A Machine Learning Approach to Evaluating the Impact of Natural Oils on Alzheimer’s Disease Progression DOI Creative Commons
Rema M. Amawi, Khalil Al-Hussaeni,

Joyce James Keeriath

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(15), P. 6395 - 6395

Published: July 23, 2024

Alzheimer’s Disease is among the major chronic neurodegenerative diseases that affects more than 50 million people worldwide. This disease irreversibly destroys memory, cognition, and overall daily activities which occur mainly elderly. Few drugs are approved for management despite its high prevalence. To date, available in market cannot reverse damage of neurons caused by leading to exacerbation symptoms possibly death. Medicinal plants considered a rich source chemical constituents have been contributing modern drug discovery many therapeutic areas including cancer, infectious, cardiovascular, Central Nervous System (CNS) diseases. Moreover, essential oils extracted from plant organs reported wide array biological activities, their roles as antioxidants, antiaging, cytotoxic, anti-inflammatory, antimicrobial, enzyme inhibitory activities. article highlights promising potential plants’ novel options halting progression. In this article, 428 compounds were isolated 21 plants. A comparative study carried out employing variety machine learning techniques, validation, evaluation metrics, predict oils’ efficacy against Extensive experiments on oil data suggest prediction accuracy up 82% can be achieved given proper preprocessing, feature selection, model configuration steps. underscores integrating with natural product research prioritize expedite identification bioactive could lead effective interventions Disease. Further exploration optimization techniques provide robust platform development, facilitating faster efficient screening treatments.

Language: Английский

The Antioxidant Role of Aromatic Plant Extracts in Managing Neurodegenerative Diseases: A Comprehensive Review DOI Creative Commons

Youyang Zhu,

Miao Tian, Shiyu Lu

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111253 - 111253

Published: Feb. 1, 2025

Neurodegenerative diseases (NDDs) are a class of cognitive and motor disorders including Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), Amyotrophic Lateral Sclerosis (ALS), others. They caused by lesions in cells tissues the central nervous system, resulting corresponding dysfunctions consequent decline functions. Neural extremely vulnerable to oxidative stress, which plays critical biological roles NDDs. Aromatic compounds found extensively natural plants have substantial effects anti-oxidative stress damage, not only wide range research applications cosmetics, foods, etc., but also frequently utilized treatment various system diseases. This review summarizes relevant mechanisms NDDs (AD, PD, HD, ALS) reviews aromatic such as polyphenols, terpenoids, flavonoids that can be used management neurodegenerative diseases, well their specific antioxidant action. will serve reference for future experimental studies on illnesses while offering fresh insights into clinical therapy.

Language: Английский

Citations

0
Preparation of Multicomponent Fisetin‐Hydroxypropyl β Cyclodextrin‐Poloxamer Inclusion Complex by Microwave Technology DOI Open Access
Abdul Ahad, Mohammad Raish, Yousef A. Bin Jardan

et al.

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(3)

Published: March 1, 2025

ABSTRACT Fisetin (FS) is a polyphenolic flavonoid possessing multiple biological activities along with broad nutraceutical applications. The low solubility of FS greatly limits its bioavailability and use. aim the study was to prepare an ternary inclusion complex (TIC) using hydroxypropyl β‐cyclodextrin (HPβCD) Poloxamer 188 (P188) by microwave technology. Phase studies were performed in presence HPβCD (1 10 mM) P188. vitro release FS, physical mixture (TPM) FS‐TIC determined. Additionally, DSC, FTIR, XRD, SEM on TPM, characterize samples. Furthermore, pure assessed for their antioxidant activity. outcomes phase revealed that 6.33‐fold boosted HPβCD/P188. TPM demonstrated drug 34.09% 62.29%, respectively. While maximum 84.45% obtained FS‐TIC; this could be due formation water‐soluble complex. Results showed from TIC occurred through Fickian diffusion mechanism followed Higuchi pattern. analyses verified interaction subsequently supported formation. developed superior activity compared FS. It concluded prepared technique as carrier provides potential approach facilitate release. In addition, techniques combined cyclodextrin/polymer properties present intriguing circumventing issue poorly soluble compounds like fisetin.

Language: Английский

Citations

0
Natural compounds as therapeutic candidates for spinocerebellar ataxia type 1: a computational approach DOI
Surbhi Singh,

Suchitra Singh,

Deepika Joshi

et al.

In Silico Pharmacology, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 15, 2025

Language: Английский

Citations

0
The comprehensive review of eucalyptol: synthesis, metabolism, and therapeutic applications in disease treatment DOI

Bin Yao,

Bin He, Jiahua Peng

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: March 28, 2025

Language: Английский

Citations

0
Anti-atherosclerotic effect of lipid/cholesterol-cyclodextrin inclusion complexes similar to free cyclodextrins in ApoE-/- mice fed a high-fat diet DOI Creative Commons
Yuanfang Li, Yuan Zhang, Meng-Fei Lan

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100811 - 100811

Published: April 1, 2025

Language: Английский

Citations

0
Variation in the essential oil composition of wild Artemisia haussknechtii Boiss. populations collected from Iran DOI
Milad Javanmard,

H Naghdi Badi,

Ali Mohammadi ‎Torkashvand

et al.

Genetic Resources and Crop Evolution, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Language: Английский

Citations

1
A Machine Learning Approach to Evaluating the Impact of Natural Oils on Alzheimer’s Disease Progression DOI Creative Commons
Rema M. Amawi, Khalil Al-Hussaeni,

Joyce James Keeriath

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(15), P. 6395 - 6395

Published: July 23, 2024

Alzheimer’s Disease is among the major chronic neurodegenerative diseases that affects more than 50 million people worldwide. This disease irreversibly destroys memory, cognition, and overall daily activities which occur mainly elderly. Few drugs are approved for management despite its high prevalence. To date, available in market cannot reverse damage of neurons caused by leading to exacerbation symptoms possibly death. Medicinal plants considered a rich source chemical constituents have been contributing modern drug discovery many therapeutic areas including cancer, infectious, cardiovascular, Central Nervous System (CNS) diseases. Moreover, essential oils extracted from plant organs reported wide array biological activities, their roles as antioxidants, antiaging, cytotoxic, anti-inflammatory, antimicrobial, enzyme inhibitory activities. article highlights promising potential plants’ novel options halting progression. In this article, 428 compounds were isolated 21 plants. A comparative study carried out employing variety machine learning techniques, validation, evaluation metrics, predict oils’ efficacy against Extensive experiments on oil data suggest prediction accuracy up 82% can be achieved given proper preprocessing, feature selection, model configuration steps. underscores integrating with natural product research prioritize expedite identification bioactive could lead effective interventions Disease. Further exploration optimization techniques provide robust platform development, facilitating faster efficient screening treatments.

Language: Английский

Citations

0