Piezo1 is a Pathogenic Gene and Therapeutic Target for Neurological Diseases

International Journal of Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23

Published: April 25, 2025

Piezo1 is a ubiquitously expressed non-selective cation channel protein found across various species. It possesses the ability to detect and respond external mechanical forces, converting cues into intracellular bioelectrical events, thereby facilitating propagation of electrochemical signals. Within nervous system, integral synaptogenesis myelination, modulation pro-inflammatory mediators, neuropathic pain, cognitive processes, angiogenesis, regulation cerebral hemodynamics, consequently impacting pathogenesis progression neurological disorders. This review meticulously summarizes synthesizes existing literature provide an exhaustive overview Piezo1's roles mechanisms in spectrum diseases, including neurodegenerative disorders, cerebrovascular accidents, traumatic brain injuries, gliomas, multiple sclerosis, epilepsy. Additionally, it explores potential therapeutic applications targeting Piezo1. The discussion also encompasses current research limitations, imperative need for future investigations, prospective strategies. Our analysis indicates that susceptibility gene conditions, its expression inhibition may confer benefits. In summary, this comprehensive offers novel insights involvement diseases establishes theoretical groundwork development Piezo1-targeted interventions.

Language: Английский

S100A8 knockdown activates the PI3K/AKT signaling pathway to inhibit microglial autophagy and improve cognitive impairment mediated by chronic sleep deprivation

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113375 - 113375

Published: Oct. 16, 2024

Cognitive dysfunction is one of the major symptoms chronic sleep deprivation (CSD). Abnormal autophagy and apoptosis are thought to be important mechanisms. S100 Calcium Binding Protein A8 (S100A8) plays a key role in microglia. This study investigated whether S100A8 knockdown can effectively inhibit aberrant microglia improve cognitive function by activating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway under CSD conditions.

Language: Английский