Therapeutic Effects of Lavender Oil on Streptozotocin-Induced Diabetes Mellitus and Experimental Thrombosis

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 166 - 166

Published: Jan. 30, 2025

Diabetes mellitus is a metabolic disorder associated with oxidative stress, inflammation, and coagulation disturbances, which contribute to microvascular macrovascular complications. We evaluated the therapeutic effects of lavender oil (Lavandula angustifolia) in streptozotocin (STZ)-induced rat model type 1 diabetes (T1DM) experimentally induced thrombosis. Sixty male Wistar rats were divided into control, thrombosis, diabetes, thrombosis–diabetes, pretreatment groups (100 200 mg/kg body weight [bw]). Lavender exhibited dose-dependent benefits, bw dose leading significant reductions proinflammatory cytokines (e.g., tumor necrosis factor α (TNF-α); regulated upon activation, normal T cell expressed secreted (RANTES); monocyte chemoattractant protein-1 (MCP-1)) along improved glycemic partial restoration C-peptide levels, attenuation matrix metalloproteinase 2 9 (MMP-2 MMP-9) activity (p < 0.0001). Histopathological analyses confirmed its organ-protective antithrombotic effects, including reduced tissue damage, vascular thrombus formation, prolonged bleeding clotting times. Our findings suggest that exhibits antioxidant, anti-inflammatory, hypoglycemic, indicating potential as complementary therapy for managing inflammation T1DM or without

Language: Английский

Advances in plant essential oils and drug delivery systems for skincare

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

Essential oils, often referred to as "liquid gold," are renowned for their broad biological activity. Ancient Egyptians used essential oils' antibacterial and antiseptic effects preserve mummies, ancient Greeks olive oil sun protection, Chinese oils treat wounds. When applied the facial skin, potent anti-inflammatory, antioxidant, pharmacological characteristics provide various benefits, including sunscreen, skin-whitening, anti-aging effects. This paper aims summarize application of plant in skin whitening, antioxidant recent years, deeply analyzes internal relationship between modern drug delivery system, expounds how overcome limitations through specific enhance its activity stability, realize sustained release reduce potential toxicity, also discusses positive on brain function olfactory pathway, emphasizes possible safety risks use oil, puts forward corresponding suggestions use. Using keywords such "essential oils," "antioxidant," "anti-tyrosinase," Antibacterial Effects anti-inflammatory," "anti-anxiety," "drug carrier systems," a comprehensive search was conducted PubMed, CNKI, Baidu, Wanfang databases articles from past 5 years. Further screening performed select studies demonstrating efficacy topical or external application. Various showed strong oxidants, agents, anti-inflammatory skin-whitening agents. Combined with new it not only enhances but reduces inherent defects volatility, irritation, has targeted effect. At same time, integration into care products can make dual functions smell epidermal system nourish repair maximize oil. review delves systems, advocating broader natural resources technology. By strategically utilizing we promote sustainable development global economy. However, extensive clinical trials still required evaluate effectiveness systems.

Language: Английский

New insights into individual differences in response to chronic unpredictable mild stress (CUMS) in rats with respect to hippocampal BDNF and GSK3-β expression levels

Physiology & Behavior, Journal Year: 2024, Volume and Issue: unknown, P. 114718 - 114718

Published: Oct. 1, 2024

Language: Английский