Nanoscale Advances, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
This review explores the synergistic administration of miRNA and chemotherapeutic agents to combat drug resistance in breast cancer, emphasizing cutting-edge delivery systems their profound implications for clinical outcomes.
Language: Английский
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 26, 2025
Abstract The central nervous system (CNS) diseases are major contributors to death and disability worldwide. However, the blood–brain barrier (BBB) often prevents drugs intended for CNS from effectively crossing into brain parenchyma deliver their therapeutic effects. is a semi-permeable with high selectivity. BBB primarily manages transport of substances between blood CNS. To enhance drug delivery disease treatment, various brain-based strategies overcoming have been developed. Among them, nanoparticles (NPs) emphasized due multiple excellent properties. This review starts an overview BBB’s anatomical structure physiological roles, then explores mechanisms, both endogenous exogenous, that facilitate NP passage across BBB. text also delves how nanoparticles' shape, charge, size, surface ligands affect ability cross offers different nanoparticle classifications. concludes examination current challenges in utilizing nanomaterials discusses corresponding directions solutions. aims propose innovative diagnostic approaches design more effective Graphical abstract
Language: Английский
Citations
3
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 116899 - 116899
Published: June 17, 2024
Neurodegenerative diseases that include Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's (PD), Huntington's (HD), and multiple (MS) arise due to numerous causes like protein accumulation autoimmunity characterized by neurologic depletion which lead incapacity in normal physiological function such as thinking movement these patients. Glial cells perform an important role protective neuronal function; the case of neuroinflammation, glial cell dysfunction can promote development neurodegenerative diseases. miRNA participates gene regulation plays a vital many biological processes body; central nervous system (CNS), it play essential part neural maturation differentiation. In diseases, dysregulation occurs, enhancing this review, we discuss (Alzheimer's (MS)) how is preserved diagnostic biomarker or therapeutic agent disorders. Finally, highlight therapy.
Language: Английский
Citations
13
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139532 - 139532
Published: Jan. 5, 2025
Language: Английский
Citations
1
Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 29, 2025
Language: Английский
Citations
0
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: March 18, 2025
Language: Английский
Citations
0
ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(16)
Published: April 1, 2025
Abstract Layered double hydroxides (LDHs) are emerging as versatile, nonviral vectors for gene delivery, offering significant potential in therapeutic applications. Their structure comprises positively charged metal hydroxide layers intercalated with anions, enabling efficient encapsulation of genetic materials like plasmids, small interfering RNA (siRNA), and messenger (mRNA). The anionic exchange capacity LDHs allows the controlled release nucleic acids, positioning them promising tools precision therapy. tunable composition enable optimization particle size, charge density, degradation rates to meet specific requirements. At cellular level, taken up via endocytosis, followed by intracellular trafficking, pH‐triggered material. This process protects acids from enzymatic ensures delivery cytoplasm or nucleus. They have successfully encapsulated siRNA effective silencing vitro vivo, downregulating disease‐associated genes conditions cystic fibrosis, muscular dystrophy, chronic viral infections. With their structural versatility, biocompatibility, acid poised revolutionize therapy personalized medicine, providing a safer alternative vectors. review highlights innovative carriers emphasizing structure, versatility targeted
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1366 - 1366
Published: Oct. 25, 2024
The COVID-19 pandemic has significantly accelerated progress in RNA-based therapeutics, particularly through the successful development and global rollout of mRNA vaccines. This review delves into transformative impact on RNA with a strong focus lipid nanoparticles (LNPs) as pivotal delivery platform. LNPs have proven to be critical enhancing stability, bioavailability, targeted mRNA, facilitating unprecedented success vaccines like those developed by Pfizer-BioNTech Moderna. Beyond vaccines, LNP technology is being explored for broader therapeutic applications, including treatments cancer, rare genetic disorders, infectious diseases. also discusses emerging systems, such polymeric viral vectors, which offer alternative strategies overcome existing challenges related immune responses, tissue-specific targeting. Additionally, we examine pandemic's influence regulatory processes, fast-tracked approvals therapies, surge research funding that spurred further innovation field. Public acceptance grown, laying groundwork future developments personalized medicine. By providing an in-depth analysis these advancements, this highlights long-term evolution therapeutics precision drug technologies.
Language: Английский
Citations
1
Nanoscale Advances, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
This review explores the synergistic administration of miRNA and chemotherapeutic agents to combat drug resistance in breast cancer, emphasizing cutting-edge delivery systems their profound implications for clinical outcomes.
Language: Английский
Citations
0