Cinnamon for Metabolic Diseases and Their Cardiovascular and Hepatic Complications: A Mechanistic Review DOI

Junpeng Wu,

Wenhan Jia,

Dongyu Min

et al.

The American Journal of Chinese Medicine, Journal Year: 2024, Volume and Issue: 52(08), P. 2403 - 2421

Published: Jan. 1, 2024

Cinnamon is one of the world’s oldest and most popular spices, derived from inner bark several tree species genus Cinnamomum. During last two decades, cinnamon has demonstrated beneficial metabolic effects not only in animal experiments but also clinical trials. Even recent meta-analyses have shown protective on different components syndrome their complications. In 5 years, experimental studies unraveled intricate molecular mechanisms underlying antihypertensive, antihyperglycemic, lipid-lowering, weight-lowering, cardioprotective properties cinnamon. This review paper will discuss how its active components, particularly cinnamaldehyde, suppress inflammation oxidative stress, modulate mitochondrial dysfunction, regulate glucose uptake, insulin resistance, lipogenesis, beta-oxidation, Ca2+ signaling, other cellar events at level. Specifically, we delve into involved to provide a deeper insight can bring such effects. hopes encourage use settings, guide combination with drugs used treat based mechanism action, support concept complementary medicine for diseases.

Language: Английский

Imperatorin’s Effect on Myocardial Infarction Based on Network Pharmacology and Molecular Docking DOI Creative Commons
Ruihai Zhang, Peng Wang,

Yao Jin

et al.

Cardiovascular Therapeutics, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Purpose: Myocardial infarction (MI), a severe cardiovascular disease, is the result of insufficient blood supply to myocardium. Despite improvements conventional therapies, new approaches are needed improve outcome post-MI. Imperatorin natural compound with multiple pharmacological properties and potential cardioprotective effects. Therefore, this work investigated imperatorin's therapeutic effects its mechanism action in an MI mouse model. Methods: Network pharmacology, molecular docking, experimental validation were performed for exploring pharmacokinetic properties, effects, targets imperatorin MI. Permanent ligation left anterior descending artery was male C57BL/6 mice induce before treatment once per day 1 week. Echocardiography, heart histology, RNA sequencing, quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) as well western blotting carried out evaluating cardiac function structure, gene protein expression. Results: significantly improved function, preserved attenuated remodeling fibrosis, reduced cardiomyocyte apoptosis mice. Eight differentially expressed genes overlapping key target found, two upregulated six downregulated. A signaling pathways associated effect angiotensin-converting enzyme (ACE). inhibited ACE-angiotensin II (Ang II)-angiotensin Type receptor (AT1R) axis Conclusion: by inhibiting ACE-Ang II-AT1R axis. Thus, might be considered agent cure

Language: Английский

Citations

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Chinese and western medicine treatment of myocardial fibrosis drugs DOI Creative Commons
Yuxi Zhu, Fangmei Zhang, Zhongcheng Li

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 15, 2025

Myocardial fibrosis (MF) is a common pathological manifestation of many cardiovascular diseases, such as myocardial infarction, ischemia, and sudden cardiac death. It characterized by excessive proliferation activation fibroblasts, transformation into myofibroblasts, and, eventually, deposition the extracellular matrix, resulting in heart damage. Currently, modern drugs angiotensin-converting enzyme inhibitors, diuretics, β-blockers can improve clinical treatment, but their therapeutic effect on this disease limited, with obvious side effects high cost. Traditional Chinese medicine (TCM) has advantages multiple targets, low cost, few effects. medicines, Salvia miltiorrhiza, Astragalus, Angelica extracts, patent Qiliqiangxin capsules, Shenqi Yiqi dropping pills, Tongxinluo fibrosis. In review, current Western methods for treating are discussed. The signaling pathways targets involved treatment This review aimed to provide valuable insights ideas both basic research

Language: Английский

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Патогенетичні механізми розвитку кардіофіброзу при фібриляції передсердь DOI Open Access
Eugene O. Perepeka, V. V. Lazoryshynets

Ukrainian Journal of Cardiology, Journal Year: 2025, Volume and Issue: 32(1), P. 54 - 63

Published: Feb. 26, 2025

The study of the pathogenesis and pathomorphology cardiofibrosis can be reffered to one important problems in modern cardiology. This review paper presents data on different stages development atrial fibrillation (AF). Its significant advantage lies molecular mechanisms occurrence disease from its initial final stages. It has been established that a number activated intracellular signaling pathways profibrotic factors play role cardiofibrosis. Their interaction leads induction progression this pathological process. work also includes consistent detailed analysis cytological aspects AF. Important conditions cause activation fibroblasts acceleration fibrotic process are changes state connective tissue cells, cardiomyocytes other types resident heart cells. They directly involved regulation gene expression necessary for synthesis specific proteins formation fibrous shown proliferation matrix, inflammation, oxidative stress, necrosis cardiomyocytes, fibrosis remodeling subsequently observed at structural histopathological follow period functional metabolic disorders atria Thus, it should expected future results relevant cardiological studies will create scientific prerequisites innovative drugs technologies. allow not only effectively treat patients with AF, but influence processes failure.

Language: Английский

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The Role of Signalling Pathways in Myocardial Fibrosis in Hypertrophic Cardiomyopathy DOI Creative Commons
Patryk Skórka,

Jakub Piotrowski,

Estera Bakinowska

et al.

Reviews in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 21, 2025

Hypertrophic cardiomyopathy (HCM) is the most prevalent hereditary cardiovascular disorder, characterised by left ventricular hypertrophy and cardiac fibrosis. Cardiac fibroblasts, transformed into myofibroblasts, play a crucial role in development of However, interactions between cardiomyocytes, immune cells are considered major mechanisms driving fibrosis progression. While disease has strong genetic background, its pathogenetic remain complex not fully understood. Several signalling pathways implicated development. Among these, transforming growth factor-beta angiotensin II frequently studied context In this review, we summarise current evidence on involvement pathogenesis HCM. Additionally, discuss potential monitoring pro-fibrotic molecules predicting clinical outcomes patients with

Language: Английский

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PDGFC secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and immunosuppression in lung adenocarcinoma DOI Creative Commons

Meimei Cui,

Xiaodi Ding,

Yu Jiang

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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The Role of the MAPK Signaling Pathway in Cardiovascular Disease: Pathophysiological Mechanisms and Clinical Therapy DOI Open Access
Xueyang Wang, Ruiqi Liu, Dan Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2667 - 2667

Published: March 16, 2025

Cardiovascular disease (CVD) is a serious global health issue with high mortality rates worldwide. Despite the numerous advancements in study of CVD pathogenesis recent years, further summarization and elaboration specific molecular pathways are required. An extensive body research has been conducted to elucidate association between MAPK signaling pathway, which present all eukaryotic organisms, cardiovascular disease. This review aims provide comprehensive summary on over past five years. The primary focus four diseases: heart failure, atherosclerosis, myocardial ischemia–reperfusion injury, cardiac hypertrophy. will also address pathophysiological mechanisms diseases, objective proposing novel clinical treatment strategies for CVD.

Language: Английский

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Research progress and prospect of MAPK signaling pathway in knee osteoarthritis DOI Creative Commons
Fan Qiao, Mingyu Zhao, Xiangdong Zhang

et al.

European Journal of Orthopaedic Surgery & Traumatology, Journal Year: 2025, Volume and Issue: 35(1)

Published: March 26, 2025

The knee joint, one of the most vulnerable joints in human body, is susceptible to degenerative changes due factors such as aging, obesity, trauma, inflammation, and genetic predisposition. These contribute primary or secondary degeneration joint cartilage bone hyperplasia. Knee osteoarthritis (KOA), a prevalent condition particularly among elderly, significantly impacts patients' quality life. Aberrant activation cellular signaling pathways, namely NF-κB, MAPK, Wnt has been identified key factor pathogenesis KOA. pathways degradation, disruption anabolic-catabolic balance within articular cartilage. Understanding precise roles these crucial for developing targeted therapies prevent treat OA. Therefore, further exploration essential develop more effective therapeutic strategies.

Language: Английский

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Mitochondrial function: A new direction for the targeted treatment of cardiovascular diseases with Chinese herbal medicine DOI Creative Commons
Lin Yang, Liang Wang, Baofeng Yang

et al.

Journal of Holistic Integrative Pharmacy, Journal Year: 2025, Volume and Issue: 6(1), P. 91 - 104

Published: March 1, 2025

Language: Английский

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Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology DOI Creative Commons
Luwen Zhang, Wei Wang,

Xincan Liu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 2, 2025

Cardiovascular disease poses a significant risk to human health and remains the leading cause of illness death globally, with its incidence continuing rise. The intricate pathophysiological mechanisms CVDs include inflammation, oxidative stress, autophagy, myocardial fibrosis. In light these underlying mechanisms, traditional Chinese medicine (TCM) constituents have demonstrated distinct advantages in managing CVDs. By exerting synergistic effects across multiple components targets, can modulate inflammatory response, mitigate regulate excessive enhance fibrosis repair. This article reviews latest advancements understanding how TCM compounds signaling pathways involved treatment

Language: Английский

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From Skeletal Muscle to Myocardium: Molecular Mechanisms of Exercise-Induced Irisin Regulation of Cardiac Fibrosis DOI Open Access
Zhao Wang, Lin Li, Meng Yang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3550 - 3550

Published: April 10, 2025

This study systematically elucidates the regulatory mechanisms and potential therapeutic value of exercise-induced hormone Irisin in pathological progression cardiac fibrosis. Through comprehensive analysis multidimensional data integration, we constructed a complete network within cardiovascular system, spanning its secretion, signal transduction, precise control. Our findings demonstrate that exercise intervention significantly elevates circulating levels via skeletal muscle–peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α)–fibronectin type III domain-containing protein 5 (FNDC5) signaling axis. establishes molecular barrier against fibrosis by targeting Sirtuin 1 (Sirt1) activation, inhibiting transforming growth factor-beta (TGF-β)/Smad3 pathway, modulating transcriptional activity mitochondrial biogenesis core factors PGC-1α nuclear respiratory factor (NRF-1). Moreover, dual mechanism exercise–skeletal muscle–heart axis not only effectively suppresses aberrant activation fibroblasts but also reduces collagen deposition, oxidative stress, inflammatory infiltration restoring dynamics balance. Taken together, this reveals novel exercise-mediated cardioprotective at interaction level, thereby providing theoretical basis for development non-pharmacological bio-intervention strategies pathway laying translational foundation prescriptions diseases.

Language: Английский

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