Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 975 - 975
Published: July 23, 2024
Oxidative stress, driven by reactive oxygen, nitrogen, and sulphur species (ROS, RNS, RSS), poses a significant threat to cellular integrity human health. Generated during mitochondrial respiration, inflammation, UV exposure pollution, these damage cells contribute pathologies like cardiovascular issues, neurodegeneration, cancer, metabolic syndromes. Lifestyle factors exert substantial influence on oxidative stress levels, with mitochondria emerging as pivotal players in ROS generation equilibrium. Phytochemicals, abundant plants, such carotenoids, ascorbic acid, tocopherols polyphenols, offer diverse antioxidant mechanisms. They scavenge free radicals, chelate metal ions, modulate signalling pathways mitigate damage. Furthermore, plants thriving high-altitude regions are adapted extreme conditions, synthesize secondary metabolites, flavonoids phenolic compounds bulk quantities, which act form robust defence against including radiation temperature fluctuations. These promising sources for drug development, offering innovative strategies manage stress-related ailments enhance Understanding harnessing the potential of phytochemicals from represent crucial steps combating stress-induced disorders promoting overall wellbeing. This study offers comprehensive summary production physio-pathological aspects lifestyle-induced explores antioxidants. Additionally, it presents an appraisal medicinal antioxidants, highlighting their development creation therapeutic approaches.
Language: Английский
Citations
12
South African Journal of Botany, Journal Year: 2025, Volume and Issue: 179, P. 31 - 38
Published: Feb. 8, 2025
Language: Английский
Citations
1
Clinical Hemorheology and Microcirculation, Journal Year: 2024, Volume and Issue: 87(3), P. 347 - 366
Published: Jan. 30, 2024
Ferroptosis is a form of programmed cell death that plays significant role in causing several diseases such as heart attack and failure, through alterations fat, amino acid, iron metabolism. Comprehending the regulatory mechanisms ferroptosis signaling critical because it has considerable effect on elderly’s mortality. Conversely, age-related changes substrate metabolism metabolite levels are recognized to give rise obesity. Furthermore, research proposed aging obesity-related may aggravate ferroptosis. The suppression holds potential successful therapeutic approach for managing different diseases, including sarcopenia, cardiovascular central nervous system diseases. However, pathologic biological behind function not fully comprehended yet. Physical activity could affect lipid, modulate aim this study showcase current understanding molecular leading discuss physical phenomenon.
Language: Английский
Citations
5
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 437 - 437
Published: March 28, 2025
The genus Allium contains more than 300 species where garlic, onion and leek can be found. Recent studies highlight the potential of phytochemicals present in as therapeutic agents, such antimicrobial, antihypertensive, antioxidant antiinflammatory, which makes it a widely studied an attractive option for both pharmaceutical food industries. This review aims to explore current knowledge this field. It highlights key findings regarding pharmacological approach on thiosulfinates polysulfides sativum, ampeloprasum sphaerocephalon species. Further, by integrating what has been reported previous research, proposes action mechanism formation polysulfides, will help harness nature-inspired solutions combating illness.
Language: Английский
Citations
0
Materials Science and Engineering B, Journal Year: 2025, Volume and Issue: 320, P. 118398 - 118398
Published: May 9, 2025
Language: Английский
Citations
0
Journal of Traditional and Complementary Medicine, Journal Year: 2024, Volume and Issue: 14(6), P. 644 - 655
Published: April 11, 2024
Allium sativum L. has been used medicinally and traditionally since antiquity. This study sought to examine the ethanolic extract (ASEE) in inducing apoptosis human triple-negative breast cancer (TNBC) MDA-MB-231 cells molecular interactions of identified components with cell death markers using silico method. Cytotoxicity ASEE was tested on MCF-7, MDA-MB-231, Normal Vero cells. The ROS production, apoptosis, MMP, cycle were conducted utilizing flow cytometer, western blot also performed for protein expression analysis. phytochemically characterized by HPLC while AutoDock Vina iGEMDOCK tools investigated in-silico binding interactions. method two active organosulfur chemicals, allicin alliin, ASEE. MTT test revealed significant (p < 0.05) inhibition proliferation. inhibitory effect more pronounced than MCF-7 cells, however, no substantial cytotoxicity seen normal TNBC treated high concentrations found late apoptotic stage exhibited an increase level a reduction MMP. exposure increased percentage G2/M phase. upregulated p53 Bax proteins downregulated Bcl-2, p-Akt, p-p38 proteins. Allicin alliin compounds had strong affinity targeted cancer, both showed good pharmacokinetics druglikeness properties. could be useful treatment without any safety risks.
Language: Английский
Citations
3
Food Research International, Journal Year: 2024, Volume and Issue: 188, P. 114496 - 114496
Published: May 11, 2024
Language: Английский
Citations
3
Published: May 14, 2024
Citations
0
Published: May 14, 2024
Citations
0
Published: May 14, 2024
Citations
0