Mitochondrion, Journal Year: 2024, Volume and Issue: 80, P. 101977 - 101977
Published: Nov. 4, 2024
Language: Английский
Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 2975 - 2975
Published: Aug. 27, 2024
Malignant gliomas present great difficulties in treatment, with little change over the past 30 years median survival time of 15 months. Current treatment options include surgery, radiotherapy (RT), and chemotherapy. New therapies aimed at suppressing formation new vasculature (antiangiogenic treatments) or destroying formed tumor (vascular disrupting agents) show promise. This study summarizes existing knowledge regarding processes by which glioblastoma (GBM) tumors acquire resistance to antiangiogenic treatments. The discussion encompasses activation redundant proangiogenic pathways, heightened cell invasion metastasis, induced hypoxia, creation vascular mimicry channels, regulation immune microenvironment. Subsequently, we explore potential strategies overcome this resistance, such as combining other methods, personalizing treatments for each patient, focusing on therapeutic targets, incorporating immunotherapy, utilizing drug delivery systems based nanoparticles. Additionally, would like discuss limitations methods future directions enhance beneficial effects patients GBM. Therefore, review aims research outcome GBM provide a more promising opportunity thoroughly exploring mechanisms investigating novel strategies.
Language: Английский
Citations
10
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 5, 2024
Adjuvant therapy is essential in cancer treatment to enhance primary effectiveness, reduce adverse effects, and prevent recurrence. Small molecule inhibitors as adjuvants immunotherapy aim harness their immunomodulatory properties optimize outcomes. By modulating the tumor microenvironment, enhancing immune cell function, increasing sensitivity immunotherapy, small have potential improve patient responses. This review discusses evolving use of treatment, highlighting role efficacy opportunities for advancing therapies future.
Language: Английский
Citations
5
Pharmacognosy Magazine, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
Background Activation of PRR11 contributes to the progression lung cancer and is related its methylation status. However, regulatory mechanism luteolin-zinc (Lu-Zn) on methylation-mediated under hypoxic conditions remains be explored.. Purpose This study aims investigate inhibitory effect Lu-Zn cells, regulation ferroptosis, role in hypoxia. Methods In vitro experiments were conducted evaluate focusing impact invasion, migration, ferroptosis. The expression levels PRR11, status, microRNA-6769b-3p (miR-6769b-3p) also analyzed. Results Under conditions, significantly inhibited invasion migration abilities cells promoted Additionally, reversed pro-cancer effects induced by PRR11. At molecular level, regulated miR-6769b-3p. Conclusion Our demonstrates that enhances reduces through leads inhibition downstream PI3K/AKT/mTOR signaling pathway, promoting ferroptosis exerting anti-lung effects.
Language: Английский
Citations
0
Talanta, Journal Year: 2025, Volume and Issue: 289, P. 127750 - 127750
Published: Feb. 14, 2025
Language: Английский
Citations
0
Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120215 - 120215
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 1, 2025
Esophageal squamous cell carcinoma (ESCC) is a serious invasive malignancy with an ambiguous etiology. Evidence indicates that circular RNA (circRNA) significantly involved in the regulatory processes associated cancer development. Nevertheless, specific molecular mechanisms through which circRNA facilitates progression of ESCC are still largely undefined. Here, we identified expression hsa_circ_0007580 (designated circPRKCA) was markedly elevated ESCC. Fluorescence situ hybridization (FISH) conducted to verify expression, intracellular localization, and potential prognostic value circPRKCA based on tissue microarray. Gain- loss-of-function assays were employed investigate effects both vitro vivo. pull-down mass spectrometry (MS) performed identify proteins bound circPRKCA. mRNA sequencing screen downstream target genes Furthermore, immunoprecipitation methylated (MeRIP) analysis used explore mechanisms. We found exhibited significant upregulation tissues correlated unfavorable outcomes. Biological function experiments further confirmed enhances capabilities migration, invasion, angiogenesis Mechanistically, engages interaction Y-box binding protein 1 (YBX1) within cytoplasmic milieu, consequently preventing ubiquitination-mediated degradation YBX1. Increased concentrations YBX1 increase stability granulocyte–macrophage colony-stimulating factor (CSF2) 5-methylcytosine (m5C)-dependent manner. This process metastasis In this research, correlation between prognoses patients It instrumental metastatic via YBX1/CSF2 signaling pathway. Consequently, targeting may represent promising therapeutic strategy for
Language: Английский
Citations
0
Medical Hypotheses, Journal Year: 2025, Volume and Issue: unknown, P. 111624 - 111624
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140392 - 140392
Published: Oct. 1, 2024
Language: Английский
Citations
2
Microfluidics and Nanofluidics, Journal Year: 2024, Volume and Issue: 28(10)
Published: Sept. 30, 2024
Language: Английский
Citations
1
Mitochondrion, Journal Year: 2024, Volume and Issue: 80, P. 101977 - 101977
Published: Nov. 4, 2024
Language: Английский
Citations
0