative medicine appears future approach improve quality life patients with injuries. Until now; most functional biomaterials used for purpose were based on decellularized extra cellular matrix (ECM) nanofibrous materials, whereas current clinically verified ones cases do not exhibit bioactivity possibility external stimulation. The aim research was develop new type bioactive, chitosan-based 3D materials applicable nerve guide conduits (NGCs) modified poly(dopamine), Au/Pt coated PVP nanoparticles, cannabidiol. NGCs prepared under microwave-assisted conditions their chemical studied using FT-IR method. Next, study will discuss novel morphology swelling abilities well susceptibility biodegradation presence collagenase lysozyme. Finally, potential field has been via cytotoxicity 1321N1 human astrocytoma cell line, which confirmed biocompatibility direct contact studies.

Language: Английский

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Comparative assessment of Omega-3 and CoQ10 as adjuncts to periodontal therapy and total antioxidant capacity of saliva in patients with chronic periodontitis: A double-blind, randomized clinical trial

The Saudi Dental Journal, Journal Year: 2024, Volume and Issue: 36(12), P. 1509 - 1514

Published: Sept. 13, 2024

Language: Английский

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