Deciphering the Roles of Non-Coding RNAs in Liposarcoma Development: Challenges and Opportunities for Translational Therapeutic Advances DOI Creative Commons
Zhi Xiong Chong, Wan Yong Ho, Swee Keong Yeap

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 11, P. 73 - 90

Published: Nov. 15, 2024

Liposarcoma is one of the most prevalent forms soft tissue sarcoma, and its prognosis highly dependent on molecular subtypes. Non-coding RNAs (ncRNAs) like microRNAs (miRNAs) long non-coding (lncRNAs) can bind various cellular targets to regulate carcinogenesis. By affecting expressions activities their downstream post-transcriptionally, dysregulations miRNAs alter different oncogenic signalling pathways, mediating liposarcoma progression. On contrary, lncRNAs sponge spare from translational repression, indirectly miRNA-regulated activities. In past 15 years, multiple fundamental clinical research has shown that ncRNAs play essential roles in modulating development. Yet, there a lack an effective review report could summarize findings studies. To narrow this literature gap, article aimed compare studies tumour-regulatory understand how control progression mechanistically. Additionally, reported were critically reviewed evaluate potentials applications, including employing these as diagnostic prognostic biomarkers or therapeutic management liposarcoma. Overall, over apoptosis, WNT/β-catenin, TGF-β/SMAD4, EMT, interleukin, YAP-associated pathways influence 28 be upregulated tissues circulation, whereas 11 downregulated, making them potential candidates biomarkers. Among ncRNAs, measuring circulating levels miR-155 miR-195 was help detect liposarcoma, differentiate subtypes, predict survival treatment response patients. except for few miR-195, current evidence support use discussed managing mainly based single-center study with relatively small sample sizes cell-based Hence, more large-scale multi-center should conducted further confirm sensitivity, specificity, safety targets. Instead furthering investigation values all which time- cost-consuming, it would practical focus if they are sensitive safe used agents

Language: Английский

A new era of cancer immunotherapy: vaccines and miRNAs DOI Creative Commons

Gitika Sareen,

Maneesh Mohan, Ashi Mannan

et al.

Cancer Immunology Immunotherapy, Journal Year: 2025, Volume and Issue: 74(5)

Published: April 1, 2025

Language: Английский

Citations

2
MiRNA-155: A double-edged sword in colorectal cancer progression and drug resistance mechanisms DOI Creative Commons
Bashdar Mahmud Hussen, Samia Aziz Sulaiman, Snur Rasool Abdullah

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 140134 - 140134

Published: Jan. 20, 2025

Language: Английский

Citations

0
Decoding the Promise and Challenges of miRNA-Based Cancer Therapies: An Essential Update on miR-21, miR-34, and miR-155 DOI Creative Commons
Hongbo Qian, Mazaher Maghsoudloo, Parham Jabbarzadeh Kaboli

et al.

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(14), P. 2781 - 2798

Published: Oct. 28, 2024

MicroRNAs (miRNAs)-based therapies hold great promise for cancer treatment, challenges such as expression variability, off-target effects, and limited clinical effectiveness have led to the withdrawal of many trials. This review investigates setbacks in miRNA-based by examining miR-21, miR-34, miR-155, highlighting their functional complexity, delivering these effectively. Moreover, It highlights recent advances delivery methods, combination therapies, personalized treatment approaches overcome challenges. intricate molecular networks involving miRNAs, particularly interactions with other non-coding RNAs, long RNAs (lncRNAs) circular (circRNAs), emphasizing pivotal role miRNAs biology therapeutic strategies. By addressing hurdles, this aims steer future research toward harnessing potential miRNA target pathways effectively, enhance anti-tumor responses, ultimately improve patient outcomes precision therapy.

Language: Английский

Citations

3
The role of miR-152 in urological tumors: potential biomarkers and therapeutic targets DOI Creative Commons
Xin Li,

Biao Qian,

Xu Chen

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 13, 2024

Urological malignant tumors pose a significant threat to human health, with high incidence rate each year. Prostate cancer, bladder and renal cell carcinoma are among the most prevalent extensively researched urological malignancies. Despite advancements in research, prognosis for these remains unfavorable due late detection, postoperative recurrence, treatment resistance. A thorough investigation into their pathogenesis is crucial early diagnosis treatment. Recent studies have highlighted close association between microRNAs (miRNAs) cancer progression. miRNAs small non-coding RNAs composed of 19-23 nucleotides that regulate gene expression by binding 3’ untranslated region (3’UTR) target mRNAs, impacting key cellular processes such as proliferation, differentiation, apoptosis, migration. Dysregulation can disrupt oncogenes tumor suppressor genes, contributing development. Among various studied, miR-152 has garnered attention its role Several indicated dysregulation cancers, warranting comprehensive review evidence. This focuses on function prostate carcinoma, elucidating mechanisms progression exploring potential therapeutic biomarker

Language: Английский

Citations

2
miR-137: a potential therapeutic target for lung cancer DOI Creative Commons

Shuanshuan Liu,

Yanyun Ruan, Xu Chen

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Aug. 23, 2024

Lung cancer is a prevalent malignancy and the leading cause of cancer-related deaths, posing significant threat to human health. Despite advancements in treatment, prognosis for lung patients remains poor due late diagnosis, recurrence, drug resistance. Epigenetic research, particularly microRNAs, has introduced new avenue prevention treatment. MicroRNAs, including miR-137, play vital role tumor development by regulating various cellular processes. MiR-137 garnered attention its tumor-suppressive properties, with studies showing potential inhibiting progression. In cancer, miR-137 particular interest, numerous reports exploring mechanisms. A comprehensive review necessary consolidate current evidence. This highlights recent on covering cell proliferation, migration, apoptosis, resistance, therapy, emphasizing as biomarker therapeutic target treatment prognosis.

Language: Английский

Citations

1
Deciphering the Roles of Non-Coding RNAs in Liposarcoma Development: Challenges and Opportunities for Translational Therapeutic Advances DOI Creative Commons
Zhi Xiong Chong, Wan Yong Ho, Swee Keong Yeap

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 11, P. 73 - 90

Published: Nov. 15, 2024

Liposarcoma is one of the most prevalent forms soft tissue sarcoma, and its prognosis highly dependent on molecular subtypes. Non-coding RNAs (ncRNAs) like microRNAs (miRNAs) long non-coding (lncRNAs) can bind various cellular targets to regulate carcinogenesis. By affecting expressions activities their downstream post-transcriptionally, dysregulations miRNAs alter different oncogenic signalling pathways, mediating liposarcoma progression. On contrary, lncRNAs sponge spare from translational repression, indirectly miRNA-regulated activities. In past 15 years, multiple fundamental clinical research has shown that ncRNAs play essential roles in modulating development. Yet, there a lack an effective review report could summarize findings studies. To narrow this literature gap, article aimed compare studies tumour-regulatory understand how control progression mechanistically. Additionally, reported were critically reviewed evaluate potentials applications, including employing these as diagnostic prognostic biomarkers or therapeutic management liposarcoma. Overall, over apoptosis, WNT/β-catenin, TGF-β/SMAD4, EMT, interleukin, YAP-associated pathways influence 28 be upregulated tissues circulation, whereas 11 downregulated, making them potential candidates biomarkers. Among ncRNAs, measuring circulating levels miR-155 miR-195 was help detect liposarcoma, differentiate subtypes, predict survival treatment response patients. except for few miR-195, current evidence support use discussed managing mainly based single-center study with relatively small sample sizes cell-based Hence, more large-scale multi-center should conducted further confirm sensitivity, specificity, safety targets. Instead furthering investigation values all which time- cost-consuming, it would practical focus if they are sensitive safe used agents

Language: Английский

Citations

0