Effect of cannabinoids on the efficacy and side effects of anticancer therapeutic strategies – Current status of preclinical and clinical research

Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 108851 - 108851

Published: April 1, 2025

Language: Английский

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Exploring the therapeutic potential of cannabinoids in cancer by modulating signaling pathways and addressing clinical challenges

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 27, 2024

Language: Английский

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Role of dasatinib in the management of lung cancer: A meta-analysis of clinical trials

Biomedical Reports, Journal Year: 2025, Volume and Issue: 22(3)

Published: Jan. 23, 2025

Lung cancer, particularly non-small cell lung cancer (NSCLC), the leading cause of cancer-related deaths worldwide, has prompted extensive research into innovative treatments, including targeted therapies. The present meta-analysis aims to evaluate efficacy dasatinib, both as monotherapy and in combination with other therapies, for treatment cancer. Adhering PRISMA guidelines, a meticulous, thorough review clinical trials was conducted across reputable databases, Google Scholar, PubMed/MEDLINE, EMBASE, focusing on studies published English up May 5th, 2024. Inclusion criteria were restricted randomized (RCTs) assessing either standalone therapy or treatments. search identified 55 studies, which nine RCTs met inclusion criteria: four phase II, three I, two I/II. A total 234 patients participated, 107 receiving dasatinib alone 127 undergoing therapy. Histological analyses revealed that 79.1% had adenocarcinoma being predominant subtype (63.8%), followed by squamous carcinoma (22.1%). Treatment responses varied, 52.4% group experiencing progressive disease, while 38.3% achieved stable disease; contrast, 29.6% showed disease. Adverse events, anemia fatigue, more prevalent Dasatinib shows potential improving overall survival fewer adverse events compared therapies cancer; however, large-scale are essential confirm its treatment.

Language: Английский

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Cannabinoids as Promising Inhibitors of HER2-Tyrosine Kinase: A Novel Strategy for Targeting HER2-Positive Ovarian Cancer

ACS Omega, Journal Year: 2025, Volume and Issue: 10(6), P. 6191 - 6200

Published: Feb. 8, 2025

Human epidermal growth factor receptor 2 (HER2) is a transmembrane within the ErbB family that plays pivotal role in progression of various aggressive cancers. HER2-positive tumors often develop resistance to standard therapies, necessitating exploration innovative treatment options. Cannabinoids, bioactive compounds from Cannabis sativa such as cannabidiol (CBD), cannabigerol (CBG), and cannabinol (CBN), have gained attention for their potential anticancer properties. This study evaluates efficacy CBD, CBG, CBN targeting ovarian cancer through kinase inhibition assays, surface plasmon resonance (SPR), molecular docking, cell viability assessments. SPR analysis revealed cannabinoids bind strongly HER2-tyrosine (HER2-TK), with CBD showing highest affinity (K D = 6.16 μM), significantly better than afatinib 26.30 CBG demonstrating moderate 17.07 μM). In was most potent inhibitor (IC50 24.7 nM), followed by 38 suggesting ability disrupt HER2-mediated signaling pathways. Molecular docking studies highlighted critical interactions between essential HER2 residues (Leu796, Thr862, Asp863). effectively inhibited SKOV3 cells 13.8 μM 16.6 μM, respectively), comparable traditional tyrosine inhibitors. These findings underscore therapeutic cannabinoids, particularly alternative or adjunct therapies cancers, promise mitigating adverse effects associated existing treatments.

Language: Английский

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Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Cellular senescence is characterized by a sustained and irreversible cessation of cell proliferation in response to diverse environmental stimuli. However, senescent cells exhibit strong metabolic activity release range cytokines inflammatory mediators into the tumor microenvironment, collectively referred as senescence‐associated secretory phenotype (SASP). In recent years, develop new therapies for cancers, researchers have conducted extensive studies on mechanism cancer revealed that induction could effectively suppress progression. it has been documented cellular not only inhibits initiation but also contributes significantly progression some cases. Hence, imperative comprehend correlation between tumorigenesis, discuss potential utilization mechanisms progression, which lays theoretical foundation drugs treat cancers. this review, we first provide an overview discovery its key milestone events. Meanwhile, review examines major stimulus senescence, provides categorization senescence. Subsequently, examination primary regulatory discussed, followed summary control SASP expression dual biological roles Additionally, common biomarkers utilized identification Finally, investigates efficacy “One‐Two punch” sequential treatment approach emerging challenges novel approach.

Language: Английский

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Cannabidiol Enhances the Anticancer Activity of Etoposide on Prostate Cancer Cells

Cannabis and Cannabinoid Research, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 20, 2024

extract has been used as an herbal medicine since ancient times. It is one of the most researched extracts, especially among supportive treatments against cancer. Prostate cancer frequently diagnosed types in men worldwide and estimated 288,300 new cases were 2023. Today, many advanced therapeutic approaches are for prostate cancer, such immunotherapy chemotherapy, but acquired drug resistance, long-term usage differentiation cells mostly restricted efficiency therapies. Therefore, it thought that use natural products to overcome these limitations improve effectiveness existing therapies may offer promising approaches. The present study focused on investigation possible enhancer role cannabidiol (CBD), which a potent ingredient compound Cannabis, chemotherapeutic agent etoposide cells.

Language: Английский

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Cannabidiol suppresses silica-induced pulmonary inflammation and fibrosis through regulating NLRP3/TGF-β1/Smad2/3 pathway

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113088 - 113088

Published: Sept. 7, 2024

Language: Английский

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SKI-606, a Src inhibitor, ameliorates benzene-induced hematotoxicity via blocking ROS/Src kinase-mediated p38 and Akt signaling pathways

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 286, P. 117223 - 117223

Published: Oct. 23, 2024

Language: Английский

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