Medicinal Herbal Extracts: Therapeutic Potential in Acute Lung Injury DOI Creative Commons
Jae‐Won Lee, Hee Jae Lee,

Seok Han Yun

et al.

Future Pharmacology, Journal Year: 2024, Volume and Issue: 4(4), P. 700 - 715

Published: Oct. 3, 2024

Acute lung injury (ALI) is induced by pneumonia, sepsis and other conditions. The disease characteristics include severe inflammation, in which various cells, such as epithelial macrophages, neutrophils, play a pivotal role. Corticosteroids antibiotics are used to treat ALI; however, they may have side effects. Cumulative data confirm that traditional herbal medicines exert therapeutic effects against endotoxin-induced inflammatory responses both vitro vivo ALI studies. This review briefly describes the anti-ALI of medicinal extracts (MHEs) their molecular mechanisms, especially focusing on Toll-like receptor 4/nuclear factor kappa B cell pathways, with brief summary experimental models. Thus, present highlights excellent potential MHEs for therapy prevention also be useful establishment

Language: Английский

Sulfur dioxide controls M1 macrophage polarization by sulphenylation of prolyl hydroxylase 2 at cysteine 260 DOI Creative Commons
Han Zhang,

Boyang Lv,

Keyu Liu

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Pathological Interplay of NF-κB and M1 Macrophages in Chronic Inflammatory Lung Diseases DOI
Fadiyah Jadid Alanazi,

Abeer Nuwayfi Alruwaili,

Nouf Afit Aldhafeeri

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 269, P. 155903 - 155903

Published: March 7, 2025

Language: Английский

Citations

2
Macrophage polarization and its impact on idiopathic pulmonary fibrosis DOI Creative Commons

Zhouling Ge,

Yong Q. Chen,

Leikai Ma

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 26, 2024

Idiopathic pulmonary fibrosis (IPF) is a lung disease that worsens over time, causing in the lungs and ultimately resulting respiratory failure high risk of death. Macrophages play crucial role immune system, showing flexibility by transforming into either pro-inflammatory (M1) or anti-inflammatory (M2) macrophages when exposed to different stimuli, impacting development IPF. Recent research has indicated polarization onset progression M1 secrete inflammatory cytokines agents early damage fibrosis, while M2 support tissue healing releasing cytokines. Developing novel treatments for IPF relies on thorough comprehension processes involved macrophage The review outlines regulation its impact IPF, with goal investigating possible therapeutic benefits advancement

Language: Английский

Citations

15
The role of natural products targeting macrophage polarization in sepsis-induced lung injury DOI Creative Commons

Yake Li,

Sinan Ai,

Yuan Li

et al.

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 5, 2025

Language: Английский

Citations

1
VASP Knockdown Ameliorates Lipopolysaccharide-Induced Acute Lung Injury with Inhibition of M1 Macrophage Polarization Through the cGMP-PKG Signaling Pathway DOI Creative Commons
Jiajia Tang,

Yiwei Ding,

Wei Chen

et al.

Inflammation, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Alveolar macrophage (AM) polarization plays a pivotal role in the inflammatory response during acute lung injury (ALI). As reported previously, vasodilator-stimulated phosphoprotein (VASP) may function as an anti-inflammatory agent hepatic tissues. However, specific of VASP ALI-induced remains unclear. To elucidate ALI, we established lipopolysaccharide (LPS)-induced M1 model MH-S cells. RNA sequencing was performed to identify differentially expressed genes polarization. The results revealed significant upregulation gene. Subsequently, gene knockdown lungs achieved by intratracheal delivery VASP-AAV6, and resulting ALI symptoms were assessed. also knocked down cells; these cells then stimulated with LPS for 24 h, polarization-related markers macrophages analyzed. Finally, validate involvement PKG-VASP signaling pathway, experiments conducted PKG agonist (8-Br-cGMP) inhibitor (KT5823), effects modulating pathway on investigated. notably ameliorated mice LPS-induced ALI. Additionally, vitro showed that protected from inhibiting polarization, its protective partially mediated cGMP-PKG pathway.

Language: Английский

Citations

1
The SERPINB4 gene mutation identified in twin patients with Crohn’s disease impaires the intestinal epithelial cell functions DOI Creative Commons

Xiaomei Ouyang,

Junhui Lin,

Ying Lin

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 21, 2025

Crohn's disease (CD) is a chronic inflammatory autoimmune of unknown etiology. To identify new targets related to the initiation CD, we screened pair twins with which rare phenomenon in Chinese population, for genetic susceptibility factors. Whole-exome sequencing (WES) these patients revealed mutation their SERPINB4 gene. Therefore, studied wider clinical cohort CD or ulcerous colitis (UC), healthy individuals, and those family history this by Sanger sequencing. The single-nucleotide difference gene, was unique twin led substitution lysine glutamic acid residue. Functional analysis indicated that inhibited proliferation, colony formation, wound healing, migration intestinal epithelial cells (IECs). Furthermore, induced apoptosis activated apoptosis-related proteins IECs, caspase inhibitor significantly reduced effects. Transcriptome expression genes encoding proinflammatory (IL1B, IL6, IL17, IL24, CCL2, CXCR2) key immune response (S100A9, MMP3, MYC) upregulated during mutant-induced apoptosis. Thus, heterozygous gene causes dysfunction would disrupt barrier contribute development inflammation. activation might represent novel therapeutic target bowel disease.

Language: Английский

Citations

0
Macrophage pyroptosis and its crucial role in ALI/ARDS DOI Creative Commons

Yuju Cai,

Luorui Shang,

Fangyuan Zhou

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 14, 2025

Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS) is a severe clinical syndrome characterized by high morbidity and mortality, primarily due to injury. However, the pathogenesis of ALI/ARDS remains complex issue. In recent years, role macrophage pyroptosis in injury has garnered extensive attention worldwide. This paper reviews mechanism pyroptosis, discusses its ALI/ARDS, introduces several drugs intervening measures that can regulate influence progression ALI/ARDS. By doing so, we aim enhance understanding provide novel insights for treatment.

Language: Английский

Citations

0
Deciphering Immune Tolerance in Allogeneic Pig Pregnancy DOI Creative Commons
Josep M. Cambra, Cristina A. Martínez, Heriberto Rodríguez‐Martínez

et al.

Theriogenology, Journal Year: 2025, Volume and Issue: 238, P. 117363 - 117363

Published: Feb. 27, 2025

Language: Английский

Citations

0
Quercetin attenuates DEHP-induced pyroptosis and programmed necrosis in chicken duodenum through regulation of the TLR4/MyD88/NF-κB pathway DOI

Ruirui Xie,

Tong Xu, Yilin Yin

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: 372, P. 126016 - 126016

Published: March 6, 2025

Language: Английский

Citations

0
Paquinimod‐hydrogel hybrid microneedle array patch alleviates hypertrophic scar via inhibiting M1 polarization DOI Creative Commons
Zi‐Hui Zhang, Peng Wang,

Hengdeng Liu

et al.

Bioengineering & Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Abstract Hypertrophic scar (HS) is one of the most common complications skin injuries, with a lack effective therapeutic approaches to date. Most current research has focused on dysfunction hypertrophic fibroblasts (HSFBs) and dermal vascular endothelial cells (HDVECs), neglecting crucial role inflammatory microenvironment that causes them be abnormal. In this study, we first discovered validated S100A8/9 specific inhibitor Paquinimod could inhibit macrophage polarization toward M1, further suppress proliferation, migration, collagen formation, angiogenesis HSFBs HDVECs in vitro. This mechanism also been rat model HS. Then, developed good biocompatibility penetrability Paquinimod‐Hydrogel Hybrid Microneedle Array Patch (PHMAP) for HS treatment. With advantages excellent penetrability, surface sealing, sustained release, precise uniform distribution, PHMAP exhibited superior efficacy over intravenous intradermal injections. These results suggest can promising advanced solution prevention therapies.

Language: Английский

Citations

0