Ferroptosis in senescence and age-related diseases: pathogenic mechanisms and potential intervention targets

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 17, 2025

Language: Английский

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Advances in Ferroptosis Research: A Comprehensive Review of Mechanism Exploration, Drug Development, and Disease Treatment

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 334 - 334

Published: Feb. 26, 2025

In recent years, ferroptosis, as an emerging modality of programmed cell death, has captured significant attention within the scientific community. This comprehensive review meticulously canvasses pertinent literature past few spanning multiple facets. It delves into intricate mechanisms underpinning tracks evolution its inducers and inhibitors, dissects roles in a diverse array diseases, well resultant therapeutic implications. A profound exploration is conducted functional ferroptosis-related molecules, intracellular pathways, metabolic cascades, signaling transduction routes. Novel ferroptosis inhibitors are introduced detail, covering their design blueprints, synthetic methodologies, bioactivity profiles. Moreover, exhaustive account provided regarding involvement malignancies, neurodegenerative disorders, cardiovascular ailments, other pathologies. By highlighting pivotal status potential regimens various this aspires to furnish thorough reference framework for future investigations clinical translations domain.

Language: Английский

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Berberine inhibits prostate cancer progression by inducing ferroptosis: evidence from network pharmacology

Anti-Cancer Drugs, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

The uncertain ferroptosis-related role of berberine in prostate cancer was explored using network pharmacology methodology. Integration ferroptosis targets from the Genecard database and Traditional Chinese Medicine Systems Pharmacology SwissTargetPrediction databases revealed 17 common targets. Among these, 10 hub genes, including CCNB1 , CDK1 AURKA AR CDC42 ICAM1 TYMS NTRK1 PTGS 2, SCD were identified. Enrichment analyses yielded 799 Gene Ontology terms 23 Kyoto Encyclopedia Genes Genomes pathways associated with berberine-related Molecular docking simulations indicated berberine’s binding capacity to all genes. In-vitro studies on LNCaP PC3 cells demonstrated inhibition cell proliferation significant downregulation both lines. Berberine exhibited line-specific effects by reducing expression suppressing cells. Overall, shows promise inhibiting progression through modulation .

Language: Английский

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Identification of compounds against atherosclerosis induced by ox-LDL based on cell extraction/UPLC–MS/MS from mulberry twigs and their mechanistic analysis

Chemical and Biological Technologies in Agriculture, Journal Year: 2025, Volume and Issue: 12(1)

Published: Jan. 15, 2025

Mulberry twigs, a traditional Chinese medicinal and agricultural byproduct, contain bioactive compounds with anti-atherosclerotic potential. This study aims to identify evaluate the effects of key in mulberry twig extracts (MTEs) on oxidized low-density lipoprotein (ox-LDL)-induced human umbilical vein endothelial cells (HUVECs), focus understanding how these modulate oxidative stress related signaling pathways. Biospecific cell extraction ultra-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) were employed screen compounds. Protective assessed by measuring viability, malondialdehyde (MDA), superoxide dismutase (SOD) levels, along detecting intracellular reactive oxygen species (ROS) using 2, 7-dichlorodihydrofluorescein diacetate (DCFH-DA) dihydroethidine (DHE) probes. Real-time qPCR Western blotting used for mRNA protein level analysis. Two novel active compounds, Kuwanon H Morusin, known G, identified. They significantly reduced MDA ROS levels while increasing SOD activity ox-LDL-treated HUVECs. was particularly effective, enhancing nuclear factor erythroid 2-related 2 (Nrf-2) upregulating its target genes Heme oxygenase-1 (HO-1) NAD(P)H: quinone oxidoreductase 1 (NQO-1). In conclusion, H, G effectively protected HUVECs from ox-LDL-induced injury, showing strongest protective via Nrf-2/HO-1 pathway. These hold potential treating atherosclerosis diseases.

Language: Английский

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Ferroptosis, pathogenesis and therapy in AS co-depression disease

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

Atherosclerosis (AS)-related cardiovascular disease and depression are often comorbid, with patients facing an increased risk of depression, which worsens AS. Both diseases characterized by oxidative stress lipid metabolism disorders. Ferroptosis, a form cell death iron overload harmful peroxide accumulation, is found in various diseases, including AS depression. Consistent the deposition peroxidation (LPO) that characterize ferroptosis mechanism, disturbances also crucial pathogenic mechanisms The comorbid complex, posing challenges for clinical treatment. Chinese herbs hold significant potential owing to their multi-target pharmacological effects. Therefore, this review aims investigate overload, LPO, across types, shared pathogenesis ferroptosis, research on herbal medicine targeting treatment anti-AS co-depression. This provides comprehensive understanding co-depression from perspective ferroptosis.

Language: Английский

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Spermine delivered by ZIF90 nanoparticles alleviates atherosclerosis by targeted inhibition of macrophage ferroptosis in plaque

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 4, 2025

Nowadays, emerging evidence have suggested that the ferroptosis of macrophages could contribute to progression atherosclerosis (AS). Meanwhile, Spermine (Sp) serve as an endogenous small molecule exhibiting a wide range cardiovascular protective effects. Zeolitic imidazolate framework-90 (ZIF90) nanoparticles were synthesized and utilized create novel delivery nanosystem encapsulated with Sp (CD16/32-ZIF90@Sp). The efficacy CD16/32-ZIF90@Sp in protecting against AS was evaluated ApoE-/- mice macrophages, focus on assessing potential adverse effects vivo. exhibited reliable stable within acidic environments ATP sensitivity. effectively reduced cytotoxicity Sp. As is evidenced by vitro vivo experiments, showed precise targeting atherosclerotic plaques ox-LDL-activated macrophages. Furthermore, treatment attenuated macrophage plaque without causing significant side Mechanistically, we found inhibited via improving mitochondrial function upregulating expression level GPX4/xCT. Our study demonstrated CD16/32-modified ZIF90 target plaques, leading inhibition mice. These attributed enhancement ferroptosis, limited

Language: Английский

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Phospholipid metabolism and drug resistance in cancer

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123626 - 123626

Published: April 1, 2025

Language: Английский

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Obesity: pathophysiology and therapeutic interventions

Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)

Published: April 25, 2025

Abstract Over the past few decades, obesity has transitioned from a localized health concern to pressing global public crisis affecting over 650 million adults globally, as documented by WHO epidemiological surveys. As chronic metabolic disorder characterized pathological adipose tissue expansion, inflammation, and neuroendocrine dysregulation that disrupts systemic homeostasis impairs physiological functions, is rarely an isolated condition; rather, it frequently complicated severe comorbidities collectively elevate mortality risks. Despite advances in nutritional science initiatives, sustained weight management success rates prevention remain limited, underscoring its recognition multifactorial disease influenced genetic, environmental, behavioral determinants. Notably, escalating prevalence of earlier onset younger populations have intensified urgency develop novel therapeutic agents simultaneously ensure efficacy safety. This review aims elucidate pathophysiological mechanisms underlying obesity, analyze major complications—including type 2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), non-alcoholic fatty liver (NAFLD), obesity-related respiratory disorders, nephropathy (ORN), musculoskeletal impairments, malignancies, psychological comorbidities—and critically evaluate current anti-obesity strategies. Particular emphasis placed on emerging pharmacological interventions, exemplified plant-derived natural compounds such berberine (BBR), with focus their molecular mechanisms, clinical efficacy, advantages. By integrating mechanistic insights evidence, this seeks provide innovative perspectives for developing safe, accessible, effective treatments.

Language: Английский

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Targeting lipid droplets and lipid droplet-associated proteins: a new perspective on natural compounds against metabolic diseases

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Sept. 4, 2024

Language: Английский

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Berberine Targets PKM2 to Activate the t-PA-Induced Fibrinolytic System and Improves Thrombosis

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(9), P. 1219 - 1219

Published: Sept. 17, 2024

Arterial thrombosis, a condition in which thrombi form arteries, can lead to various acute cardiovascular diseases and impact the quality of life survival patients. Berberine (BBR), quaternary ammonium alkaloid, has been shown treat these diseases. However, further exploration is needed understand underlying mechanisms BBR.

Language: Английский

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