Ferroptosis in diabetic cardiomyopathy: from its mechanisms to therapeutic strategies DOI Creative Commons

Meimei Tian,

Xinli Huang, Min Li

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 11, 2024

Diabetic cardiomyopathy (DCM) is defined as structural and functional cardiac abnormalities in diabetes, cardiomyocyte death the terminal event of DCM. Ferroptosis iron-dependent oxidative cell death. Evidence has indicated that iron overload ferroptosis play important roles pathogenesis Mitochondria, an organelle homeostasis ROS production, a crucial role diabetes. Studies have shown some anti-diabetic medicines, plant extracts, inhibitors might improve DCM by alleviating ferroptosis. In this review, we systematically reviewed evidence Anti-ferroptosis be promising therapeutic strategy for treatment

Language: Английский

Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal DOI Creative Commons

Seyed Mohammad Doodmani,

Payman Rahimzadeh,

Najma Farahani

et al.

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102059 - 102059

Published: Jan. 1, 2025

Language: Английский

Citations

0
LncRNA ENSSSCG00000035331 Alleviates Hippocampal Neuronal Ferroptosis and Brain Injury Following Porcine Cardiopulmonary Resuscitation by Regulating the miR‐let7a/GPX4 Axis DOI Creative Commons

Mao Zhang,

Wenbin Zhang, Ziwei Chen

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(4)

Published: April 1, 2025

ABSTRACT Background Following successful cardiopulmonary resuscitation, those survivors of cardiac arrest (CA) often suffer from severe brain injury, and the latter can result in significant mortality morbidity. Emerging evidence implicates that ferroptosis is involved pathogenesis post‐resuscitation its regulatory mechanisms remain to be investigated. Recently, some studies manifested long noncoding RNAs could critical regulators cell diverse ischemia–reperfusion injuries vital organs. This study was designed explore role mechanism a newly screened RNA ENSSSCG00000035331 alleviating hippocampal neuronal further investigate potential regulation by novel antioxidant sulforaphane. Methods Results Healthy male pigs mice were used establish models CA resuscitation vivo. A hypoxia/reoxygenation (H/R) model using primary porcine neurons constructed replicate injury vitro. We found expression significantly decreased impaired hippocampus sequencing analysis verification. Subsequently, overexpression reduced ferroptosis‐related ferrous iron reactive oxygen species production while markedly increased glutathione alleviated injury. Mechanistically, interacted with miR‐let7a, then inhibited binding peroxidase 4 (GPX4) mRNA finally promoted recovery latter's translation after H/R stimulation. In addition, sulforaphane treatment GPX4 miR‐let7a Conclusions Our findings highlighted regulator targeting miR‐let7a/GPX4 axis, additionally, might promising therapeutic agent for regulating signaling axis mentioned above.

Language: Английский

Citations

0
BAK ameliorated cerebral infarction/ischemia–reperfusion injury by activating AMPK/Nrf2 to inhibit TXNIP/NLRP3/caspase-1 axis DOI
Yuewei Xu,

Chang-Heng Yao,

Xiaoming Gao

et al.

Neuroscience Letters, Journal Year: 2024, Volume and Issue: 844, P. 138037 - 138037

Published: Nov. 6, 2024

Language: Английский

Citations

2
Ferroptosis in diabetic cardiomyopathy: from its mechanisms to therapeutic strategies DOI Creative Commons

Meimei Tian,

Xinli Huang, Min Li

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 11, 2024

Diabetic cardiomyopathy (DCM) is defined as structural and functional cardiac abnormalities in diabetes, cardiomyocyte death the terminal event of DCM. Ferroptosis iron-dependent oxidative cell death. Evidence has indicated that iron overload ferroptosis play important roles pathogenesis Mitochondria, an organelle homeostasis ROS production, a crucial role diabetes. Studies have shown some anti-diabetic medicines, plant extracts, inhibitors might improve DCM by alleviating ferroptosis. In this review, we systematically reviewed evidence Anti-ferroptosis be promising therapeutic strategy for treatment

Language: Английский

Citations

2