Advancing histological evaluation in IBD: New perspectives on Claudin-2 and mucosal healing

Digestive and Liver Disease, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Polyphenols mitigating inflammatory mechanisms in inflammatory bowel disease (IBD): focus on the NF-ƙB and JAK/STAT pathways

Inflammopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

The term "inflammatory bowel disease" (IBD) refers to a group of chronic inflammatory gastrointestinal disorders, which include ulcerative colitis and Crohn's disease. necessity for alternative therapeutic approaches is underscored by the fact that although present medicines are successful, they frequently result in considerable adverse effects. Naturally occurring substances included fruits vegetables called polyphenols have been shown capacity control important pathways including NF-κB JAK/STAT, essential pathophysiology IBD. processes polyphenols, such as curcumin, EGCG, resveratrol, quercetin, reduce inflammation examined this article. Polyphenols may advantages blocking synthesis cytokines activation immune cells targeting these pathways. Preclinical study indicates reduction intestinal inflammation, encouraging. However, more clinical research needed determine relevance therapy IBD, especially with regard their long-term safety bioavailability.

Language: Английский

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Laoxianghuang polysaccharide promotes the anti-inflammatory cytokine interleukin-10 in colitis via gut microbial linoleic acid

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156136 - 156136

Published: Oct. 9, 2024

Language: Английский

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Biological Response of Treatment with Saffron Petal Extract on Cytokine-Induced Oxidative Stress and Inflammation in the Caco-2/Human Leukemia Monocytic Co-Culture Model

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1257 - 1257

Published: Oct. 17, 2024

The pathogenesis of Inflammatory Bowel Disease (IBD) involves complex mechanisms, including immune dysregulation, gut microbiota imbalances, oxidative stress, and defects in the gastrointestinal mucosal barrier. Current treatments for IBD often have significant limitations adverse side effects, prompting a search alternative therapeutic strategies. Natural products with anti-inflammatory antioxidant properties demonstrated potential management. There is increasing interest exploring food industry waste as source bioactive molecules healthcare applications. In this study, co-culture system Caco-2 cells PMA-differentiated THP-1 macrophages was used to simulate human intestinal microenvironment. Inflammation induced using TNF-α IFN-γ, followed by treatment Saffron Petal Extract (SPE). results that SPE significantly attenuated stress inflammation downregulating expression pro-inflammatory mediators such iNOS, COX-2, IL-1β, IL-6 via modulation NF-κB pathway. Given key regulator macrophage-driven inflammation, our findings support further investigation complementary agent treatment.

Language: Английский

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Effects of water-insoluble wheat bran-fraction powder on disease activity and caecal microbiota in dextran sodium sulphate-induced inflammatory bowel disease mouse model

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Nov. 1, 2024

Language: Английский

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