The American Journal of Chinese Medicine,
Journal Year:
2024,
Volume and Issue:
52(08), P. 2403 - 2421
Published: Jan. 1, 2024
Cinnamon
is
one
of
the
world’s
oldest
and
most
popular
spices,
derived
from
inner
bark
several
tree
species
genus
Cinnamomum.
During
last
two
decades,
cinnamon
has
demonstrated
beneficial
metabolic
effects
not
only
in
animal
experiments
but
also
clinical
trials.
Even
recent
meta-analyses
have
shown
protective
on
different
components
syndrome
their
complications.
In
5
years,
experimental
studies
unraveled
intricate
molecular
mechanisms
underlying
antihypertensive,
antihyperglycemic,
lipid-lowering,
weight-lowering,
cardioprotective
properties
cinnamon.
This
review
paper
will
discuss
how
its
active
components,
particularly
cinnamaldehyde,
suppress
inflammation
oxidative
stress,
modulate
mitochondrial
dysfunction,
regulate
glucose
uptake,
insulin
resistance,
lipogenesis,
beta-oxidation,
Ca2+
signaling,
other
cellar
events
at
level.
Specifically,
we
delve
into
involved
to
provide
a
deeper
insight
can
bring
such
effects.
hopes
encourage
use
settings,
guide
combination
with
drugs
used
treat
based
mechanism
action,
support
concept
complementary
medicine
for
diseases.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 12, 2024
Abstract
Aging
is
a
major
risk
factor
for
cardiovascular
disease,
the
leading
cause
of
death
worldwide,
and
numerous
other
diseases,
but
mechanisms
these
aging-related
effects
remain
elusive.
Chronic
changes
in
microenvironment
paracrine
signaling
behaviors
have
been
implicated,
understudied.
Here,
first
time,
we
directly
compare
extracellular
vesicles
obtained
from
young
aged
patients
to
identify
therapeutic
or
disease-associated
agents,
isolated
heart
tissue
matrix
(TEVs)
plasma
(PEVs).
While
EVs
showed
notable
overlap
miRNA
cargo,
differed
substantially,
indicating
differential
age-related
between
TEVs
PEVs.
overall
were
uniquely
enriched
miRNAs
which
indirectly
demonstrate
cardioprotective
effects,
with
45
potential
agents
implicated
our
analysis.
Both
populations
also
increased
predisposition
disease
aging,
though
through
different
mechanisms.
PEVs
largely
correlated
chronic
systemic
inflammation,
while
more
related
cardiac
homeostasis
local
inflammation.
From
this,
17
protein
targets
unique
as
likely
contribute
development
disease.
The American Journal of Chinese Medicine,
Journal Year:
2024,
Volume and Issue:
52(08), P. 2403 - 2421
Published: Jan. 1, 2024
Cinnamon
is
one
of
the
world’s
oldest
and
most
popular
spices,
derived
from
inner
bark
several
tree
species
genus
Cinnamomum.
During
last
two
decades,
cinnamon
has
demonstrated
beneficial
metabolic
effects
not
only
in
animal
experiments
but
also
clinical
trials.
Even
recent
meta-analyses
have
shown
protective
on
different
components
syndrome
their
complications.
In
5
years,
experimental
studies
unraveled
intricate
molecular
mechanisms
underlying
antihypertensive,
antihyperglycemic,
lipid-lowering,
weight-lowering,
cardioprotective
properties
cinnamon.
This
review
paper
will
discuss
how
its
active
components,
particularly
cinnamaldehyde,
suppress
inflammation
oxidative
stress,
modulate
mitochondrial
dysfunction,
regulate
glucose
uptake,
insulin
resistance,
lipogenesis,
beta-oxidation,
Ca2+
signaling,
other
cellar
events
at
level.
Specifically,
we
delve
into
involved
to
provide
a
deeper
insight
can
bring
such
effects.
hopes
encourage
use
settings,
guide
combination
with
drugs
used
treat
based
mechanism
action,
support
concept
complementary
medicine
for
diseases.
