Natural Compounds for the Treatment of Acute Pancreatitis: Novel Anti-Inflammatory Therapies

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1101 - 1101

Published: Sept. 2, 2024

Acute pancreatitis remains a serious public health problem, and the burden of acute is increasing. With significant morbidity complications, appropriate effective therapies are critical. Great progress has been made in understanding pathophysiology over past two decades. However, specific drugs targeting key molecules pathways involved still require further study. Natural compounds extracted from plants have variety biological activities can inhibit inflammation oxidative stress by blocking several signaling pathways, such as nuclear factor kappa-B mitogen-activated protein kinase pathways. In this article, we review therapeutic effects various types phytochemicals on discuss mechanism action these natural pancreatitis, aiming to provide clearer insights into treatment pancreatitis.

Language: Английский

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Dioscin exerts nephroprotective effects by attenuating oxidative stress and necroptosis-induced inflammation

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 140, P. 112885 - 112885

Published: Aug. 7, 2024

Language: Английский

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Therapeutic Significance of NLRP3 Inflammasome in Cancer: Friend or Foe?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13689 - 13689

Published: Dec. 21, 2024

Besides various infectious and inflammatory complications, recent studies also indicated the significance of NLRP3 inflammasome in cancer progression therapy. NLRP3-mediated immune response pyroptosis could be helpful or harmful cancer, depend on nature tumor microenvironment. The activation increase surveillance efficacy immunotherapy. It can lead to removal cells by recruitment phagocytic macrophages, T-lymphocytes, other site. On hand, harmful, as chronic inflammation driven supports creating an environment that facilitates cell proliferation, migration, invasion, metastasis. release pro-inflammatory cytokines such IL-1β IL-18 promote growth angiogenesis, while sustained may suppression, hindering effective anti-tumor responses. In this review article, we discuss role inflammasome-mediated pathophysiology types; understanding is essential for development innovative therapeutic strategies spread.

Language: Английский

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Therapeutic effects of resveratrol and β-carotene on L-arginine-induced acute pancreatitis through oxidative stress and inflammatory pathways in rats

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 30, 2024

Language: Английский

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