The Novel Effect and Potential Mechanism of Lactoferrin on Organ Fibrosis Prevention

Nutrients, Journal Year: 2025, Volume and Issue: 17(1), P. 197 - 197

Published: Jan. 6, 2025

Organ fibrosis is gradually becoming a human health and safety problem, various organs of the body are likely to develop fibrosis. The ultimate pathological feature numerous chronic diseases fibrosis, few interventions currently available specifically target pathogenesis medical detection organ has matured. However, there no effective treatment method for these diseases. Therefore, we need strive developing reliable drugs or substances treat prevent fibrotic Lactoferrin (LF) multifunctional glycoprotein with many physiologically active effects, such as antioxidant, anti-inflammatory antimicrobial it protects against physiological conditions in disease models. This review summarizes effects underlying mechanisms LF preventing As naturally substance, can be used promising drug prevention remission

Language: Английский

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Lactoferrin targeting INTL1 receptor inhibits hepatocellular carcinoma progression via apoptosis and cell cycle signaling pathways

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 28, 2024

Language: Английский

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MicroRNA Signature in an In Vitro Keratinocyte Model of Diabetic Wound Healing

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10125 - 10125

Published: Sept. 20, 2024

Treating diabetic wounds effectively remains a significant clinical challenge. Emerging studies suggest that microRNAs (miRNAs) play crucial roles in various physiological and pathological processes hold promise as therapeutic tools. This study investigates the miRNA expression profile keratinocytes using cell model of wounds. Microarray analysis revealed 43 miRNAs from wounded incubated under conditions (high glucose/hypoxia) exhibited two-fold change compared to those normal (low glucose/normoxia). Quantitative RT-PCR confirmed differences eight miRNAs, with miR-3138 miR-3679-5p being further analyzed for their keratinocyte migration. Transfection mimic inhibitor indicated upregulation downregulation enhance migration both Pathway gene ontology (GO) analyses identified potential pathways functional annotations associated wound healing. Potential human targets were predicted three-way comparison TargetScan, miRDB, DIANA databases. elucidates signature diabetes-like environment, providing deeper insights into pathogenesis

Language: Английский

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Kefir peptides mitigate L-NAME-induced preeclampsia in rats through modulating hypertension and endothelial dysfunction

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117592 - 117592

Published: Oct. 28, 2024

Language: Английский

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