Digital Chinese Medicine, Journal Year: 2024, Volume and Issue: 7(4), P. 332 - 342
Published: Dec. 1, 2024
Language: Английский
Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 104, P. 102659 - 102659
Published: Jan. 10, 2025
Language: Английский
Citations
2
Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102680 - 102680
Published: Feb. 1, 2025
Language: Английский
Citations
2
Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2721 - 2721
Published: Aug. 15, 2024
Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin’s effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2256 documents, leading selection 15 clinical trials synthesis. Here, we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2121 - 2121
Published: Feb. 27, 2025
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by gradual decline in cognitive function. Currently, there are no effective treatments for this condition. Medicine food homology plants have gained increasing attention as potential natural AD because of their nutritional value and therapeutic benefits. In work, we aimed to provide deeper understanding how medicine may help alleviate or potentially treat identifying key targets, pathways, small molecule compounds from 10 that play an important role process. Using network pharmacology, identified 623 common targets between the selected plants, including crucial proteins such STAT3, IL6, TNF, IL1B. Additionally, molecules were grouped into four clusters using hierarchical clustering. The ConPlex algorithm was then applied predict binding capabilities these protein targets. Cluster 3 showed superior predicted IL1B, which further validated molecular docking. Scaffold analysis revealed those with steroid-like core-comprising three fused six-membered rings one five-membered ring carbon-carbon double bond-exhibited better affinities triple-target inhibitors. Among them, MOL005439, MOL000953, MOL005438 top-performing compounds. This study highlights source active could be developed new drugs treatment. However, pharmacokinetic studies essential assess efficacy minimize side effects.
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 133 - 133
Published: Jan. 20, 2025
Neuroinflammation is a key factor in the progression of neurodegenerative diseases, driven by dysregulation molecular pathways and activation brain’s immune system, resulting release pro-inflammatory oxidative molecules. This chronic inflammation exacerbated peripheral leukocyte infiltration into central nervous system. Medicinal plants, with their historical use traditional medicine, have emerged as promising candidates to mitigate neuroinflammation offer sustainable alternative for addressing conditions green healthcare framework. review evaluates effects medicinal plants on neuroinflammation, emphasizing mechanisms action, effective dosages, clinical implications, based systematic search databases such PubMed, SCOPUS, Web Science. The findings highlight that like Cleistocalyx nervosum var. paniala, Curcuma longa, Cannabis sativa, Dioscorea nipponica reduce cytokines (TNF-α, IL-6, IL-1β), inhibit enzymes (COX-2 iNOS), activate antioxidant pathways, particularly Nrf2. NF-κB primary pathway inhibited across studies. While anti-inflammatory potential these significant, variability dosages phytochemical compositions limits translation. Here, we are modulators underscoring therapeutic potential. Future research should focus animal models, standardized protocols, safety assessments, integrating advanced methodologies, genetic studies nanotechnology, enhance applicability disease management.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1207 - 1207
Published: Jan. 30, 2025
Nuclear receptors (NRs) are ligand-activated transcription factors that regulate a broad array of biological processes, including inflammation, lipid metabolism, cell proliferation, and apoptosis. Among the diverse family NRs, peroxisome proliferator-activated (PPARs), estrogen receptor (ER), liver X (LXR), farnesoid (FXR), retinoid (RXR), aryl hydrocarbon (AhR) have garnered significant attention for their roles in neurodegenerative diseases, particularly Alzheimer’s disease (AD). NRs influence pathophysiology AD through mechanisms such as modulation amyloid-beta (Aβ) deposition, regulation inflammatory pathways, improvement neuronal function. However, dual role progression, where some may exacerbate while others offer therapeutic potential, presents critical challenge application treatment. This review explores functional diversity highlighting involvement AD-related processes discussing prospects NR-targeting strategies. Furthermore, key challenges, necessity precise identification beneficial detailed structural analysis molecular dynamics simulations, further investigation NR AD, tau pathology autophagy, also discussed. Collectively, continued research is essential to clarify ultimately facilitating potential use diagnosis, prevention, treatment AD.
Language: Английский
Citations
0
Neuroprotection/Neuroprotection (Chichester, England. Print), Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
Abstract Recent evidence suggests a more important role of the gut microbiota in neurodegenerative diseases (NDDs) given its relationship through microbiota‐gut‐brain as an active communication system aiding maintaining homeostasis between brain and gut. This review focuses on how modulation can serves therapeutic strategy for NDDs, emphasizing neuroprotective effects probiotics. Probiotics are live microorganisms that confer health benefits, their interaction with gut‐microbiota influences neurogenesis, neurotransmitter regulation, neuroinflammation. advancements, including germ‐free animal models, fecal transplantation (FMT), diverse probiotic strains, have revealed underlying mechanisms linking to function. Notably, several Lactobacillus Bifidobacterium species been shown exert via upregulation neurotrophic factors such brain‐derived factor enhancing mitochondrial function reducing impacts oxidative stress. Interestingly, FMT has exhibited degree success overcoming cognitive impairment motor deficits preclinical studies clinical trials. However, further research is warranted explore potential humans. Overall, this highlights significant NDDs advocates gut‐targeted interventions innovative approaches mitigate these diseases.
Language: Английский
Citations
0
Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(3)
Published: March 1, 2025
Abstract Intermittent fasting (IF) is an eating pattern that promotes health and cognitive improvement through periodic eating. It has been shown to enhance neuroplasticity reduce oxidative stress inflammation. Recent studies have demonstrated probiotic supplementation enhances performance by modulating gut microbiota composition increasing short‐chain fatty acid production, which in turn neurogenesis synaptic plasticity. The microbiota‐gut‐brain axis (MGBA) the communication bridge between brain, influencing function immune, endocrine, nervous systems. combination of probiotics IF may exert complementary effects on function, with enhancing microbial diversity metabolic efficiency, while further modulate barrier integrity neurotransmitter synthesis. This review critically examines interplay via MGBA, identifying key mechanisms potential therapeutic strategies remain underexplored current research.
Language: Английский
Citations
0
Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(3)
Published: March 1, 2025
ABSTRACT Phytochemicals are bioactive compounds found in plants that play a key role promoting health and preventing diseases. Present fruits, vegetables, grains, seed oils, these considered safe for consumption due to the co‐evolution adaptation between mammals plants. Due their wide‐ranging biological effects, they have attracted considerable research interest. This comprehensive review explores mechanisms of action, benefits, applications dietary phytochemicals, with particular focus on groups such as polyphenols, flavonoids, carotenoids. Research shows phytochemicals interact nuclear membrane receptors, influence metabolic pathways, affect epigenetic modifications. Our highlights broad range activities compounds, including antioxidant, antibacterial, anti‐inflammatory, anti‐diabetic, anticancer all which contribute health‐promoting properties. Clinical evidence supports prevention management diseases cardiovascular disorders, conditions, cancer, diets rich being linked lower risk disease. also at cutting edge food preservation, supplements, emerging medical treatments. Additionally, we identified advancements extraction identification techniques, particularly metabolomics, further enhance areas. Despite promising challenges bioavailability, regulatory barriers, need robust clinical trials persist. However, innovative delivery systems like nanoparticles, liposomes, encapsulation offer potential solutions bioavailability by improving absorption stability. The concludes emphasizing personalized nutrition combination therapies benefits while stressing methods, trials, bioavailability.
Language: Английский
Citations
0
Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114537 - 114537
Published: March 1, 2025
Language: Английский
Citations
0