npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)
Published: Dec. 19, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2678 - 2678
Published: March 16, 2025
Despite the substantial advances in cancer therapies, developing safe and effective treatment methodologies is critical. Natural (plant-derived compounds), such as flavonoids, might be crucial a methodology without toxicity toward healthy tissues. Prunin flavonoid with potential to used biomedical applications. has yet undergo thorough scientific research, its precise molecular mechanisms of action remain largely unexplored. This review summarizes therapeutic prunin for first time, focusing on underlying an anticancer compound. gained significant attention due antioxidant, anti-inflammatory, effects. aims unlock how functions at level exert effects, primarily modulating key cellular pathways. Furthermore, we have discussed prunin’s adjunctive therapy conventional treatments, highlighting ability strengthen responses while decreasing drug resistance. Moreover, discussion probes into innovative delivery methods, particularly nanoformulations, that address bioavailability, solubility, stability limitations optimize application. By providing comprehensive analysis properties, this stimulate further exploration using agent, thereby progressing development targeted, selective, safe, methods.
Language: Английский
Citations
1
Plants, Journal Year: 2025, Volume and Issue: 14(5), P. 777 - 777
Published: March 3, 2025
Geranium diffusum Kunth is a medicinal plant native to Ecuadorian highlands with limited scientific study despite its ethnopharmacological relevance. The present investigates the phytochemical properties and cytotoxic effects of methanolic extract G. diffusum. Comprehensive analyses revealed rich composition bioactive compounds, predominantly flavonoids rutin, isoquercetin, isorhamnetin-3-glucoside, known for their therapeutic potential, were isolated. solvent fractions evaluated activity against three cell lines: RKO, SW613-B3, HCT-116. Notably, ethyl acetate fraction exhibited cytotoxicity an IC50 value 44.47 ± 1.02 μg/mL SW613-B3 line, indicating significant anticancer activity. dichloromethane also demonstrated noteworthy on RKO HCT-116 lines, while higher viability in cells. No genotoxicity was found CHO-K1 These findings underscore potential as valuable source compounds developing agents cancer highlight need further research into pharmacokinetics, vivo efficacy, synergistic flavonoid constituents. This contributes enhancing our understanding underexplored plants supports conservation efforts biodiversity.
Language: Английский
Citations
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Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 494 - 494
Published: March 28, 2025
Background/Objectives: Multidrug resistance is one the leading problems in cancer treatment, where overexpression of P-gp and other drug efflux pumps regarded as primary cause. With intention to develop transporter inhibitors, natural products such phenolics have shown great potential diverse attention recently. Among these, isorhamnetin (ISO), an O-methylated flavonol, predominantly found fruits leaves various plants. Thus, this study aimed investigate effects ISO on mRNA expression membrane transporters P-gp, BCRP, MRP 1, 2, 5, protein well GSTP1 GSH content DLD1 HCT-116 colon cells. Methods: The cytotoxic effect assessed using MTT test, while qPCR immunocytochemistry methods were used determine gene levels. concentration reduced glutathione was determined colorimetric method. Results: Based results, can modulate responsible for development (all transcriptional level downregulated cells, only MRP1 both investigated cell lines). Increased treated cells suggest metabolizing ejection with GSH-dependent pumps. Conclusions: future experiments, a medicinal compound could be chemosensitizer prevent or overcome transporter-mediated resistance.
Language: Английский
Citations
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Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: April 5, 2025
Cholangiocarcinoma (CCA), which is a malignant tumor originating from the epithelial cells of bile ducts, has witnessed an increasing incidence year by year. Owing to dearth effective treatments, prognosis for CCA rather poor. Isorhamnetin known possess anti-tumor, anti-inflammatory and oxidative stress modulating effects; however, its role in remains unclear. Firstly, we screened core targets pathways isorhamnetin treatment through network pharmacology approach. Subsequently, verified via molecular docking that could dock stably with isorhamnetin. Finally, inhibitory effect on biological behavior vitro vivo experiments. Based analysis, came conclusion AKT1 might be target CCA. Molecular indicated was capable binding In experiments demonstrated able suppress proliferation metastasis cells, played pivotal this process. Mechanistically speaking, exerts growth PI3K/AKT signaling pathway. Our study first time can inhibit progression PI3K/AKT, may
Language: Английский
Citations
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Molecules, Journal Year: 2025, Volume and Issue: 30(10), P. 2231 - 2231
Published: May 21, 2025
This study investigated the correlation between thirteen inorganic elements, five key bioactive compounds, and environmental factors in Polygonum perfoliatum L. from fifteen different origins. Analyses were conducted using techniques such as ultrasound-assisted extraction, HPLC, ICP-AES, PCA, HCA. The results indicate that geographical origin significantly influences contents of elements compounds L., a certain exists among factors. research provides theoretical foundation for development utilization
Language: Английский
Citations
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Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: May 26, 2025
Cancer is a significant public health problem worldwide, and its morbidity mortality are challenging to improve, which an important obstacle prolonging life expectancy. Cytotoxic drugs have been used in anti-cancer therapy since the 1940s. They play role tumor therapy. However, drug resistance systemic toxicity often limit application. Combination or synergistic chemotherapy can promote therapeutic effects reduce toxicity. Quercetin (QUE) natural flavonoid widely found fruits vegetables. It has anti-cancer, anti-inflammatory, antioxidant, neuroprotective properties. An increasing number of studies that combination QUE chemosensitization effect. To certain extent, it inhibit side chemotherapeutic drugs, such as nephrotoxicity, cardiotoxicity, reproductive toxicity, neurotoxicity, attracted great attention. The immune system plays development. Notably, several revealed immunomodulatory by promoting differentiation cells inhibiting checkpoint expression. In conclusion, current emphasized potential chemosensitization, reduction toxic effects, enhancement response. more preclinical clinical cohort needed determine QUE’s efficacy, mechanism, optimal formulation, long-term effects.
Language: Английский
Citations
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Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 5, 2025
Language: Английский
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In Silico Pharmacology, Journal Year: 2025, Volume and Issue: 13(2)
Published: April 16, 2025
Language: Английский
Citations
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Journal of King Saud University - Science, Journal Year: 2024, Volume and Issue: 36(11), P. 103582 - 103582
Published: Dec. 1, 2024
Language: Английский
Citations
0
npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)
Published: Dec. 19, 2024
Language: Английский
Citations
0