Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Nov. 26, 2024
Background
Sepsis
is
defined
as
a
dysregulated
host
response
to
infection
that
results
in
life-threatening
organ
dysfunction.
The
24-hour
urine
volume
plays
crucial
role
assessing
the
prognosis
of
septic
patients.
This
study
aims
investigate
relationship
between
and
28-day
intensive
care
unit
(ICU)
mortality
patients
exploring
dose-response
these
variables.
Methods
retrospective
cohort
analyzed
data
from
7,218
sepsis
eICU
Collaborative
Research
Database.
Logistic
regression
models
generalized
additive
were
used
examine
ICU
mortality.
Results
A
negative
correlation
was
found
In
fully
adjusted
model,
each
50
mL
increase
significantly
reduced
risk
by
1%
(OR
=
0.99,
95%
CI
0.98–0.99,
P
<
0.001).
nonlinear
observed,
with
an
inflection
point
at
~1,663.5
ml.
Below
this
threshold,
increased
associated
0.97,
CI:
0.96–0.98,
0.001),
while
above
point,
not
statistically
significant.
Conclusion
demonstrates
non-linear
Tissue Barriers,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 16, 2025
Vascular
endothelial
barrier
disruption
is
a
critical
determinant
of
morbidity
and
mortality
in
sepsis.
Whole
blood
represents
key
source
paracrine
signaling
molecules
inducing
vascular
This
study
analyzes
whole-genome
transcriptome
data
from
sepsis
patients'
whole
available
the
NCBI
GEO
database
to
identify
mediators
dysfunction,
uncovering
novel
insights
that
may
guide
drug
repositioning
strategies.
identifies
regulated
expression
TFPI,
MMP9,
PROS1,
JAG1,
S1PR1,
S1PR5
which
either
disrupt
or
protect
function
could
serve
as
potential
targets
for
existing
drugs.
Specifically,
TFPI
(barrier
protective),
MMP9
destructive),
PROS1
JAG1
destructive)
are
upregulated,
while
S1PR1
protective)
downregulated.
Our
observations
highlight
importance
considering
both
protective
disruptive
development
therapeutic
strategies
restore
integrity
septic
patients.
Identifying
druggable
regulators
pave
way
precision
medicine
approaches,
enabling
personalized
treatments
target
specific
improve
patient
outcomes
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: May 22, 2025
Sepsis-induced
acute
lung
injury
(ALI)
and
respiratory
distress
syndrome
(ARDS)
are
severe
complications
with
high
morbidity
mortality
rates,
characterized
primarily
by
diffuse
alveolar
damage,
endothelial
dysfunction,
local
inflammatory
responses.
Neutrophils
cells
(ECs)
play
crucial
roles
in
the
pathogenesis
progression
of
these
diseases.
important
regulators
inflammation,
while
dysfunction
exacerbates
vascular
permeability
cascade.
The
interaction
between
neutrophils
ECs
is
vital
for
development
ALI/ARDS
induced
sepsis,
driving
pathological
processes
inflammation
tissue
damage.
Despite
advancements
treatment
strategies
such
as
protective
mechanical
ventilation
fluid
management,
effective
methods
rapid
recovery
or
significant
improvement
outcomes
remain
lacking.
Therefore,
we
comprehensively
summarize
current
literature
to
gain
deeper
insights
into
neutrophils,
ECs,
their
interactions
sepsis-induced
ALI/ARDS,
hoping
provide
critical
mechanisms
underlying
sepsis-related
potential
pathways
developing
new
therapeutic
approaches.
Environmental Toxicology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 9, 2024
ABSTRACT
Acute
lung
injury
(ALI)
is
a
difficult
condition
to
manage,
especially
when
it
complicated
by
bacterial
sepsis.
Hibifolin,
flavonoid
glycoside,
has
anti‐inflammatory
properties
that
make
potential
treatment
for
ALI.
However,
more
research
needed
determine
its
effectiveness
in
LPS‐induced
In
this
study,
male
ICR
mice
were
treated
with
hibifolin
before
Protein
content
and
neutrophil
count
bronchoalveolar
lavage
(BAL)
fluid
measured
BCA
assay
Giemsa
staining
method,
respectively.
The
levels
of
proinflammatory
cytokines
adhesive
molecules
detected
ELISA
assay.
expression
NFκB
p65
phosphorylation,
IκB
degradation,
Akt
phosphorylation
was
assessed
western
blot
Hibifolin
pre‐treatment
significantly
reduced
pulmonary
vascular
barrier
dysfunction
infiltration
into
the
BAL
ALI
mice.
addition,
(IL‐1β,
IL‐6,
TNF‐α)
(ICAM‐1,
VCAM‐1)
within
markedly
More,
inhibited
p65,
degradation
IκB,
lungs
conclusion,
shows
promise
improving
pathophysiological
features
responses
through
pathway
upstream
factor,
phosphorylation.
Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Nov. 26, 2024
Background
Sepsis
is
defined
as
a
dysregulated
host
response
to
infection
that
results
in
life-threatening
organ
dysfunction.
The
24-hour
urine
volume
plays
crucial
role
assessing
the
prognosis
of
septic
patients.
This
study
aims
investigate
relationship
between
and
28-day
intensive
care
unit
(ICU)
mortality
patients
exploring
dose-response
these
variables.
Methods
retrospective
cohort
analyzed
data
from
7,218
sepsis
eICU
Collaborative
Research
Database.
Logistic
regression
models
generalized
additive
were
used
examine
ICU
mortality.
Results
A
negative
correlation
was
found
In
fully
adjusted
model,
each
50
mL
increase
significantly
reduced
risk
by
1%
(OR
=
0.99,
95%
CI
0.98–0.99,
P
<
0.001).
nonlinear
observed,
with
an
inflection
point
at
~1,663.5
ml.
Below
this
threshold,
increased
associated
0.97,
CI:
0.96–0.98,
0.001),
while
above
point,
not
statistically
significant.
Conclusion
demonstrates
non-linear
