The Enigmatic Role of SIRT2 in the Cardiovascular System: Deciphering its Protective and Detrimental Actions to Unlock New Avenues for Therapeutic Intervention DOI
Abdulaziz Hassan Alhasaniah, Mohammed Alissa, Fahmy G. Elsaid

et al.

Current Problems in Cardiology, Journal Year: 2024, Volume and Issue: unknown, P. 102929 - 102929

Published: Nov. 1, 2024

Language: Английский

Vascular endothelial cell injury: causes, molecular mechanisms, and treatments DOI Creative Commons
Tian Xia,

Jiachi Yu,

Meng Du

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(2)

Published: Jan. 16, 2025

Vascular endothelial cells form a single layer of flat that line the inner surface blood vessels, extending from large vessels to microvasculature various organs. These are crucial metabolic and endocrine components body, playing vital roles in maintaining circulatory stability, regulating vascular tone, preventing coagulation thrombosis. Endothelial cell injury is regarded as pivotal initiating factor pathogenesis diseases, triggered by multiple factors, including infection, inflammation, hemodynamic changes, which significantly compromise integrity function. This review examines causes, underlying molecular mechanisms, potential therapeutic approaches for injury, focusing specifically on damage cardiac ischemia/reperfusion (I/R) sepsis, diabetes. It delves into intricate signaling pathways involved emphasizing oxidative stress, mitochondrial dysfunction, inflammatory mediators, barrier damage. Current treatment strategies-ranging pharmacological interventions regenerative lifestyle modifications-face ongoing challenges limitations. Overall, this highlights importance understanding within context diseases necessity innovative methods improve patient outcomes.

Language: Английский

Citations

1
IRF-1 promotes diabetic vasculopathy by mediating endothelial cell pyroptosis DOI

Yande Zhou,

Zhihua Liu, Yun Xu

et al.

Annals of Vascular Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
The comprehensive review of eucalyptol: synthesis, metabolism, and therapeutic applications in disease treatment DOI

Bin Yao,

Bin He, Jiahua Peng

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: March 28, 2025

Language: Английский

Citations

0
1,8-Cineole ameliorates vascular endothelial senescence in diabetes mellitus by directly targeting and deubiquitinating PPAR-γ in vivo and in vitro DOI Creative Commons

Lingyun Fu,

Shidie Tai,

Jiajia Liao

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101307 - 101307

Published: April 1, 2025

Language: Английский

Citations

0
Alendronate sodium induces G1 phase arrest and apoptosis in human umbilical vein endothelial cells by inhibiting ROS-mediated ERK1/2 signaling DOI
Yi Feng, Shaoqin Tu,

Yuluan Hou

et al.

Toxicology, Journal Year: 2024, Volume and Issue: 508, P. 153917 - 153917

Published: Aug. 11, 2024

Language: Английский

Citations

1
The Enigmatic Role of SIRT2 in the Cardiovascular System: Deciphering its Protective and Detrimental Actions to Unlock New Avenues for Therapeutic Intervention DOI
Abdulaziz Hassan Alhasaniah, Mohammed Alissa, Fahmy G. Elsaid

et al.

Current Problems in Cardiology, Journal Year: 2024, Volume and Issue: unknown, P. 102929 - 102929

Published: Nov. 1, 2024

Language: Английский

Citations

0