An injectable CS-hydrogel incorporating TPGS for cartilage repair DOI Creative Commons
Qingqiang Tu, Dong Jiang,

Rongcheng Hu

et al.

Materials & Design, Journal Year: 2024, Volume and Issue: 241, P. 112894 - 112894

Published: March 31, 2024

Osteoarthritis (OA) is a progressive and degenerative disease associated with articular cartilage injury. Current conservative or surgical treatments cannot effectively terminate the progress of OA, usually leading to total joint replacement at end stage. Also, it still challenging treat defect for demands dual-pronged approach which simultaneously addresses both repair relief osteochondral inflammation. In this study, we embarked on pioneering exploration D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS), an FDA-approved, water-soluble derivative natural vitamin E. TPGS was found relieve inflammation in vitro vivo. We further extended application by establishing injectable collagen-chondroitin sulfate (CS) hydrogel incorporated (TPGS@CS-hydrogel), achieved excellent repair. RNA-seq showed that anti-inflammatory effect TPGS@CS-hydrogel were related interruption interplay oxidative stress inflammation, thus promoting regeneration. conclusion, provided new insights prevention treatment lesion.

Language: Английский

Anthocyanins and Anthocyanidins in the Management of Osteoarthritis: A Scoping Review of Current Evidence DOI Creative Commons

X. B. Ma,

Kok‐Yong Chin,

Sophia Ogechi Ekeuku

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 301 - 301

Published: Feb. 21, 2025

Background/Objectives: The consumption of food rich in anthocyanins, a natural pigment found plants, has been associated with improved joint health. However, systematic efforts to summarise the effects anthocyanins and their deglycosylated forms, anthocyanidins, managing osteoarthritis (OA) are lacking. This scoping review aims comprehensively current evidence regarding role anthocyanidins OA management highlights potential research areas. Methods: A comprehensive literature search was performed using PubMed, Scopus, Web Science January 2025 look for primary studies published English, main objective investigating chondroprotective regardless study designs. Results: seven included showed that suppressed activation inflammatory signalling, upregulated sirtuin-6 (cyanidin only), autophagy (delphinidin only) chondrocytes challenged various stimuli (interleukin-1β, oxidative stress, or advanced glycation products). Anthocyanins also preserved cartilage integrity increased pain threshold animal models OA. No clinical trial this field, suggesting translation gap. Conclusions: In conclusion, agents, but more investigations required overcome gap translation.

Language: Английский

Citations

0
Palm Tocotrienol Preserves Trabecular Osteocyte Indices and Modulates the Expression of Osteocyte Markers in Ovariectomized Rats DOI Creative Commons

Sophia Ogechi Ekeuku,

Shafiq Zikry Zarir,

A Razali

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1220 - 1220

Published: May 18, 2025

Background/Objective: Palm tocotrienol has bone-protective properties in animal models, yet its underlying mechanism remains unclear. Given osteocytes’ role bone homeostasis, this research aimed to investigate the effects of palm on quantity osteocytes and expression osteocyte-specific markers ovariectomized rats. Methods: Adult female rats (Sprague Dawley; three-month-old; n = 6/group) were randomly divided into baseline, sham control, unemulsified (UPT), emulsified (EPT), positive control. The baseline group was euthanized without intervention, whereas underwent a laparotomy procedure which ovaries not excised. other groups bilateral removal subsequently received UPT (100 mg/kg/day, 50% vitamin E), EPT 25% or combination glucosamine sulfate (250 mg/kg/day) calcium carbonate (1% drinking water). Control induced with similar gavage stress olive oil. After 10 weeks, all sacrificed for serum analysis. Results: significantly increased trabecular osteocyte total lacunae numbers (p < 0.05 versus control). Both treatments reduced mRNA levels dentin matrix protein-1 control), sclerostin unchanged > However, neither nor improved circulating skeletal redox status Conclusions: may support health by preserving modulating osteocyte-mediated remodeling. Further is required elucidate precise mechanisms.

Language: Английский

Citations

0
Updates in the skeletal and joint protective effects of tocotrienol: a mini review DOI Creative Commons

Kok-Yong Chin

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: June 21, 2024

Osteoporosis and osteoarthritis continue to pose significant challenges the aging population, with limited preventive options pharmacological treatments often accompanied by side effects. Amidst ongoing efforts discover new therapeutic agents, tocotrienols (TTs) have emerged as potential candidates. Derived from annatto bean palm oil, TTs demonstrated efficacy in improving skeletal joint health numerous animal models of bone loss osteoarthritis. Mechanistic studies suggest that exert their effects through antioxidant, anti-inflammatory, Wnt-suppressive, mevalonate-modulating mechanisms bone, well self-repair chondrocytes. However, human clinical trials this field remain scarce. In conclusion, hold promise agents for preventing osteoporosis osteoarthritis, pending further evidence trials.

Language: Английский

Citations

2
An injectable CS-hydrogel incorporating TPGS for cartilage repair DOI Creative Commons
Qingqiang Tu, Dong Jiang,

Rongcheng Hu

et al.

Materials & Design, Journal Year: 2024, Volume and Issue: 241, P. 112894 - 112894

Published: March 31, 2024

Osteoarthritis (OA) is a progressive and degenerative disease associated with articular cartilage injury. Current conservative or surgical treatments cannot effectively terminate the progress of OA, usually leading to total joint replacement at end stage. Also, it still challenging treat defect for demands dual-pronged approach which simultaneously addresses both repair relief osteochondral inflammation. In this study, we embarked on pioneering exploration D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS), an FDA-approved, water-soluble derivative natural vitamin E. TPGS was found relieve inflammation in vitro vivo. We further extended application by establishing injectable collagen-chondroitin sulfate (CS) hydrogel incorporated (TPGS@CS-hydrogel), achieved excellent repair. RNA-seq showed that anti-inflammatory effect TPGS@CS-hydrogel were related interruption interplay oxidative stress inflammation, thus promoting regeneration. conclusion, provided new insights prevention treatment lesion.

Language: Английский

Citations

0