A look at MERCs as UPRmt regulatory hubs in age-associated heart diseases
The Journal of Cardiovascular Aging,
Journal Year:
2025,
Volume and Issue:
5(1)
Published: Jan. 22, 2025
With
the
increase
in
life
expectancy
globally,
challenge
of
dealing
with
aging
becomes
more
prominent.
Aging
is
a
risk
factor
for
several
diseases,
including
cardiovascular
disease.
Mitochondria,
which
have
long
been
studied
relation
to
aging,
play
crucial
role
maintaining
cellular
homeostasis.
However,
there
limitation
interorganellar
communication
as
organisms
age.
The
unfolded
protein
response
mitochondria
(UPRmt)
activated
during
stress
maintain
mitochondrial
homeostasis
and
prevent
accumulation
damaged
mitochondria.
This
involves
signaling
from
nucleus,
leading
transcriptional
changes.
In
context
heart,
this
review
explores
terms
function
morphology.
It
also
discusses
impact
UPRmt
on
cardiac
diseases
such
heart
failure,
acute
myocardial
infarction,
dilated
cardiomyopathy.
highlights
potential
mitochondria-endoplasmic
reticulum
contact
sites
(MERCs)
modulating
aging.
Finally,
it
provides
an
update
molecules
that
induce
activity,
potentially
benefiting
Language: Английский
The multifaceted role of mitochondria in cardiac function: insights and approaches
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 29, 2024
Abstract
Cardiovascular
disease
(CVD)
remains
a
global
economic
burden
even
in
the
21st
century
with
85%
of
deaths
resulting
from
heart
attacks.
Despite
efforts
reducing
risk
factors,
and
enhancing
pharmacotherapeutic
strategies,
challenges
persist
early
identification
progression
functional
recovery
damaged
hearts.
Targeting
mitochondrial
dysfunction,
key
player
pathogenesis
CVD
has
been
less
successful
due
to
its
role
other
coexisting
diseases.
Additionally,
it
is
only
organelle
an
agathokakological
function
that
remedy
poison
for
cell.
In
this
review,
we
describe
origins
cardiac
mitochondria
heteroplasmy
subpopulations
namely
interfibrillar,
subsarcolemmal,
perinuclear,
intranuclear
maintaining
disease-associated
remodeling.
The
cumulative
evidence
retrograde
communication
nucleus
addressed,
highlighting
need
study
genotype-phenotype
relationships
specific
functions
by
using
approaches
like
genome-wide
association
(GWAS).
Finally,
discuss
practicality
computational
methods
combined
single-cell
sequencing
technologies
address
genetic
screening
contributory
genes
towards
CVD.
Language: Английский