Nutraceutical-based telomerase inhibitors: Renewed hope for cancer therapy

Phytomedicine Plus, Journal Year: 2024, Volume and Issue: 4(2), P. 100537 - 100537

Published: Feb. 20, 2024

: Attributes of potential targets for anticancer therapy are currently being investigated telomeres, telomerase, and their combined complex. Telomerase (TRTase) is a distinct reverse transcriptase that thought to be the leader in almost all cancer-derived cells primarily charge controlling telomere (TLM) length. This enzyme therefore guarantees unabated cell division during carcinogenesis, characteristic cancer, this distinguishing factor has made TRTase spotlight target pharmaceutical research cancer therapy. The capacity nutraceuticals inhibit TRTase, impair TLMs, hinder complex formation offers window opportunity discovery new cancer-treatment targets. review attempts provide fundamental understanding TLM investigation, regulatory frameworks, diverse binding proteins TLM-TRTase structure. Moreover, study highlights address inhibition at molecular level, inhibitors catalytic subunits. thorough knowledge TRTase's physiological action will offer crucial information boosting effectiveness plausible chemotherapeutic drug designs.

Language: Английский

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Global research progress and trends in traditional Chinese medicine for chronic kidney disease since the 21st century: a bibliometric analysis

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 17, 2025

This study analyzed literature on traditional Chinese medicine (TCM) in treating chronic kidney disease (CKD) to identify research trends and provide guidance for future studies clinical practice. The used data from Web of Science 2000 2024 analyze English-language CKD TCM. Bibliometric analysis was done using R software the bibliometric package, with scientific mapping visualization conducted tools like Citespace, VOSviewer, ScimagoGraphica explore connections. revealed that a total 1,153 relevant documents were retrieved, number published articles showed an increasing trend, reaching peak 2022. In terms article publication, China ranked first 760 articles, closely followed by United States 132 articles. Guangzhou University Traditional Medicine 60 papers, most among academic institutions, Shanghai 54 papers. individual authors, Liu Xinhui holds record highest totaling 17, Li Ping Shunmin. prevalent keywords include "chronic disease," "TCM," "oxidative stress." Currently, prominent areas interest network pharmacology, gut microbiota, oxidative stress, related topics. current trend this field is towards adoption novel methodologies such as pharmacology emphasis exploring relationship between microbiota CKD. Global TCM treatment showing positive development but further safety, efficacy evaluation, international cooperation still needed. adopt new methods focus mechanism

Language: Английский

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Therapeutic Effects of Quercetin on Renal Fibrosis and Injury

Integrative Medicine in Nephrology and Andrology, Journal Year: 2025, Volume and Issue: 12(1)

Published: Jan. 30, 2025

Quercetin is a natural flavonoid found in variety of herbs and the main active ingredient several herbal formulas for treating kidney disease. Numerous studies have shown that quercetin can effectively attenuate acute injury (AKI) by inhibiting renal inflammation, ferroptosis, cell apoptosis. ameliorates fibrosis chronic disease (CKD) attenuating epithelial-to-mesenchymal transition, cellular senescence, other mechanisms. Therefore, may be potential drug treatment diseases. In this review, recent advances therapeutic effects on mechanisms AKI CKD are discussed.

Language: Английский

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Manshenkang granules alleviate fibrosis in chronic renal failure rats by regulating the PDE4b/cAMP pathway

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119506 - 119506

Published: Feb. 1, 2025

Language: Английский

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Unveiling the therapeutic potential of berberine: its therapeutic role and molecular mechanisms in kidney diseases

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 21, 2025

Berberine (BBR) is a pentacyclic benzylisoquinoline alkaloid widely distributed across various medicinal plants. Recent studies have demonstrated that berberine possesses broad spectrum of pharmacological activities, including not only antioxidant properties but also the ability to lower blood glucose, modulate lipid profiles, and mitigate inflammation. These findings suggest holds significant potential as therapeutic agent for renal diseases, highlighting its substantial research value. Moreover, when administered orally, has been shown exhibit wide safety margin. Several identified berberine's renoprotective effects range kidney disorders, diabetic nephropathy, fibrosis, aging, toxicity induced by chemotherapy antibiotics. underscore evolving both acute injury (AKI) chronic disease (CKD). In summary, discussed in this article provides comprehensive overview BBR elucidates molecular mechanisms underlying treatment disease. Furthermore, underscores significance promising disorders.

Language: Английский

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Astragaloside IV- loaded biomimetic nanoparticles target IκBα to regulate neutrophil extracellular trap formation for sepsis therapy

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 28, 2025

This study explored the novel mechanism of Astragaloside IV (As) in treating sepsis and its application through a biomimetic nano-delivery system (As@ZM). Sepsis, condition organ dysfunction caused by an abnormal host response to infection, poses significant threat global health due high mortality rate. Our findings revealed new for As sepsis, which involved reduction neutrophil extracellular traps (NETs) release, potentially related binding with IκBα inhibit activation NF-κB pathway. treated neutrophils also improved immune microenvironment crosstalk endothelial cells lung epithelial cells. However, stability bioavailability limited clinical application. To address this issue, we had developed ZIF-8-based that achieved targeted delivery membrane coating, significantly enhancing therapeutic efficacy As. The innovative design As@ZM offered strategy treatment, potential improve outcomes.

Language: Английский

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IL-1β and associated molecules as prognostic biomarkers linked with immune cell infiltration in colorectal cancer: an integrated statistical and machine learning approach

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 28, 2025

Abstract Purpose Colorectal cancer (CRC) is the third most common globally, necessitating novel biomarkers for early diagnosis and treatment. This study proposes an efficient pipeline leveraging integrated bioinformatics machine learning framework to enhance identification of diagnostic prognostic CRC. Methods A selection methylated differentially expressed genes (MeDEGs) features (genes) was made using both statistical Machine (ML) approaches from publically available datasets. These were subjected STRING network construction hub estimation, separately. Also, essential miRNAs (micro-RNAs) TFs (Transcription factors) as regulatory elements revealed findings validated through scRNA-seq analysis, promoter methylation, gene expression levels correlated with pathological stage, interaction tumor-infiltrating immune cells. Results Through analysis pipeline, we identified 27 genes, among which CTNNB1, GSK3B, IL-1β, MYC, PXDN, TP53, EGFR, SRC, COL1A1, TGBF1 showed better behaviour. approach includes development K-Nearest Neighbors (KNN), Artificial Neural Networks (ANN), Random Forest (RF) models TCGA datasets, achieving accuracy range between 99 100%. The Area Under Curve (AUC) value each model 1.00, signifying good classification performance. high some associated poor prognosis, concluding IL-1β a biomarker. Additionally, NF-κB microRNAs (miR-548d-3p, miR-548-ac) (NFκB STAT5A) play major role in comprehensive Furthermore, such TGFB1, COL1A1 significantly infiltrates, suggesting their potential CRC progression. Conclusion Overall, elevated coupled abnormal DNA its consequent effect on PI3K/Akt signaling pathway are relevant therapeutic marker Additional molecular candidates reveal insights into epigenetic targets association cell infiltration.

Language: Английский

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Necrosis-like cell death modes in heart failure: the influence of aetiology and the effects of RIP3 inhibition

Basic Research in Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Abstract Since cell dying in heart failure (HF) may vary based on the aetiology, we examined main forms of regulated necrosis, such as necroptosis and pyroptosis, hearts damaged due to myocardial infarction (MI) or pressure overload. We also investigated effects a drug inhibiting RIP3, proposed convergent point for both these necrosis-like death modes. In rat hearts, left ventricular function, remodelling, pro-cell death, pro-inflammatory events were investigated, pharmacodynamic action RIP3 inhibitor (GSK'872) was assessed. Regardless HF cells necroptosis, albeit upstream signals be different. Pyroptosis observed only post-MI HF. The dysregulated miRNAs accompanied by higher levels predicted target, HMGB1, its receptors (TLRs), well exacerbation inflammation likely originating from macrophages. suppressed unlike normalised tended decrease collagen content affect macrophage infiltration without affecting cardiac function structure. mitigated local circulating HMGB1 rats with Elevated serum detected patients positively correlated C-reactive protein, highlighting axis. conclusion, MI-, but not overload-induced HF, pyroptosis operate might underlie pathogenesis. RIP3-targeting pharmacological intervention protect preventing pro-death mechanisms, however, additional strategies targeting multiple pathways exhibit greater cardioprotection.

Language: Английский

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Natural products in traditional Chinese medicine for renal fibrosis: a comprehensive review

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Renal fibrosis represents the terminal pathological manifestation of most chronic kidney diseases, driving progressive loss renal function. Natural products have emerged as promising therapeutic agents for preventing and ameliorating due to their multi-target efficacy favorable safety profiles. In this review, we conducted a comprehensive literature search on PubMed using keywords “natural product” “renal fibrosis” from 2004 2025, identifying 704 relevant articles. We systematically categorize discuss biological effects key natural formulations with antifibrotic potential, focusing five major classes: glycosides, flavonoids, phenolic compounds, anthraquinones, terpenoids. Representative compounds each category are highlighted mechanisms action, including modulation oxidative stress, inflammation, autophagy, signaling pathways. This review aims provide theoretical foundation development product-based therapies combat fibrosis, offering insights into potential future research directions.

Language: Английский

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Chemical nature of metabolic activation of natural products in traditional Chinese medicines possibly associated with toxicities

Acupuncture and Herbal Medicine, Journal Year: 2024, Volume and Issue: 4(2), P. 184 - 196

Published: May 29, 2024

Ensuring the safety of traditional Chinese medicines (TCM) has perennially presented a universal challenge in healthcare realm. Meticulous investigations into toxicological intricacies natural products are paramount significance, particularly regarding metabolic transformation these substances and subsequent generation reactive intermediates. This biochemical process underlies genesis diverse toxic manifestations, including hepatotoxicity, nephrotoxicity, pulmonary toxicity, genotoxicity. Compounds sorted within TCM, pyrrolizidine alkaloids, anthraquinones, furanoterpenoids, alkenylbenzenes, bisbenzylisoquinoline flavonoids, methylenedioxyphenyl derivatives, evince spectrum deleterious mechanisms upon activation. review provides comprehensive delineation pathways through which compounds induce toxicity via emphasizes chemical involved activation that may trigger cascade, rather than superficial phenomenon. Furthermore, this study enriches extant literature by delving advancements elucidating engendered In conclusion, highlights importance scrutinizing insights judicious safe use TCM.

Language: Английский

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