Antioxidants,
Journal Year:
2024,
Volume and Issue:
14(1), P. 17 - 17
Published: Dec. 26, 2024
Spinal
cord
injury
(SCI)
initiates
a
cascade
of
secondary
damage
driven
by
oxidative
stress,
characterized
the
excessive
production
reactive
oxygen
species
and
other
molecules,
which
exacerbate
cellular
tissue
through
activation
deleterious
signaling
pathways.
This
review
provides
comprehensive
critical
evaluation
recent
advancements
in
antioxidant-based
therapeutic
strategies
for
SCI,
including
natural
compounds,
RNA-based
therapies,
stem
cell
interventions,
biomaterial
applications.
It
emphasizes
limitations
single-regimen
approaches,
particularly
their
limited
efficacy
suboptimal
delivery
to
injured
spinal
tissue,
while
highlighting
synergistic
potential
combination
therapies
that
integrate
multiple
modalities
address
multifaceted
pathophysiology
SCI.
By
analyzing
emerging
trends
current
limitations,
this
identifies
key
challenges
proposes
future
directions,
refinement
antioxidant
systems,
development
multi-targeted
overcome
structural
complexities
cord.
work
underscores
pressing
need
innovative
integrative
approaches
advance
clinical
translation
interventions
improve
outcomes
SCI
patients.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2406 - 2406
Published: Feb. 18, 2024
Spinal
cord
injury
(SCI)
leads
to
devastating
sequelae,
demanding
effective
treatments.
Recent
advancements
have
unveiled
the
role
of
neutrophil
extracellular
traps
(NETs)
produced
by
infiltrated
neutrophils
in
exacerbating
secondary
inflammation
after
SCI,
making
it
a
potential
target
for
treatment
intervention.
Previous
research
has
established
that
intravenous
administration
stem
cell-derived
exosomes
can
mitigate
injuries.
While
demonstrated
ability
modulate
microglial
reactions
and
enhance
blood-brain
barrier
integrity,
their
impact
on
deactivation,
especially
context
NETs,
remains
poorly
understood.
This
study
aims
investigate
effects
MSC-derived
exosomes,
with
specific
focus
NET
formation,
elucidate
associated
molecular
mechanisms.
Exosomes
were
isolated
from
cell
supernatants
amnion-derived
mesenchymal
cells
using
ultracentrifugation
method.
injuries
induced
Sprague-Dawley
rats
(9
weeks
old)
clip
model,
100
μg
1
mL
PBS
or
alone
intravenously
administered
24
h
post-injury.
Motor
function
was
assessed
serially
up
28
days
following
injury.
On
Day
3
28,
spinal
specimens
analyzed
evaluate
extent
formation
NETs.
Flow
cytometry
employed
examine
circulating
Exogenous
miRNA
electroporated
into
effect
inflammatory
formation.
Finally,
biodistribution
64Cu-labeled
animal
positron
emission
tomography
(PET).
Rats
treated
exhibited
substantial
improvement
motor
recovery
reduction
size.
Notably,
there
significant
decrease
infiltration
within
cord,
as
well
forming
NETs
circulation.
In
vitro
investigations
indicated
accumulated
vicinity
nuclei
activated
neutrophils,
miR-125a-3p
mimic
significantly
diminished
while
inhibitor
reversed
effect.
PET
studies
revealed
that,
although
majority
transplanted
sequestered
liver
spleen,
notably
high
quantity
detected
damaged
when
compared
normal
rats.
play
pivotal
alleviating
injury,
part
through
deactivation
via
miR-125a-3p.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 723 - 723
Published: Jan. 16, 2025
Mesenchymal
stem
cell-derived
extracellular
vesicles
(MSC-EVs)
have
emerged
as
a
promising
therapeutic
strategy
for
spinal
cord
injury
(SCI).
These
nanosized
possess
unique
properties
such
low
immunogenicity
and
the
ability
to
cross
biological
barriers,
making
them
ideal
carriers
delivering
bioactive
molecules
injured
tissues.
MSC-EVs
been
demonstrated
exert
multiple
beneficial
effects
in
SCI,
including
reducing
inflammation,
promoting
neuroprotection,
enhancing
axonal
regeneration.
Recent
studies
delved
into
molecular
mechanisms
underlying
MSC-EV-mediated
effects.
Exosomal
microRNAs
(miRNAs)
identified
key
regulators
of
various
cellular
processes
involved
SCI
pathogenesis
repair.
miRNAs
can
influence
oxidative
stress,
apoptosis
by
modulating
gene
expression.
This
review
summarized
current
state
MSC-EV-based
therapies
highlighting
potential
clinical
applications.
We
discussed
challenges
limitations
translating
these
practice,
inconsistent
EV
production,
complex
cargo
composition,
need
targeted
delivery
strategies.
Future
research
should
focus
on
optimizing
production
characterization,
identifying
miRNAs,
developing
innovative
systems
maximize
SCI.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
73(9), P. 5526 - 5536
Published: Feb. 21, 2025
Silicon
dioxide
particles
(SiO2)
have
been
widely
used
in
food
additives.
Increasing
data
demonstrate
that
SiO2
can
cause
multisystem
damage
through
oxidative
stress.
Quercetin
(Que)
is
one
of
the
most
popular
nutritional
antioxidants.
Ferroptosis
reduces
level
angiogenesis.
However,
whether
Que
alleviates
inhibition
testicular
angiogenesis
by
relieving
SiO2-induced
ferroptosis
via
ROS/PPARγ
unclear.
Based
on
this,
we
established
SiO2-exposed
mice
and
C166
cell
models
added
stress
activators
Sanguinarine
chloride
(SAN),
PPARγ
inhibitor
GW9662,
activator
Erastin
to
vitro.
The
results
showed
exposure
group
had
antioxidant
dysfunction;
was
significantly
downregulated;
levels
were
increased;
reduced.
treatment
alleviate
these
changes.
addition
SAN,
reduced
effects
activating
stress,
inhibiting
PPARγ,
ferroptosis,
respectively.
In
general,
ROS/PPARγ,
thus
restoring
mice.
International Endodontic Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 31, 2025
Abstract
Aim
Recent
findings
suggest
that
mitigating
ferroptosis
could
serve
as
an
effective
strategy
for
treating
inflammation.
This
study
aimed
to
investigate
the
role
enhancer
of
zeste
homologue
2
(
EZH2
)
mediated
signal
transducer
and
activator
transcription
3
stat3
methylation
plays
in
modulation
pulpitis.
The
results
offer
potential
advancements
therapeutic
approaches
pulpitis
provide
new
insights
strategies
managing
this
condition.
Methodology
Bioinformatics
analysis
combined
with
capture
sequencing
fl/fl
Cre
+/−
pulp
tissue
was
used
explore
association
between
ferroptosis.
In
study,
we
knockout
model
prepared
through
lentiviral
transduction
LPS‐induced
inflammatory
endometrial
mesenchymal
stromal
cells
confirm
EZH2/STAT3
axis
Results
identified
a
link
DNA
methylation.
Methylation
further
revealed
regulation
STAT3
by
EZH2.
vitro,
lipopolysaccharide
(LPS)
stimulation
induced
ferroptosis,
whereas
disruption
suppressed
expression
but
increased
Glutathione
Peroxidase
4
(GPX4)
expression,
leading
escalation
oxidative
stress
exacerbation
illustrates
complex
interactions
methylation,
oral
inflammation,
highlighting
targets.
Conclusions
Overall,
crucial
EZH2‐mediated
activates
regulating
GPX4
expression.
provides
treatment
advances
our
understanding
pathogenesis
Stem Cell Research & Therapy,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 17, 2025
Abstract
Spinal
cord
injury
(SCI)
is
a
severe
to
the
central
nervous
system
that
often
results
in
permanent
neurological
dysfunction.
Current
treatments
have
limited
efficacy
and
face
challenges
restoring
function
after
injury.
Recently,
stem
cell-derived
exosomes
gained
attention
as
an
experimental
treatment
for
SCI
due
their
unique
properties,
including
superior
biocompatibility,
minimal
immunogenicity
non-tumorigenicity.
With
potential
cell-free
therapy,
promote
repair
by
enhancing
nerve
regeneration,
reducing
inflammation
stabilizing
blood-spinal
barrier.
This
review
summarizes
advances
exosome
research
over
past
years,
focusing
on
mechanisms
future
prospects.
Despite
promising
therapeutic
potential,
clinical
translation
remains
challenging
standardization
of
isolation
protocols,
compositional
consistency
long-term
safety
profiles
require
further
investigation.
