Bioactive Compounds and Their Chondroprotective Effects for Osteoarthritis Amelioration: A Focus on Nanotherapeutic Strategies, Epigenetic Modifications, and Gut Microbiota DOI Open Access

Kota Sri Naga Hridayanka,

Asim K. Duttaroy, Sanjay Basak

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3587 - 3587

Published: Oct. 22, 2024

In degenerative joint disease like osteoarthritis (OA), bioactive compounds resveratrol, epigallocatechin gallate, curcumin, and other polyphenols often target various signalling pathways, including NFκB, TGFβ, Wnt/β-catenin by executing epigenetic-modifying activities. Epigenetic modulation can genes of pathophysiology via histone modification, promoter DNA methylation, non-coding RNA expression, some which are directly involved in OA but have been less explored. patients seek options that improve the quality their life addition to existing treatment with nonsteroidal anti-inflammatory drugs (NSAIDs). Although natural exhibit therapeutic potential against OA, several disadvantages loom, insolubility poor bioavailability. Nanoformulated promise a better way alleviate since they also control systemic events, metabolic, immunological, inflammatory responses, modulating host gut microbiota regulate pathogenesis. Recent data suggest dysbiosis OA. However, limited evidence is available on role as epigenetic modulators ameliorating Moreover, it not known whether effects polyphenolic microbial response mediated modulatory activities This narrative review highlights nanotherapeutic strategies utilizing compounds, reporting chondrocyte growth, metabolism, modifications amelioration.

Language: Английский

Research progress on pharmacokinetics, anti-inflammatory and immunomodulatory effects of kaempferol DOI

Suiran Li,

Siwei Wang, Lei Zhang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114387 - 114387

Published: March 6, 2025

Language: Английский

Citations

1
Exploring the Potential Pharmacological Mechanism of Huiyang Zhitong Plaster in Treating Knee Osteoarthritis through Network Pharmacology, Molecular Docking, and Experimental Validation DOI Creative Commons

Qifan Su,

Xiaoyu Chen, Xiaoming Zhang

et al.

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION), Journal Year: 2025, Volume and Issue: unknown, P. 100492 - 100492

Published: Jan. 1, 2025

Language: Английский

Citations

0
Baicalin and Kaempferol Alleviates Cuprizone-Induced Demyelination and Microglial Activation by Inhibiting the Stat3 and Nf-Κb Signaling Pathways DOI
Liming Liu, Yufang Zhao,

Jingjing Bu

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Unraveling the Molecular Mechanisms of Osteoarthritis: The Potential of Polyphenols as Therapeutic Agents DOI Open Access
Syed Nasar Rahaman,

Murugesan Lishadevi,

Suresh Kumar Anandasadagopan

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

The complex nature of osteoarthritis (OA), driven by the intricate interplay genetic, environmental, and lifestyle factors, necessitates development a single treatment method, which is highly challenging. long-term use non-steroidal anti-inflammatory drugs (NSAIDs) corticosteroids often leads to adverse side effects like kidney damage stomach ulcers. Major health threats obesity aging create milieu chronic low-grade inflammation increased mechanical stress on joints resulting in cartilage deterioration. Additionally, postmenopausal women with lower circulating 17β-estradiol levels experience accelerated joint deterioration due immune activity production pro-inflammatory cytokines, elevated MMP expression decreased type II collagen synthesis. Polyphenols are nature's gifted magic molecules, possess diverse biological properties anti-oxidant, anti-bacterial, anti-inflammatory, estrogenic, insulin-sensitizing effects, can manage treat all multi-factorial contributing factors OA effectively. Certain polyphenols act as phytoestrogens mimic natural estrogen binding ERα ERβ SERMs prevent degradation articular thereby alleviating osteoarthritic conditions. These molecules downregulate various apoptotic genes, matrix-degrading proteases (MMPs) while upregulating major ECM proteins collagen, aggrecan, proteoglycans animal models. This review provides comprehensive overview molecular mechanisms involved also explores therapeutic potential different mitigating their protective effect inhibiting extracellular matrix (ECM) enhancing homeostasis.

Language: Английский

Citations

0
Baicalin and kaempferol alleviates cuprizone-induced demyelination and microglial activation by inhibiting the STAT3 and NF-κB signaling pathways DOI
Liming Liu, Yufang Zhao,

Jingjing Bu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 154, P. 114592 - 114592

Published: April 3, 2025

Language: Английский

Citations

0
Development and Characterization of Folic Acid‐Decorated Fucoidan‐Poloxamer 407 Self‐Assembled Nanogels Co‐Loading Curcumin and Paclitaxel for Synergistically Enhanced Chemotherapeutic Efficacy DOI
Ngoc The Nguyen, Cuong Hung Luu,

Anh Quan Hoang

et al.

Journal of Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

ABSTRACT Cancer‐targeted nanomedicines demonstrate considerable potential in anticancer treatment due to their unique properties that improve therapeutic efficiency while minimizing off‐target effects. In this research, curcumin (Cur) and paclitaxel (PTX) were co‐loaded into dual‐targeting folate receptor/P‐selectin nanocarriers, which based on folate‐conjugated fucoidan‐poloxamer 407 copolymers (FA‐FP407), aiming inhibit breast cancer through intravenous administration. The successful synthesis of the self‐assembled nanogels was confirmed by analyzing chemical composition. resulting exhibited optimal physicochemical properties, including a negative surface charge, spherical morphology, hydrodynamic diameter 158.27 ± 3.15 nm, along with high drug‐loading efficiency. vitro drug release from significantly accelerated within tumor microenvironment at pH 5.5, it slowed down under physiological conditions. kinetics adhered Fickian diffusion model. Additionally, blank nanocarriers both hemocompatible cytocompatible, although they slight growth inhibition MCF‐7 cells. FA‐FP407@Cur@PTX demonstrated lower IC 50 compared free formulations single drug‐loaded cells, indicating could enhance activity co‐administering different drugs precisely accumulating cancerous site. This effect is attributed strong synergistic actions receptor‐mediated cellular uptake. study provides solid foundation for advancing targeted nanomedicine, facilitating co‐delivery multiple agents achieve superior effects chemotherapy.

Language: Английский

Citations

0
Research advances in the treatment of arthritis from natural products (2014-present) DOI
Ruilin Wang,

Chuandong Ji,

Jiayao Chen

et al.

Chinese Journal of Natural Medicines, Journal Year: 2025, Volume and Issue: 23(5), P. 529 - 540

Published: May 1, 2025

Language: Английский

Citations

0
Bioactive Compounds and Their Chondroprotective Effects for Osteoarthritis Amelioration: A Focus on Nanotherapeutic Strategies, Epigenetic Modifications, and Gut Microbiota DOI Open Access

Kota Sri Naga Hridayanka,

Asim K. Duttaroy, Sanjay Basak

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3587 - 3587

Published: Oct. 22, 2024

In degenerative joint disease like osteoarthritis (OA), bioactive compounds resveratrol, epigallocatechin gallate, curcumin, and other polyphenols often target various signalling pathways, including NFκB, TGFβ, Wnt/β-catenin by executing epigenetic-modifying activities. Epigenetic modulation can genes of pathophysiology via histone modification, promoter DNA methylation, non-coding RNA expression, some which are directly involved in OA but have been less explored. patients seek options that improve the quality their life addition to existing treatment with nonsteroidal anti-inflammatory drugs (NSAIDs). Although natural exhibit therapeutic potential against OA, several disadvantages loom, insolubility poor bioavailability. Nanoformulated promise a better way alleviate since they also control systemic events, metabolic, immunological, inflammatory responses, modulating host gut microbiota regulate pathogenesis. Recent data suggest dysbiosis OA. However, limited evidence is available on role as epigenetic modulators ameliorating Moreover, it not known whether effects polyphenolic microbial response mediated modulatory activities This narrative review highlights nanotherapeutic strategies utilizing compounds, reporting chondrocyte growth, metabolism, modifications amelioration.

Language: Английский

Citations

2