Insights into the Cardioprotective Effects of Pyridoxine Treatment in Diabetic Rats: A Study on Cardiac Oxidative Stress, Cardiometabolic Status, and Cardiovascular Biomarkers DOI Creative Commons
Slavica Mutavdžin, Kristina Gopčević, Sanja Stanković

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(14), P. 1507 - 1507

Published: July 12, 2024

The aims of this study were to examine the effects pyridoxine administration on activities cardiac antioxidant stress enzymes superoxide dismutase (SOD) and catalase (CAT) enzyme indicators cardiometabolic status, lactate malate dehydrogenase (LDH, MDH), as well LDH MDH isoforms' distribution in tissue healthy diabetic Wistar male rats. Experimental animals divided into five groups: C1-control (0.9% sodium chloride-NaCl-1 mL/kg, intraperitoneally (i.p.), 1 day); C2-second control NaCl i.p., 28 days); DM-diabetes mellitus (streptozotocin 100 mg/kg 0.9% NaCl, P-pyridoxine (7 mg/kg, DM + P-diabetes day 7 days). Pyridoxine treatment reduced CAT activity In rats, increased LDH1 decreased LDH4 isoform activities, peroxisomal mitochondrial activities. Our findings highlight positive complex interplay between oxidative stress, enzymes, metabolic changes cardiomyopathy.

Language: Английский

Tauroursodeoxycholic acid inhibits endothelial-mesenchymal transition in high glucose-treated human umbilical vein endothelial cells DOI
Yuan Liu, Tongxin Liu, Xin‐Hao Li

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: unknown, P. 102764 - 102764

Published: Jan. 1, 2025

Language: Английский

Citations

0
Icariin alleviates cardiomyocyte pyroptosis through AMPK-NLRP3 pathway to ameliorates diabetic cardiomyopathy DOI
Zhenhao Cai, Fengnan Sun, Qingyan Wang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114690 - 114690

Published: April 21, 2025

Language: Английский

Citations

0
Loganin ameliorates left ventricular fibrosis and dysfunction induced by pressure overload via the Sirt1/AKT/TGF-β1 signaling pathway DOI
Changbin Wang, Xiaoli Jiang, Shuhua Han

et al.

Journal of Natural Medicines, Journal Year: 2025, Volume and Issue: unknown

Published: May 10, 2025

Language: Английский

Citations

0
Insights into the Cardioprotective Effects of Pyridoxine Treatment in Diabetic Rats: A Study on Cardiac Oxidative Stress, Cardiometabolic Status, and Cardiovascular Biomarkers DOI Creative Commons
Slavica Mutavdžin, Kristina Gopčević, Sanja Stanković

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(14), P. 1507 - 1507

Published: July 12, 2024

The aims of this study were to examine the effects pyridoxine administration on activities cardiac antioxidant stress enzymes superoxide dismutase (SOD) and catalase (CAT) enzyme indicators cardiometabolic status, lactate malate dehydrogenase (LDH, MDH), as well LDH MDH isoforms' distribution in tissue healthy diabetic Wistar male rats. Experimental animals divided into five groups: C1-control (0.9% sodium chloride-NaCl-1 mL/kg, intraperitoneally (i.p.), 1 day); C2-second control NaCl i.p., 28 days); DM-diabetes mellitus (streptozotocin 100 mg/kg 0.9% NaCl, P-pyridoxine (7 mg/kg, DM + P-diabetes day 7 days). Pyridoxine treatment reduced CAT activity In rats, increased LDH1 decreased LDH4 isoform activities, peroxisomal mitochondrial activities. Our findings highlight positive complex interplay between oxidative stress, enzymes, metabolic changes cardiomyopathy.

Language: Английский

Citations

1