Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155745 - 155745
Published: Nov. 29, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 14, 2025
Metabolic reprogramming is one of the major biological features malignant tumors, playing a crucial role in initiation and progression cancer. The tumor microenvironment consists various non-cancer cells, such as hepatic stellate cancer-associated fibroblasts (CAFs), immune well extracellular matrix soluble substances. In liver cancer, metabolic not only affects its own growth survival but also interacts with other cells by influencing expression release metabolites cytokines (such lactate, PGE2, arginine). This interaction leads to acidification restricts uptake nutrients resulting competition symbiosis. At same time, neighboring during proliferation differentiation processes impacts immunity. article provides comprehensive overview crosstalk between cancer their microenvironment, deepening our understanding relevant findings pathways. contributes further regulation development evasion mechanisms while providing assistance advancing personalized therapies targeting pathways for anti-cancer treatment.
Language: Английский
Citations
1
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 2, 2025
Glutaminase (GLS), a crucial gene regulating glutaminolysis, has received much attention as it was found to regulate tumor metabolism and copper-induced cell death. However, its biological roles mechanisms in human cancers remain obscure. Consequently, the integrated pan-cancer analyses experiments were conducted elucidate oncological functions. We GLS differentially expressed upregulated predicted poor survival, clinicopathological progression, heterogeneity. Single-cell analysis closely related various functions pathways. Spatial transcriptomic expression mainly derived from cells, which implies cells may have stronger ability utilize glutamine than antitumor immune microenvironment (TME). Meanwhile, we noticed strongly infiltration of stromal immunomodulatory genes, activity some conventional agents, therapeutic response immunotherapy. Moreover, enrichment suggested metabolic reprogramming, innate adaptive immunity suppression, extracellular matrix remodeling. Finally, observed highly our gastric cancer (GC) cohort. As an independent risk factor for GC prognosis, high-GLS pathological progression. Inhibiting effectively prevented proliferation, migration, invasion triggered apoptosis. In conclusion, is underlying biomarker TME, drug sensitivity, immunotherapy response. Targeting can facilitate implementation individualized combined treatment strategies.
Language: Английский
Citations
0
Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 12, 2025
Language: Английский
Citations
0
Translational Cancer Research, Journal Year: 2025, Volume and Issue: 14(1), P. 296 - 312
Published: Jan. 1, 2025
The occurrence rate of liver cancer is increasing in recent years. significance lactylation tumor cells should not be neglected. This study aimed to discover a gene signature related that can used for diagnostic applications. Data were downloaded from Cancer Genome Atlas (TCGA), GSE14520, GSE84402, and GSE62232 datasets. Differential analysis random forest performed hepatocellular carcinoma (HCC). Receiver operating characteristic (ROC) curve was evaluate efficiency, logistic regression established obtain the risk score equation. Besides, expression genes identified by TCGA database verified real-time quantitative polymerase chain reaction (RT-PCR). In order analyze prognostic performance, patients diagnosed with HCC stratified into either high or low categories based on median score. addition, immunotherapy drug sensitivity groups assessed. performance model validated Gene Expression Omnibus (GEO) dataset. had worse outcomes than those database. ROC curves showed characteristics lactylation-related good predictive capability. Furthermore, we developed nomogram patients, utilizing data resources TCGA. Finally, terms assessing potency group lower Tumor Immune Dysfunction Exclusion (TIDE) score, indicating response immunotherapy. Our identification associated presents promising avenue development targeted immunotherapeutic strategies.
Language: Английский
Citations
0
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217714 - 217714
Published: April 1, 2025
Language: Английский
Citations
0
Trends in Endocrinology and Metabolism, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Lipid Research, Journal Year: 2024, Volume and Issue: 65(11), P. 100660 - 100660
Published: Sept. 26, 2024
Hepatocellular carcinoma (HCC) poses significant treatment challenges due to high postoperative recurrence rates and the limited effectiveness of targeted medications. Researchers have identified unique metabolic profiles cancer stem cells (CSCs) as primary drivers recurrence, metastasis, drug resistance. Therefore, address therapeutic conundrum, this study focused on rewinding reprogramming CSCs a novel strategy. HCC exhibited elevated fatty acid (FA) metabolism compared with parental cells. To specifically target FA in CSCs, we utilized cerulenin, synthase (FASN) inhibitor. Surprisingly, cerulenin can diminish CSC-like characteristics, including stemness gene expression, spherogenicity, tumorigenicity, metastatic potential. In addition, sorafenib, multikinase inhibitor used therapy for advanced HCC, was employed combination demonstrating great synergistic effect, particularly CSCs. Importantly, our RNA sequencing analysis disclosed that amyloid protein precursor (APP) is crucial downstream effector FASN regulating CSC properties. We found APP plays role CSCs' characteristics be inhibited by cerulenin. By focusing metabolism, FASN/APP axis viable develop more potent strategy HCC.
Language: Английский
Citations
3
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217472 - 217472
Published: Jan. 1, 2025
Language: Английский
Citations
0
Molecular Oncology, Journal Year: 2024, Volume and Issue: unknown
Published: June 4, 2024
Rewiring of cellular metabolism is now fully recognized as a hallmark cancer. Tumor cells reprogram metabolic pathways to meet the energetic and macromolecular demands support unrestricted growth survival under unfavorable conditions. It becoming apparent that these adaptations underpin most traits define cancer cell's identity, including ability avoid immune surveillance, endure nutrient oxygen restrictions, detach migrate from their natural histological niche, avert human‐made aggressions ( i.e. , therapy). In recent study, Benichou collaborators identify carbohydrate‐responsive element‐binding protein (ChREBP), master regulator physiological glucose metabolism, an oncogene in hepatocellular carcinoma (HCC) development. Upregulation ChREBP expression results self‐stimulatory loop interconnecting PI3K/AKT signaling feed fatty acid nucleotide synthesis supporting tumorigenesis. Importantly, pharmacological inhibition activity quells vivo HCC tumor without causing systemic toxicity. This study identifies novel oncometabolic open up new avenues improve treatment deadly tumor.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 17, 2024
Despite the advanced technologies and global attention on cancer treatment strategies, continues to claim lives adversely affects socio-economic development. Although combination therapies were anticipated eradicate this disease, resilient restorative nature of cancers allows them proliferate at expense host immune cells energetically. This proliferation is driven by metabolic profiles specific type patient. An emerging field exploring reprogramming (MR) predict effective treatments. mini-review discusses recent advancements in MR that have contributed predictive, preventive, precision medicine. Current perspectives mechanisms various types prospects for personalized medicine are essential optimizing outputs necessary
Language: Английский
Citations
0