Mechanisms of Vitamins Inhibiting Ferroptosis DOI Creative Commons
Meng Zhang, Xin Chen,

Yumei Zhang

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1571 - 1571

Published: Dec. 20, 2024

Ferroptosis is an iron-dependent form of cell death, which characterized by the uncontrolled and overwhelming peroxidation membrane lipids. has been implicated in progression various pathologies, including steatotic liver, heart failure, neurodegenerative diseases, diabetes. Targeted inhibition ferroptosis provides a promising strategy to treat ferroptosis-related diseases. Multivitamins, vitamins A, B, C, D, E, K, have shown good ability inhibit ferroptosis. For example, vitamin A significantly upregulated expression several key ferroptotic gatekeepers genes through nuclear retinoic acid receptors X (RAR/RXR). Vitamin B6 could compensate for impaired glutathione (GSH) levels restore Glutathione peroxidase 4 (GPX4) cells, ultimately inhibiting D up-regulate anti-ferroptosis proteins activating receptors. E hydroquinone K (VKH2) can directly propagation lipid peroxidation, thereby In this review, we summarize currently understood mechanisms provide reference information future research on development inhibitors.

Language: Английский

Ferroptosis and hearing loss: from molecular mechanisms to therapeutic interventions DOI Creative Commons
Xiaozhen Lv,

Chenyi Yang,

Xianying Li

et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 40(1)

Published: Feb. 24, 2025

Hearing loss profoundly affects social engagement, mental health, cognition, and brain development, with sensorineural hearing (SNHL) being a major concern. Linked to ototoxic medications, ageing, noise exposure, SNHL presents significant treatment challenges, highlighting the need for effective prevention regeneration strategies. Ferroptosis, distinct form of cell death featuring iron-dependent lipid peroxidation, has garnered interest due its potential role in cancer, neuronal degeneration, especially loss. The emerging ferroptosis as crucial mediator suggests that it may offer novel therapeutic target otoprotection. This review aims summarise intricate connection between SNHL, offering fresh perspective exploring targeted strategies could potentially mitigate cochlear cells damage enhance quality life individuals impairments.

Language: Английский

Citations

1
The role of ferroptosis in neurodegenerative diseases DOI Creative Commons
Yifan Fei,

Yunjie Ding

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 15, 2024

Ferroptosis represents an iron − and lipid peroxidation (LPO)-mediated form of regulated cell death (RCD). Recent evidence strongly suggests the involvement ferroptosis in various neurodegenerative diseases (NDs), particularly Alzheimer’s disease (AD), Parkinson’s (PD), Huntington’s (HD), multiple sclerosis (MS), amyotrophic lateral (ALS), among others. The treatment poses both opportunities challenges context ND. This review provides a comprehensive overview characteristic features, induction inhibition ferroptosis, highlighting inhibitor underlying mechanisms responsible for its occurrence. Moreover, explores how these contribute to pathogenesis progression major disorders. Additionally, it presents novel insights into role ND summarizes recent advancements development therapeutic approaches targeting ferroptosis. These hold potential guide future strategies aimed at effectively managing debilitating medical conditions.

Language: Английский

Citations

6
Ferroptosis in the neurovascular unit after spinal cord injury DOI Creative Commons

Yushan Huang,

Jinzhu Bai

Experimental Neurology, Journal Year: 2024, Volume and Issue: 381, P. 114943 - 114943

Published: Sept. 4, 2024

Language: Английский

Citations

3
Natural products protect against spinal cord injury by inhibiting ferroptosis: a literature review DOI Creative Commons

Wei She,

Jian‐Qiang Su, Wenjian Ma

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 3, 2025

Spinal cord injury (SCI) is a severe traumatic condition that frequently results in various neurological disabilities, including significant sensory, motor, and autonomic dysfunctions. Ferroptosis, recently identified non-apoptotic form of cell death, characterized by the accumulation reactive oxygen species (ROS), intracellular iron overload, lipid peroxidation, ultimately culminating death. Recent studies have demonstrated ferroptosis plays critical role pathophysiology SCI, contributing significantly to neural demise. Three key cellular enzymatic antioxidants such as glutathione peroxidase 4 (GPX4), suppressor protein 1 (FSP1), dihydroorotate dehydrogenase (DHODH), been elucidated crucial components defense against ferroptosis. Natural products, which are bioactive compounds mostly derived from plants, garnered considerable attention for their potential therapeutic effects. Numerous reported several natural products can effectively mitigate death alleviate SCI symptoms. This review summarizes fifteen containing (-)-Epigallocatechin-3-gallate (EGCG), Proanthocyanidin, Carnosic acid, Astragaloside IV, Trehalose, 8-gingerol, Quercetin, Resveratrol, Albiflorin, Alpha-tocopherol, Celastrol, Hispolon, Dendrobium Nobile Polysaccharide, Silibinin, Tetramethylpyrazine shown promise treating inhibiting Additionally, this provides an overview mechanisms involved these proposes perspectives guide future research directions.

Language: Английский

Citations

0
Analyzing the role of ferroptosis in ribosome‐related bone marrow failure disorders: From pathophysiology to potential pharmacological exploitation DOI Creative Commons

Aliki Papadimitriou‐Tsantarliotou,

Chrysostomos Avgeros, Μαρία Κωνσταντινίδου

et al.

IUBMB Life, Journal Year: 2024, Volume and Issue: 76(12), P. 1011 - 1034

Published: July 25, 2024

Abstract Within the last decade, scientific community has witnessed importance of ferroptosis as a novel cascade molecular events leading to cellular decisions death distinct from apoptosis and other known forms cell death. Notably, such non‐ apoptotic iron‐dependent regulated been found be intricately linked several physiological processes well pathogenesis various diseases. To this end, recent data support notion that potential connection between inherited bone marrow failure (IBMF) in individuals with ribosomopathies may exist. In review, we suggest ribosome‐related IBMFs identified mutations ribosomal proteins lead changes ribosome composition hematopoietic progenitors, seem affect function, thus enhancing expression some mRNAs subgroups while reducing others. These an imbalance inside pathways are promoted others inhibited. This disturbance is accompanied by ROS production lipid peroxidation, additional finding most them iron accumulation. Once peroxidation accumulation two main characteristics ferroptosis, it possible mechanism plays key role manifestation IBMF type disease. If further confirmed, new pharmacological targets inhibitors already exploited for treatment diseases, could utilized improve ribosomopathies.

Language: Английский

Citations

1
Physiologic Regulation of Lipid Oxidation and Ferroptosis By Vitamin E, High-Density Lipoprotein, and Scavenger Receptor Class B Type 1 DOI Creative Commons
Jonathan S. Rink,

Andrea E. Calvert,

Alexandra Moxley

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

ABSTRACT Ferroptosis is a form of cell death caused by oxidative (-OOH) damage to phospholipids (PL) that comprise the membrane. Understanding mechanisms ferroptosis important because role it plays in human disease, including cancer and neurodegeneration. Previous work has focused on intracellular antioxidant enzyme glutathione peroxidase 4 (GPx4), which detoxifies PL-peroxides (PL-OOH) prevents ferroptosis. Studies also show alpha-tocopherol (α-toc), active Vitamin E, an exogenous lipophilic inhibits cells vitro neurons hematopoietic stem vivo. The α-toc engages manipulate PL redox balance are unknown. Lipoproteins, like high- low-density lipoproteins (HDL LDL), carry circulation, compelled our investigation their delivery Using neuronal models, here we lipoproteins, particularly HDL, deliver binding membrane receptor scavenger class B type 1 (SR-B1) prevent Additionally, synthesized SR-B1 targeted HDL-like particles contained validate data obtained with native lipoproteins. We reveal tunable cellular axis whereby synthetic HDLs containing target reduce PL-OOH

Language: Английский

Citations

1
Mechanisms of Vitamins Inhibiting Ferroptosis DOI Creative Commons
Meng Zhang, Xin Chen,

Yumei Zhang

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1571 - 1571

Published: Dec. 20, 2024

Ferroptosis is an iron-dependent form of cell death, which characterized by the uncontrolled and overwhelming peroxidation membrane lipids. has been implicated in progression various pathologies, including steatotic liver, heart failure, neurodegenerative diseases, diabetes. Targeted inhibition ferroptosis provides a promising strategy to treat ferroptosis-related diseases. Multivitamins, vitamins A, B, C, D, E, K, have shown good ability inhibit ferroptosis. For example, vitamin A significantly upregulated expression several key ferroptotic gatekeepers genes through nuclear retinoic acid receptors X (RAR/RXR). Vitamin B6 could compensate for impaired glutathione (GSH) levels restore Glutathione peroxidase 4 (GPX4) cells, ultimately inhibiting D up-regulate anti-ferroptosis proteins activating receptors. E hydroquinone K (VKH2) can directly propagation lipid peroxidation, thereby In this review, we summarize currently understood mechanisms provide reference information future research on development inhibitors.

Language: Английский

Citations

1