Lactate Dehydrogenase A Is a Novel Positive Regulator of Vascular Smooth Muscle Cell Ferroptosis During Aortic Dissection DOI
Feng Xin, Xin Yi, Bo Huo

et al.

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Vascular smooth muscle cell (VSMC) ferroptosis is a pivotal event in the process of aortic dissection (AD), and number agents have protective role against AD by inhibiting VSMC ferroptosis. While glycolysis an ancient pathway related to almost all biological processes, its precise involvement remains unclear.

Language: Английский

Efficient antiviral activity of a novel magnolol derivative against aquatic rhabdoviruses DOI

Fei Yang,

Zhiqiang Zhang,

Shenye Qu

et al.

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742464 - 742464

Published: March 1, 2025

Language: Английский

Citations

0
Inhibition of Bovine Enterovirus Infection by Magnolol via Modulating the Gut Microbiota in Mice DOI Creative Commons

Junying Hu,

Qun Zhang, Dan Liu

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(6), P. 750 - 750

Published: May 24, 2025

Bovine enterovirus (BEV) infection is one of the important infectious diseases that cause digestive and respiratory symptoms in cattle, posing a significant threat to cattle industry. Currently, no vaccines or therapeutic drugs are available for this disease. In our study, we utilized mouse model investigate effects BEV on gut microbiota examine potential magnolol (Mag), polyphenolic bioactive substance, terms infection. significantly altered composition, where abundance some beneficial bacteria, such as Lactobacillaceae Lactobacillus, was markedly reduced. Mag effectively inhibited vivo. Upon infection, treatment reduced α-diversity microbiota, with statistically differences day 3 post-infection compared Mag-untreated group. More interestingly, reversed effect Lactobacillus abundance, indicating positively regulates bacteria. The fecal transplantation (FMT) experiment demonstrated feces from Mag-treated mice decreased virus loads small intestine samples BEV-infected mice. These findings demonstrate interaction between highlight regulatory role Mag’s anti-BEV effects, opening up new avenue preventing controlling via targeted modulation microbiota.

Language: Английский

Citations

0
Critical Role of Ferroptosis in Viral Infection and Host Responses DOI
Qian Mao,

Qin Luo,

Shumei Ma

et al.

Virology, Journal Year: 2025, Volume and Issue: 606, P. 110485 - 110485

Published: March 8, 2025

Language: Английский

Citations

0
Therapeutic potential of Da Cheng Qi Decoction and its ingredients in regulating ferroptosis via the NOX2-GPX4 signaling pathway to alleviate and predict severe acute pancreatitis DOI
Jian Chen,

Fu Li,

Wenlong Luo

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111733 - 111733

Published: March 1, 2025

Language: Английский

Citations

0
Lactate Dehydrogenase A Is a Novel Positive Regulator of Vascular Smooth Muscle Cell Ferroptosis During Aortic Dissection DOI
Feng Xin, Xin Yi, Bo Huo

et al.

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Vascular smooth muscle cell (VSMC) ferroptosis is a pivotal event in the process of aortic dissection (AD), and number agents have protective role against AD by inhibiting VSMC ferroptosis. While glycolysis an ancient pathway related to almost all biological processes, its precise involvement remains unclear.

Language: Английский

Citations

0