Research Progress of Flavonoids in Spinal Cord Injury: Therapeutic Mechanisms and Drug Delivery Strategies

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Spinal cord injury (SCI) is a serious neurological disease with an extremely high disability rate. Most patients show loss of motor and sensory functions below the level injury. Current treatment protocols are based on early surgical decompression pharmacotherapy. However, efficacy these interventions suboptimal. Due to its complex pathophysiological mechanisms difficulty central nervous system (CNS) regeneration, exploring effective therapeutic remains daunting. Flavonoids secondary metabolites unique plants that have attracted attention in recent years for their potential now commonly used inflammation, tumors, other diseases. For SCI, related studies still exploring; some compounds, such as quercetin, fisetin, hesperetin, shown good anti-inflammatory anti-apoptotic properties, which help restore function injured spinal cord. flavonoids exhibit certain disadvantages, including poor solubility, low bioavailability, inability achieve long-term controlled release. Some proposed drug delivery strategies-including nanoparticles, hydrogels, collagen scaffolds-to enhance efficacy. In this paper, we summarize strategies SCI by searching relevant literature propose future research directions provide new ideas multimodal SCI.

Language: Английский

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Electroacupuncture promotes functional recovery after spinal cord injury in rats by regulating P2X4R/p38 MAPK signaling pathway and suppressing inflammatory responses

Neuroreport, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

This study aimed to investigate whether electroacupuncture can modulate the purinergic P2X4 receptor (P2X4R)/p38 mitogen-activated protein kinase (MAPK) pathway, thereby reducing inflammatory responses and facilitating functional recovery in a rat model of spinal cord injury (SCI). The SCI was developed female rats. intervention began on seventh day after modeling, mainly Jiaji, Dazhui, Mingmen. Sensory function evaluated via mechanical withdrawal threshold (MWT) thermal latency (TWL), while motor measured using Basso, Beattie, Bresnahan (BBB) scoring system footprint analysis. To analyze expression related P2X4R/p38 MAPK signaling pathways, methods such as immunohistochemistry, immunofluorescence analysis, quantitative real-time PCR, western blotting were utilized. evaluate levels cytokines, ELISAs Additionally, hematoxylin eosin staining, histological alterations tissue investigated. results showed that MWT, TWL, BBB scores decreased, P2X4R, phosphorylated-p38 MAPK, phosphorylated nuclear factor κB p65 increased, tumor necrosis factor-α, interleukin (IL)-1β, IL-6 elevated, histopathological damage more pronounced SCI. However, treatment effectively reversed these pathological changes. We demonstrate alleviate rats by inhibiting activation pathway response.

Language: Английский

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Nitric oxide synthases: A delicate dance between bone regeneration and neuronal birth

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118105 - 118105

Published: April 27, 2025

Language: Английский

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Paclitaxel alleviates spinal cord injury via activation of the Wnt/β-catenin signaling pathway

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: May 6, 2025

Language: Английский

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Identification of Autophagy-Related Genes in Patients with Acute Spinal Cord Injury and Analysis of Potential Therapeutic Targets

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 16, 2024

Language: Английский

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Lentiviral Injection of Inter-α-Trypsin Inhibitor Heavy Chain 4 Promotes Female Spinal Cord Injury Mice Recuperation by Diminishing Peripheral and Central Inflammation

Inflammation, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Language: Английский

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