Beilstein Journal of Nanotechnology,
Journal Year:
2024,
Volume and Issue:
15, P. 1619 - 1626
Published: Dec. 16, 2024
Biomimetic
nanocarriers,
engineered
to
mimic
the
characteristics
of
native
cells,
offer
a
revolutionary
approach
in
treatment
various
complex
human
diseases.
This
strategy
enhances
drug
delivery
by
leveraging
innate
properties
cellular
components,
thereby
improving
biocompatibility
and
targeting
specificity.
nanocarriers
demonstrate
significant
advancements
systems
against
cancer
therapy,
Alzheimer's
disease,
autoimmune
diseases,
viral
infections
such
as
COVID-19.
Here,
we
address
therapeutic
applications
biomimetic
their
promising
for
personalized
medicine.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(22), P. 1779 - 1779
Published: Nov. 5, 2024
As
nanocarriers
of
a
new
generation,
biomimetic
nanovesicles
are
an
emerging
class
therapeutic
tools
whose
surface
is
integrated
or
fabricated
with
biomaterials
capable
mimicking
the
biological
features
and
functions
native
cells.
Thanks
to
this,
nanovesicles,
in
particular,
those
made
by
plasma
membrane
moieties,
possess
greatly
improved
biocompatibility,
high
target
specificity,
long
retention
time,
minimal
undesired
immune
responses.
For
these
reasons,
multitude
progenitor
cells
including
cancer
ones
were
employed
as
templates
generate
membrane-camouflaged
hosting
different
compounds.
In
this
contribution,
membrane-derived
vesicles
(M-NVs)
generated
osmotic
lysis
isolation
approaches
from
normal
cell
lines
assayed
against
vitro
models
human
glioblastoma.
M-NVs
compared
their
cellular
internalization
degrees
DNA
proteins,
morphologically
molecularly
characterized,
expressing
extracellular
membrane-associated
marker.
Then,
Rose
Bengal
(RB),
photoactivable
drug
characterized
relatively
low
uptake,
was
incorporated
into
nascent
glioblastoma-derived
finally
administered
homotypic
receiving
cells,
showing
increased
degree
well
induced
cytotoxic
effects,
even
absence
photodynamic
direct
stimulation.
Similar
results
also
obtained
assaying
lyophilized
loaded
RB.
conclusion,
membranes
effectively
deliver
several
cargoes,
molecules,
maintain
functionality
after
lyophilization,
show
significant
making
them
promising
strategy
for
applications
glioblastoma
Beilstein Journal of Nanotechnology,
Journal Year:
2024,
Volume and Issue:
15, P. 1619 - 1626
Published: Dec. 16, 2024
Biomimetic
nanocarriers,
engineered
to
mimic
the
characteristics
of
native
cells,
offer
a
revolutionary
approach
in
treatment
various
complex
human
diseases.
This
strategy
enhances
drug
delivery
by
leveraging
innate
properties
cellular
components,
thereby
improving
biocompatibility
and
targeting
specificity.
nanocarriers
demonstrate
significant
advancements
systems
against
cancer
therapy,
Alzheimer's
disease,
autoimmune
diseases,
viral
infections
such
as
COVID-19.
Here,
we
address
therapeutic
applications
biomimetic
their
promising
for
personalized
medicine.
