New insights into microbial bile salt hydrolases: from physiological roles to potential applications

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 12, 2025

Gut microbiota has been increasingly linked to metabolic health and diseases over the past few decades. Bile acids (BAs), major components of bile, are bidirectionally intestinal microbiota, also known as gut microbiome-BA axis. microbiota-derived bile salt hydrolase (BSH, EC 3.5.1.24), which catalyzes “gateway” reaction in a wider pathway acid modification, not only shapes landscape, but modulates crosstalk between host health. Therefore, microbial BSHs exhibit potential directly or indirectly influence physiologies, have considered promising targets for modulation benefit animal human However, their physiological functions bacterial physiologies still controversial clear. In this review, we mainly discuss current evidence related roles that played health, possible underlying mechanisms. Meanwhile, present applications BSH-producing probiotics various fields. Finally, describe several important questions need be addressed by further investigations. A detailed exploration significance will contribute future diagnostic therapeutic improving

Language: Английский

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Evaluating the causal effects of circulating metabolic biomarkers on Alzheimer's disease

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 138, P. 111309 - 111309

Published: March 2, 2025

Language: Английский

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Research Progress of Bile Acids in Neurodegenerative Diseases

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(02), P. 1718 - 1724

Published: Jan. 1, 2025

Language: Английский

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Nanobilosome as custom-tailored modality in addressing Alzheimer’s disease: advancements and translational glitches

Journal of Dispersion Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 32

Published: April 11, 2025

Language: Английский

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Long-Term Benefits of TUDCA Supplement in ARSACS Zebrafish Model

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is an early-onset neurodevelopmental and neurodegenerative disorder characterized by ataxia, spasticity, peripheral neuropathy. However, several studies have highlighted that some patients also experience cognitive, emotional social deficits, suggesting a more complex clinical picture extends beyond motor symptoms. Building on these findings, this study aimed to: i) investigate locomotor, cognitive deficits in adult sacs^-/- zebrafish versus wild-type (WT) controls through behavioural tests; ii) identify molecular patterns associated with the disease phenotype using transcriptomic proteomic analyses WT brains; iii) evaluate effectiveness long-term treatment tauroursodeoxycholic acid (TUDCA) outcomes omics profiles model. Our findings indicate impairments social, behaviors aged zebrafish, which resemble observed human patients. Transcriptomic brains identified alterations genes related to circadian rhythms neuroinflammation. Notably, disruptions sleep are frequently reported individuals cerebellar may contribute behavioral changes. Long-term TUDCA, neuroprotective molecule, was partial improvements modifications These results support potential further exploring TUDCA future preclinical studies, while emphasizing need for additional investigations better understand its mechanisms action.

Language: Английский

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A polygenetic rat model of divergent aerobic capacity reveals a liver–brain interaction impacting Alzheimer's disease‐like phenotypes

The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 11, 2025

Abstract The interaction between liver and brain health is an emerging complex relationship implicated in Alzheimer's disease (AD). Divergence aerobic capacity influences independently; however, whether these factors converge to influence AD risk mechanistically unknown. Bile acid metabolism has been as a link modulated by capacity. Here, we examined rats selectively bred for high vs . low intrinsic [high low‐capacity runner (HCR or LCR)] on indices of hepatic following chronic low‐fat, high‐fat, high‐fat diet with bile sequestrant from 6 12 months age. Pre‐ post‐diet measures included learning, memory, volume metabolite levels. We additionally quantified Aβ proteins associated production clearance, well mitochondrial energetics species. found that not only did function, but also it modified levels across the brain. Additionally, altered profiles hippocampal addition lowered sexually dimorphic manner. Aerobic cognitive outcomes. Our results indicate diet‐induced alterations modulate respect AD‐like pathologies, whereas stimulation faecal loss could have positive effects lowering Aβ. image Key points function alter species energy loss. both homeostasis. modulates metabolism. learning middle‐aged rats.

Language: Английский

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Compositional and functional gut microbiota alterations in mild cognitive impairment: links to Alzheimer’s disease pathology

Alzheimer s Research & Therapy, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 30, 2025

Language: Английский

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Zuojinwan ameliorates depressive-like behavior and gastrointestinal dysfunction in mice by modulating the FXR-bile acid-gut microbiota pathway

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: June 4, 2025

Zuojinwan (ZJW), a traditional herbal formulation, is widely applied in the management of depression and gastrointestinal dysfunction. However, its underlying mechanisms remain inadequately characterized. This study investigated antidepressant modulatory effects ZJW via bile acid–gut microbiota axis. A murine model exhibiting both depressive-like behavior disturbances was induced through chronic social defeat stress (CSDS). Antidepressant efficacy evaluated using battery behavioral assessments, while function assessed by measuring total transit time, colonic motility, gastric residual volume, small intestine propulsion rate. Bile acid (BA) levels brain, gut, serum were quantified UPLC-MS/MS, gut composition analyzed 16S rRNA sequencing. Histopathological examination Western blotting (WB) employed to assess tissue integrity FXR protein expression, respectively. markedly ameliorated depressive behaviors dysfunction, concurrently mitigating intestinal hippocampal neuronal damage. Treatment enhanced altered BA profiles, enriched microbial diversity. Notably, co-treatment with inhibitor (Z)-Guggulsterone diminished therapeutic ZJW, underscoring role signaling. These findings suggest that exerts benefits activating FXR, modulating metabolism, reshaping microbiota.

Language: Английский

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Effects of 28-Day Nose-Only Inhalation of PCB52 (2,2',5,5'-Tetrachlorobiphenyl) on the Brain Transcriptome

Toxicology, Journal Year: 2024, Volume and Issue: unknown, P. 153965 - 153965

Published: Oct. 1, 2024

Language: Английский

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