Fermented rhubarb alleviates metabolic dysfunction-associated steatotic liver disease symptoms by modulating gut microbiota and activating the hepatic insulin signaling pathway DOI

Heng Yuan,

Junyu Zhou, Ting Zhang

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105720 - 105720

Published: Dec. 1, 2024

Language: Английский

A critical review of microbiome-derived metabolic functions and translational research in liver diseases DOI Creative Commons
Raja Ganesan,

Durairaj Thirumurugan,

Saranya Vinayagam

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 24, 2025

Significant changes in gut microbial composition are associated with chronic liver disease. Using preclinical models, it has been demonstrated that ethanol/alcohol-induced disease is transmissible through fecal microbiota transplantation (FMT). So, the survival rate of people severe alcoholic hepatitis got better, which suggests makeup and function play a role metabolic The leaky intestinal barrier plays major influencing metabolic-related development microbiota. As result, viable bacteria products can be transported to liver, causing inflammation, contributing hepatocyte death, fibrotic response. starts gets worse, dysbiosis linked immune system, bile acid composition, gut. Metabolic-related disease, as well its self-perpetuation, will using data from human studies. Further, we summarize how untargeted treatment approaches affect including dietary changes, probiotics, antibiotics, FMT. It discusses targeted therapies improve various areas. These may options.

Language: Английский

Citations

0
p-Synephrine ameliorates non-alcoholic fatty liver disease by regulating liver-adipose axis via AMPK/NF-kappa B pathway DOI

Wei‐Feng Cai,

Qi-Cong Chen,

Qian Ni

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119890 - 119890

Published: April 1, 2025

Language: Английский

Citations

0
Coprococcus protects against high-fat diet-induced nonalcoholic fatty liver disease in mice DOI

Kaikai Lu,

Yimeng Zhou,

Lei He

et al.

Journal of Applied Microbiology, Journal Year: 2024, Volume and Issue: 135(6)

Published: June 1, 2024

Abstract Aims The incidence of nonalcoholic fatty liver disease (NAFLD) is increasing annually, leading to substantial medical and health burdens. Numerous studies have demonstrated the potential effectiveness intestinal probiotics as a treatment strategy for NAFLD. Therefore, objective this study identify probiotic Methods results In study, blood fecal samples were collected from 41 healthy volunteers 44 patients diagnosed with Analysis 16S rDNA sequencing data quantitative real-time PCR (RT-qPCR) revealed significant reduction in abundance Coprococcus NAFLD patients. Subsequent animal experiments that was able effectively reverse lipid accumulation, inflammation, fibrosis induced by high-fat diet (HFD) mice. Conclusions This provides first vivo evidence beneficial bacterium capable preventing has same effect mice Lactobacillus GG (LGG), positive control. serve prevention humans.

Language: Английский

Citations

3
Lactobacillus casei‐fermented Amomum xanthioides ameliorates metabolic dysfunction in high‐fat diet‐induced obese mice DOI
Jing‐Hua Wang, Seung‐Ju Hwang, Yujin Choi

et al.

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(10)

Published: May 15, 2024

Amomum xanthioides (AX) has been used as an edible herbal medicine to treat digestive system disorders in Asia. Additionally, Lactobacillus casei is a well-known probiotic commonly fermentation processes starter. The current study aimed investigate the potential of casei-fermented (LAX) alleviating metabolic induced by high-fat diet (HFD) mouse model. LAX significantly reduced body and fat weight, outperforming AX, yet without suppressing appetite. also markedly ameliorated excessive lipid accumulation inflammatory cytokine (IL-6) levels serum superior AX association with UCP1 activation adiponectin elevation. Furthermore, noticeably improved fasting blood glucose, insulin, HOMA-IR through positive regulation glucose transporters (GLUT2, GLUT4), insulin receptor gene expression. In conclusion, demonstrates pronounced mitigation overnutrition-induced dysfunction, including hyperlipidemia, hyperglycemia, hyperinsulinemia, obesity, compared non-fermented AX. Consequently, we proposed that holds promise candidate for effectively ameliorating disorders.

Language: Английский

Citations

1
Rate and Associated Factors of Fatigue in Chinese Patients with Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Survey DOI Creative Commons

Xian Du,

Jun Hu,

Jianhua Xue

et al.

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 2945 - 2953

Published: July 1, 2024

Fatigue was a common symptom of non-alcoholic fatty liver disease (NAFLD), which seriously affected patients' quality life. The aim this study to detect fatigue rate and evaluate factors associated with in NAFLD patients.

Language: Английский

Citations

0
Fermented rhubarb alleviates metabolic dysfunction-associated steatotic liver disease symptoms by modulating gut microbiota and activating the hepatic insulin signaling pathway DOI

Heng Yuan,

Junyu Zhou, Ting Zhang

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105720 - 105720

Published: Dec. 1, 2024

Language: Английский

Citations

0