Identification of Penexanthone A as a Novel Chemosensitizer to Induce Ferroptosis by Targeting Nrf2 in Human Colorectal Cancer Cells

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(8), P. 357 - 357

Published: Aug. 6, 2024

Ferroptosis has emerged as a potential mechanism for enhancing the efficacy of chemotherapy in cancer treatment. By suppressing nuclear factor erythroid 2-related 2 (Nrf2), cells may lose their ability to counteract oxidative stress induced by chemotherapy, thereby becoming more susceptible ferroptosis. In this study, we investigate penexanthone A (PXA), xanthone dimer component derived from endophytic fungus

Language: Английский

---

Xanthone Dimers in Angiosperms, Fungi, Lichens: Comprehensive Review of Their Sources, Structures, and Pharmacological Properties

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 967 - 967

Published: Feb. 19, 2025

Xanthone dimers, a distinctive class of natural metabolites renowned for their unique structures, are abundantly present in diverse array angiosperms, fungi, and lichens. These compounds not only exhibit remarkable diversity but also possess broad spectrum biological activities. In this comprehensive review spanning from 1966 to 2024, we synthesized the relevant literature delve into occurrence, potency, molecular structure chemical xanthone dimers. The aim is serve as an insightful reference point future scientific inquiries dimers potential applications.

Language: Английский

---

5,6-Dihydro-5,6-Epoxymultiplolide A, Cytosporone C, and Uridine Production by Diaporthe hongkongensis, an Endophytic Fungus from Minquartia guianensis

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 792 - 792

Published: March 31, 2025

Endophytic fungi are valuable sources of bioactive secondary metabolites, with potential applications in pharmaceutical and agricultural fields. This study investigates the metabolic Diaporthe hongkongensis, an endophytic fungus isolated from Minquartia guianensis. To date, no metabolites have been identified this species, highlighting novelty research its contribution to understanding chemical diversity fungi. The was cultivated on parboiled rice under static dark conditions for 28 days, leading isolation following three compounds: 5,6-dihydro-5,6-epoxymultiplolide A (1), cytosporone C (2), uridine (3). Structural identification carried out using nuclear magnetic resonance (NMR) spectroscopy mass spectrometry. results revealed versatility D. as demonstrated by ability produce structurally diverse substances biological relevance. Hence, it describes first marking a significant step profile. known antifungal compound lactone derivative underscores biosynthetic fungus, while nucleoside expands repertoire fungal suggesting possible roles cellular metabolism stress adaptation. These findings highlight role prolific potentially natural products, supporting further exploration their biotechnological applications.

Language: Английский

---

Identification of ferroptosis-related gene signatures in temporal lobe epilepsy with hippocampal sclerosis

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 2, 2025

Ferroptosis is a form of regulated cell death that damages neurons in the central nervous system. In this study, we aimed to construct ferroptosis-related gene signatures temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and explore their diagnostic role TLE-HS. The GSE205661 dataset was acquired for training purposes, while GSE71058 obtained serve as validation dataset. Subsequently, differentially expressed genes (FR-DEGs) TLE-HS were further analyzed. We used weighed co-expression network analysis (WGCNA) algorithm, single-factor logistic regression analysis, LASSO algorithm screen characteristic FR-DEGs. Then, receiver operating (ROC) evaluate value these disease diagnosis. Finally, long non-coding RNA (lncRNA)-microRNA (miRNA)-messenger (mRNA) constructed. identified 141 FR-DEGs TLE-HS, enriched T-cell activation involved immune response signaling pathways related lipids atherosclerosis. Further WGCNA performed select 47 overlapping FR-DEGs, which significantly 13 biological processes 14 Kyoto Encyclopedia Genes Genomes (KEGG) pathways, including negative regulation apoptotic process ferroptosis. Four genes, namely PDK4, SMPD1, GPT2, METTL14, signature Moreover, ROC derived from four predicting had an area under curve (AUC) 0.988 0.929, respectively. Furthermore, lncRNA-miRNA-mRNA constructed 4 consisted 5 lncRNAs miRNAs. based on found be strong predictor they may represent valuable therapeutic targets

Language: Английский

---

Polyketide production in a mangrove-associated fungus Diaporthe goulteri , induced by chemical epigenetic modification

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Dec. 23, 2024

Studies on the chemical composition of endophytic fungus Diaporthe goulteri, isolated from Acanthus ilicifolius L., by using epigenetic modification to activate clusters biosynthetic genes that are silenced or poorly expressed in fungi, resulting obtainment ten polyketides. Among these compounds were six new compounds, including cytosporin E2 (1), D1 (2), G1 (3), J1 (4), K1 (5), F1 (6), and four known E (7), Y3 (8), D (9), L (10). The structures established comprehensive spectroscopic analysis, quantum-chemical calculations, modified Mosher's method. cytotoxic, antioxidant anti-inflammatory activities evaluated.

Language: Английский

---

Using metabolomics to explore the effects of epigenetic-modification strategies on the metabolites of <italic>Acanthus ilicifolius</italic> L. endophytic fungi against ovarian cancer

Chinese Journal of Chromatography, Journal Year: 2024, Volume and Issue: 42(11), P. 1015 - 1023

Published: Oct. 31, 2024

Ovarian cancer is a serious threat to women's health and safety. So far, people have discovered more than 130 small molecule compounds of natural origin for anti-tumor, which approximately 50% are microbial origin. The

Language: Английский

---