Cited by Ferroptosis mediated inhibition of breast cancer cells by β–elemene incorporated GSH/pH dual responsive nanomicelles

An organ‐specific transcriptome atlas of Curcuma wenyujin: MicroRNAs, phasiRNAs, and metabolic pathways DOI

Xiaoxia Ma,

Y.-X. Tang,

Zedi Feng

et al.

The Plant Genome, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 7, 2025

Curcuma wenyujin Y. H. Chen et C. Ling (C. wenyujin) is a medicinal plant widely used for clinical treatments. In this study, integrated omics data analyses enabled us to discover the microRNAs (miRNAs) and phased small interfering RNAs (phasiRNAs) on transcriptome-wide scale. A total of 186 mature miRNAs 23 precursors were reported. Besides, 31 14 families organ-specifically expressed, 13 these could perform organ-specific target regulation. More than 80% phasiRNA loci especially in tubers. some cases, phasiRNAs with distinct increments, but accordant expression patterns, generated from highly overlapped region, indicating that different machineries might be synchronously engaged processing. Based transcriptome assembly, 28 56 tuber-specific genes identified involved alkaloid terpenoid metabolisms, respectively. Analysis enzyme-coding β-elemene biosynthetic pathway showed downstream tuber-specific, while upstream not. We assumed precursor metabolites produced other organs delivered tubers final steps biosynthesis. Summarily, our report provided an atlas wenyujin, which serve as basis molecular studies organ development secondary metabolisms plant.

Language: Английский

Citations

Novel agents derived from natural product β-elemene: A second round of design and synthesis to enhance antitumor properties DOI

Zhouyan Liu,

Tong Li, Chenglei Gu

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 121, P. 118129 - 118129

Published: Feb. 22, 2025

Language: Английский

Citations

β-elemene: A promising natural compound in lung cancer therapy DOI

Jiguang Bao, Zhiliang Li, D Zhang

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177399 - 177399

Published: March 1, 2025

Language: Английский

Citations

Introduction of human m6Am methyltransferase PCIF1 facilitates the biosynthesis of terpenoids in Saccharomyces cerevisiae DOI

Guoli Wang, Mingkai Li,

Baochen Fan

et al.

Microbial Cell Factories, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 2, 2025

Language: Английский

Citations

A novel benzofuran derivative of β-elemene (ZT-22) inhibits hepatocellular carcinoma cell growth via directly targeting HSPA6 DOI

Zhiqiang Luo,

Huixia Fan,

Tao Zhang

et al.

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111514 - 111514

Published: April 1, 2025

Language: Английский

Citations

Natural products target programmed cell death signaling mechanisms to treat colorectal cancer DOI

Ya Zheng, Na Feng,

C W Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 24, 2025

As a highly prevalent gastrointestinal malignant tumor, colorectal cancer poses serious challenge in terms of increasing morbidity and mortality late diagnosis due to the invisibility disease. Although existing therapies are diverse but limited efficacy, mechanism programmed cell death (PCD) has become focus research its central role maintaining body homeostasis regulating tumor progression. Multimodal pathways, such as apoptosis, autophagy, pyroptosis ferroptosis, have shown unique advantages inhibiting proliferation migration cells enhancing sensitivity chemotherapy by responding internal external environmental stimuli. In recent years, natural products risen prominence virtue their multi-target synergistic effects chemo-sensitizing properties, opened up new direction for treatment precisely PCD pathway. this paper, we searched PubMed, Web Science CNKI databases relevant studies last 10 years using keywords (Colorectal cancer) (programmed death) products. This work retrieved 59 (55 from past 5 4 years) reveal action targeting PCD, aiming provide theoretical support practical guidance optimization clinical therapeutic strategies development innovative drugs.

Language: Английский

Citations

The anti-metastatic effect of elemene in human hepatocellular carcinoma is potentially mediated by inhibiting a novel driver-circBPTF DOI

Mengyu Yang, Xiaoyu Chen, Yongqian Liu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156808 - 156808

Published: April 1, 2025

Language: Английский

Citations

Effects of natural products on angiogenesis in melanoma DOI

Xurui Wang,

E. Liu,

Changcheng Hou

et al.

Fitoterapia, Journal Year: 2024, Volume and Issue: 177, P. 106100 - 106100

Published: July 6, 2024

Language: Английский

Citations

Traditional Chinese medicine and its components effectively reduce resistance mediated by immune checkpoint inhibitors DOI

Mingxin Guo, Wentong Fang, Zhiqiang Hu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 26, 2024

Immunotherapy has become a global focus in cancer treatment and research, with promising results from targeting immune checkpoints tumors like non-small cell lung cancer, colon melanoma. However, resistance to checkpoint inhibitors (ICIs) remains significant challenge. Traditional Chinese medicine (TCM), known for its low toxicity minimal side effects, shows promise enhancing when combined modern therapies. This study reviews recent research on ICIs mechanisms highlights TCM's potential overcoming this resistance, aiming improve efficacy while minimizing toxicity.

Language: Английский

Citations

Ferroptosis Mediated Inhibition of Breast Cancer Cells by Β–Elemene Incorporated Gsh/Ph Dual Responsive Nanomicelles DOI

Shan Shen, Ran Xie,

Lingyu Jia

et al.

Published: Jan. 1, 2024

Language: Английский

Citations