Therapeutic prospects and potential mechanisms of Prdx6: as a novel target in musculoskeletal disorders DOI Creative Commons
Hongbin Sun, Chao Xu,

Zhilin Xiong

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

With the global population aging, musculoskeletal disorders (MSDs) have posed significant physical and psychological health challenges for patients as well a substantial economic burden on society. The advancements in conservative surgical interventions MSDs been remarkable recent years; however, current treatment modalities still fall short of meeting optimal requirements patients. Recently, peroxiredoxin 6 (Prdx6) has gained considerable attention from researchers due to its antioxidative, anti-inflammatory, anti-apoptotic properties. It found that Prdx6 is involved multiple system diseases, including MSDs; exact role lacking. This study aimed summarize structure, regulatory mechanism, potential function Prdx6. These findings may demonstrate novel target inhibiting advancement MSDs.

Language: Английский

Osteoarthritis is a risk factor for renal function injury based on the National Health and Nutrition Examination Survey and Mendelian Randomized study DOI Creative Commons

Liang Pang,

Kaichun Wu,

Yibo Zhu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 12, 2025

This study aims to investigate the association and causality between osteoarthritis (OA) chronic kidney disease (CKD) using data from National Health Nutrition Examination Survey (NHANES) Mendelian Randomization (MR) analysis. Participants with OA, urinary albumin, creatinine, albumin-to-creatinine ratio (UACR), blood estimated glomerular filtration rate (eGFR) were selected NHANES. CKD was calculated CKD-EPI equation, logistic regression assessed by OA-CKD association. A two-sample MR analysis conducted Genome-wide studies (GWAS) for hip OA (HOA), knee (KOA), acute renal failure (ARF), (CRF), cystatin C, serum creatinine (eGFRcrea), microalbuminuria. The inverse variance weighted (IVW) method used, heterogeneity, sensitivity, pleiotropy assessments. cross-sectional showed a significant positive [unadjusted OR: 2.398 (95% CI: 2.176-2.643), p < 0.001], which persisted after adjustment demographic factors, socioeconomic status, lifestyle medical history [adjusted 1.161 1.029-1.310), = 0.015]. revealed no causal relationship overall function markers but found genetic HOA C [IVW 0.0014, OR 1.02, 95% 1.01-1.03], KOA 0.0001, 1.06, 1.04-1.08]. Our indicates that are risk factors injury, providing new insights clinical management.

Language: Английский

Citations

0
Therapeutic prospects and potential mechanisms of Prdx6: as a novel target in musculoskeletal disorders DOI Creative Commons
Hongbin Sun, Chao Xu,

Zhilin Xiong

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

With the global population aging, musculoskeletal disorders (MSDs) have posed significant physical and psychological health challenges for patients as well a substantial economic burden on society. The advancements in conservative surgical interventions MSDs been remarkable recent years; however, current treatment modalities still fall short of meeting optimal requirements patients. Recently, peroxiredoxin 6 (Prdx6) has gained considerable attention from researchers due to its antioxidative, anti-inflammatory, anti-apoptotic properties. It found that Prdx6 is involved multiple system diseases, including MSDs; exact role lacking. This study aimed summarize structure, regulatory mechanism, potential function Prdx6. These findings may demonstrate novel target inhibiting advancement MSDs.

Language: Английский

Citations

0