Molecular Pathways Linking High-Fat Diet and PM2.5 Exposure to Metabolically Abnormal Obesity: A Systematic Review and Meta-Analysis DOI Creative Commons
Sagrario Lobato,

Víctor Manuel Salomón-Soto,

Claudia Méndez

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1607 - 1607

Published: Dec. 16, 2024

Obesity, influenced by environmental pollutants, can lead to complex metabolic disruptions. This systematic review and meta-analysis examined the molecular mechanisms underlying metabolically abnormal obesity caused exposure a high-fat diet (HFD) fine particulate matter (PM2.5). Following PRISMA guidelines, articles from 2019 2024 were gathered Scopus, Web of Science, PubMed, random-effects was performed, along with subgroup analyses pathway enrichment analyses. study registered in Open Science Framework. Thirty-three articles, mainly case–control studies murine models, reviewed, they revealed that combined HFD PM2.5 resulted greatest weight gain (82.835 g, p = 0.048), alongside increases high-density lipoproteins, insulin, superoxide dismutase. enriched pathways linked adipocytokine signaling brown adipose tissue, while impacted genes associated fat formation. Both exposures downregulated protein metabolism white tissue activated stress-response cardiac tissue. Peroxisome proliferator-activated receptor AMP-activated kinase liver enriched, influencing non-alcoholic fatty disease. These findings highlight amplifies body gain, oxidative stress, dysfunction, suggesting synergistic interaction significant implications for health.

Language: Английский

Primary structure analysis of cold water-soluble alcohol extract from green tea and the regulatory effects on intestinal flora metabolism DOI Creative Commons

Youshun Gong,

Na Guo, Keyao Dai

et al.

LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117313 - 117313

Published: Jan. 1, 2025

Language: Английский

Citations

0
Traditional Mongolian Medicine Qiqirigan-8 alleviates non-alcoholic fatty liver disease via restoring gut microbiota and metabolism DOI Creative Commons
Yang Dandan,

Wuyunsiqin,

YanNiu

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 27, 2025

Mongolian Medicine Qiqirigan-8 (MMQ-8) is a traditional medicine formula used to treat fatty liver disease. However, the material basis and in vivo metabolic process of therapeutic effect MMQ-8 on non-alcoholic disease (NAFLD) remain unclear. The chemical composition was determined using Ultra-high-performance liquid chromatography-quadrupole Exactive Mass spectrometry analysis (UHPLC-QE-MS). C57BL/6J mice were fed choline-deficient diet for 12 weeks induce NAFLD model. Hematoxylin Eosin (H&E)-staining, combined with serum biochemical indexes, observe appearance characterize pathological changes functions liver. HE staining Alcian Blue-Phosphoric Acid Schiff (AB-PAS) colon, along ZO-1 immunofluorescence expression colon reveal disruption intestinal epithelial mucosal barrier NAFLD. tight junction genes analyzed by qRT-PCR protective against disruption. Fecal metagenomics non-targeted metabolomics effects gut microbiota metabolism Finally, we emphasize interaction between metabolites through Spearman correlation coefficient analysis. contains 17 active ingredients, which can reduce hepatic steatosis lobular inflammation NAFLD, have injury. reduced infiltration inflammatory cells epithelium model while restoring number goblet cells. significantly enhanced protein as well mRNA both Occludin. results showed that Bacillota/Bacteroidota ratio mice. Increased abundance beneficial bacteria such Porphyromonadaceae, Prevotella, Bacteroidota. suppressed dysfunctional bacteria, Bacillota, Acetatifactor, Erysipelotrichaceae. Furthermore, studies revealed intervention regulated related glutathione metabolism, butyric acid sphingolipid glycerophospholipid compared group. These pathways play key roles According Spearman's analysis, up-regulation Bacteroidota after negatively correlated LPC levels pathways, positively PC levels. In contrast, relationship Bacillota down-regulated intervention, opposite. addition, fumaric acid, 2-oxoglutaric adenosine, L-glutathione levels, those Acetatifactor all above metabolites. Thus, microbial ecosystem are tightly intertwined this process. summary, these findings indicate has synergistic anti-NAFLD its multi-component, multi-target, microbiota-modulating multi pathway characteristics. host's regulation specific involvement multiple may be one important mechanisms exerts It worth noting closely

Language: Английский

Citations

0
Sirtuins and Gut Microbiota: Dynamics in Health and a Journey from Metabolic Dysfunction to Hepatocellular Carcinoma DOI Creative Commons
Mahmoud Zhra, Muhammad Affan Elahi, Aamira Tariq

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 466 - 466

Published: March 20, 2025

Metabolic dysfunction leading to non-alcoholic fatty liver disease (NAFLD) exhibits distinct molecular and immune signatures that are influenced by factors like gut microbiota. The microbiome interacts with the via a bidirectional relationship gut–liver axis. Microbial metabolites, sirtuins, responses pivotal in different metabolic diseases. This extensive review explores complex multifaceted interrelationship between sirtuins microbiota, highlighting their importance health disease, particularly hepatocellular carcinoma (HCC). Sirtuins (SIRTs), classified as group of NAD+-dependent deacetylases, serve crucial modulators wide spectrum cellular functions, including pathways, inflammatory response, process senescence. Their subcellular localization diverse functions link them various conditions, NAFLD cancer. Concurrently, comprising microorganisms, significantly influences host metabolism responses. Recent findings indicate modulate microbiota composition function, while can affect sirtuin activity. is relevant disorders, where dysbiosis contributes progression. highlights recent on roles specific maintaining implications HCC development. Understanding these interactions offers potential therapeutic avenues for managing diseases linked dysregulation pathology.

Language: Английский

Citations

0
Mechanisms of hepatic and renal injury in lipid metabolism disorders in metabolic syndrome DOI Creative Commons

Jin Rong,

Zixuan Zhang, Xiaoyu Peng

et al.

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(12), P. 4783 - 4798

Published: Jan. 1, 2024

Metabolic syndrome (MetS) is a group of metabolic abnormalities that identifies people at risk for diabetes and cardiovascular disease. MetS characterized by lipid disorders, non-alcoholic fatty liver disease (NAFLD) diabetic kidney (DKD) are thought to be the common hepatic renal manifestations following abnormal metabolism. This paper reviews molecular mechanisms deposition in NAFLD DKD, highlighting commonalities differences pathways DKD. Hepatic steatosis result acquisition exceeding processing, i.e., acid uptake regeneration exceed oxidation export. process directly regulated interactions nuclear receptors, transporter proteins transcription factors, whereas such as oxidative stress, autophagy, cellular pyroptosis gut flora also key regulatory hubs homeostasis but act slightly differently kidney. Such insights based on liver-kidney similarities offer potential options improved treatment.

Language: Английский

Citations

3
Radiation protection of sodium alginate and its regulatory effect on intestinal microflora in mice DOI

Zhangning Qiao,

Zhiying Li, Yanling Shi

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135809 - 135809

Published: Sept. 1, 2024

Language: Английский

Citations

1
Elaeagnus angustifolia L. fruit alleviates diarrhea via regulating intestinal microbiota and short chain fatty acids DOI Creative Commons

Xiatiguli Abulizi,

Minghui Shi,

Yue-Mei Jia

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e38646 - e38646

Published: Oct. 1, 2024

Language: Английский

Citations

1
Molecular Pathways Linking High-Fat Diet and PM2.5 Exposure to Metabolically Abnormal Obesity: A Systematic Review and Meta-Analysis DOI Creative Commons
Sagrario Lobato,

Víctor Manuel Salomón-Soto,

Claudia Méndez

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1607 - 1607

Published: Dec. 16, 2024

Obesity, influenced by environmental pollutants, can lead to complex metabolic disruptions. This systematic review and meta-analysis examined the molecular mechanisms underlying metabolically abnormal obesity caused exposure a high-fat diet (HFD) fine particulate matter (PM2.5). Following PRISMA guidelines, articles from 2019 2024 were gathered Scopus, Web of Science, PubMed, random-effects was performed, along with subgroup analyses pathway enrichment analyses. study registered in Open Science Framework. Thirty-three articles, mainly case–control studies murine models, reviewed, they revealed that combined HFD PM2.5 resulted greatest weight gain (82.835 g, p = 0.048), alongside increases high-density lipoproteins, insulin, superoxide dismutase. enriched pathways linked adipocytokine signaling brown adipose tissue, while impacted genes associated fat formation. Both exposures downregulated protein metabolism white tissue activated stress-response cardiac tissue. Peroxisome proliferator-activated receptor AMP-activated kinase liver enriched, influencing non-alcoholic fatty disease. These findings highlight amplifies body gain, oxidative stress, dysfunction, suggesting synergistic interaction significant implications for health.

Language: Английский

Citations

0