Cited by Application of mesenchymal stem cells in liver fibrosis and regeneration

Current Updates, Recent Trends and Future Directions of Gene Therapy on Various Eye Disorders DOI

Saeed Ur Rehman,

Umar Javed,

Ammara Saleem

et al.

Indus journal of bioscience research., Journal Year: 2025, Volume and Issue: 3(1), P. 500 - 508

Published: Jan. 29, 2025

Gene therapy has emerged as a novel strategy in the treatment of eye problems, bringing fresh hope for illnesses previously believed to be untreatable. Recent developments molecular biology and genetic engineering have enabled creation tailored medicines that address fundamental causes ocular rather than just treating symptoms. interventions are showing promise conditions including diabetic retinopathy, age-related macular degeneration, hereditary retinal dystrophies. The area undergone revolution because methods like CRISPR-Cas9 gene editing adeno-associated viral (AAV) vectors, which enable precise delivery change material within protected limited environment eye. Patients receiving these treatments shown notable increases visual acuity structural repair clinical studies. Furthermore, order overcome obstacles immunogenicity payload capacity, next-generation systems nanoparticles non-viral vectors emerging, could increase potential therapy. Although field is still developing quickly, ethical concerns, high expenses, requirement long-term safety assessments major problems. This review highlights latest disorders, discussing key breakthroughs, ongoing trials, future directions achieve widespread accessibility efficacy diseases.

Language: Английский

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Kanglexin, a New Anthraquinone Compound, Inhibits Hepatic Fibrosis by Regulating Glutathione Metabolism with Pck1-Mediated Gluconeogenesis DOI

Weibing Kou,

Qiaohui Liu,

Yaping Guo

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

Nanoparticle: Pathogenesis, Innovative Diagnosis, and Therapy of Liver Fibrosis DOI

Wen Lin, X Liu,

Dejun Yang

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(7)

Published: Feb. 1, 2025

Abstract Liver fibrosis, a progressive condition resulting from chronic liver injury, can lead to cirrhosis and hepatocellular carcinoma. Nanoparticles have emerged as promising tools for their diagnosis treatment due unique properties. This review highlights advances in lipid‐based (e.g., liposomes, solid lipid nanoparticles), polymer‐based nanocapsules, dendrimers), inorganic iron oxide, gold biological nanoparticles extracellular vesicles, exosomes). These enhance imaging contrast MRI CT, enabling non‐invasive fibrosis detection, deliver drugs or gene‐editing hepatic stellate cells (HSCs) targeted therapy. Extracellular vesicles (EVs) exosomes also show potential biomarkers therapeutic carriers. However, challenges such limited targeting efficiency, toxicity, difficulties clinical translation remain. Future research should focus on optimizing nanoparticle design, improving biocompatibility, addressing regulatory issues facilitate application. Nanoparticle‐based strategies hold great promise revolutionizing management.

Language: Английский

Citations

Application of mesenchymal stem cells in liver fibrosis and regeneration DOI

Zhenyu Liu,

Junkai Ren,

Cheng Qiu

et al.

Liver Research, Journal Year: 2024, Volume and Issue: 8(4), P. 246 - 258

Published: Nov. 26, 2024

Language: Английский

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