Emerging Ferroptosis Involvement in Amyotrophic Lateral Sclerosis Pathogenesis: Neuroprotective Activity of Polyphenols DOI Creative Commons

Annamaria Russo,

Stefano Putaggio,

Ester Tellone

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1211 - 1211

Published: March 8, 2025

Neurodegenerative diseases are a group of that share common features, such as the generation misfolded protein deposits and increased oxidative stress. Among them, amyotrophic lateral sclerosis (ALS), whose pathogenesis is still not entirely clear, complex neurodegenerative disease linked both to gene mutations affecting different proteins, superoxide dismutase 1, Tar DNA binding 43, Chromosome 9 open frame 72, Fused in Sarcoma, altered iron homeostasis, mitochondrial dysfunction, stress, impaired glutamate metabolism. The purpose this review highlight molecular targets ALS ferroptosis. Indeed, many pathways implicated hallmarks ferroptosis, recently discovered type iron-dependent programmed cell death characterized by reactive oxygen species (ROS) lipid peroxidation. Iron accumulation results dysfunction levels ROS, peroxidation, ferroptosis triggers; addition, inhibition Xc− system reduced cystine accumulation, leading excitotoxicity GPx4 synthesis. These potential involvement ALS, providing new biochemical could be exploited treatment using polyphenols.

Language: Английский

Sub-Chronic 30 mg/kg Iron Treatment Induces Spatial Cognition Impairment and Brain Oxidative Stress in Wistar Rats DOI

Karima Maaroufi,

Yassine Khadhraoui,

Afef Moulahi

et al.

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Language: Английский

Citations

0
Role of Copper and Zinc Ions in the Hydrolytic Degradation of Neurodegeneration-Related Peptides DOI Creative Commons
Valentina Pirota, Enrico Monzani, Simone Dell’Acqua

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 363 - 363

Published: Jan. 17, 2025

Spontaneous cleavage reactions normally occur in vivo on amino acid peptide backbones, leading to fragmentation products that can have different physiological roles and toxicity, particularly when the substrate of hydrolytic processes are neuronal peptides proteins highly related neurodegeneration. We report a study performed with HPLC-MS technique at temperatures (4 °C 37 °C) fragments (amyloid-β, tau, α-synuclein) conditions presence Cu2+ Zn2+ ions, two metal ions found millimolar concentrations amyloid plaques. The coordination these significantly protects their backbones toward degradation, preserving entire sequences over weeks solution, while free same buffer fully fragmented after or even shorter incubation period. Our data show is not only ruled by chemical sensitivity acids, but conformation changes induced influence reactions. enhanced stability provided increase local levels amyloidogenic species capable seeding fibril growth, resulting aberrant protein depositions deficits activity.

Language: Английский

Citations

0
Identifying potential genes driving ferroptosis in the substantia nigra and dopaminergic neurons in Parkinson's disease DOI
Arunaloke Chakrabarti, Sonia Verma

Molecular and Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 132, P. 103993 - 103993

Published: Jan. 21, 2025

Language: Английский

Citations

0
Blood-based biomarkers in mild behavioral impairment: an updated overview DOI Creative Commons
Efthalia Angelopoulou,

Xenia Androni,

Chiara Villa

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 6, 2025

Identifying individuals at-risk for dementia is one of the critical objectives current research efforts, highlighting need simple, cost-effective, and minimally invasive biomarkers. Mild behavioral impairment (MBI), characterized by emergence persistent neuropsychiatric manifestations in older adults, has attracted increasing attention as a potential early indicator cognitive decline dementia. A growing number studies have recently begun to explore relationship between MBI several blood-based biomarkers associated with Alzheimer's disease (AD) pathology, neurodegeneration, well systemic metabolic inflammatory dysregulation. In this context, been lower plasma Aβ42/Αβ40 ratio, higher phosphorylated tau at threonine 181 (p-tau181), increased neurofilament light chain (NfL) levels, disturbances markers, including homocysteine, insulin ferritin, suggesting multifaceted neurobiological basis syndrome. These findings offer insights into underlying pathophysiology MBI, connection symptoms progression AD. narrative review, we aim summarize critically discuss emerging literature evidence linking biomarkers, hoping shed more on MBI's pathophysiology, its AD-related neurobiology, practical utility predicting impairment, guiding interventions managing risk

Language: Английский

Citations

0
Diamagnetic Signature of Beta‐Amyloid (Aβ) and Tau (τ) Tangle Pathology in Alzheimer's Disease: A Review DOI Creative Commons
Sadegh Ghaderi, Sana Mohammadi, Farzad Fatehi

et al.

Aging Medicine, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 1, 2025

ABSTRACT The complex interplay between diamagnetic and paramagnetic substances within the brain, particularly in context of Alzheimer's disease (AD), offers a rich landscape for investigation using advanced quantitative neuroimaging techniques. Although conventional approaches have focused on properties iron, emerging promising research has highlighted significance signatures associated with beta‐amyloid (Aβ) plaques Tau (τ) protein aggregates. Quantitative susceptibility mapping (QSM) is post‐processing technique that visualizes characterizes these subtle alterations brain border tissue composition, such as gray–white matter interface. Through voxel‐wise separation contributions sources, QSM enabled identification quantification Aβ τ aggregates, even presence iron. However, several challenges remain utilizing clinical applications. These include relatively small magnitude signal compared to need high‐resolution imaging sophisticated analysis techniques, standardization acquisition protocols. Further necessary refine optimize parameters, develop robust pipelines improve sensitivity specificity detecting nature As our understanding continues evolve, expected play pivotal role advancing knowledge AD other neurodegenerative diseases.

Language: Английский

Citations

0
Emerging Ferroptosis Involvement in Amyotrophic Lateral Sclerosis Pathogenesis: Neuroprotective Activity of Polyphenols DOI Creative Commons

Annamaria Russo,

Stefano Putaggio,

Ester Tellone

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1211 - 1211

Published: March 8, 2025

Neurodegenerative diseases are a group of that share common features, such as the generation misfolded protein deposits and increased oxidative stress. Among them, amyotrophic lateral sclerosis (ALS), whose pathogenesis is still not entirely clear, complex neurodegenerative disease linked both to gene mutations affecting different proteins, superoxide dismutase 1, Tar DNA binding 43, Chromosome 9 open frame 72, Fused in Sarcoma, altered iron homeostasis, mitochondrial dysfunction, stress, impaired glutamate metabolism. The purpose this review highlight molecular targets ALS ferroptosis. Indeed, many pathways implicated hallmarks ferroptosis, recently discovered type iron-dependent programmed cell death characterized by reactive oxygen species (ROS) lipid peroxidation. Iron accumulation results dysfunction levels ROS, peroxidation, ferroptosis triggers; addition, inhibition Xc− system reduced cystine accumulation, leading excitotoxicity GPx4 synthesis. These potential involvement ALS, providing new biochemical could be exploited treatment using polyphenols.

Language: Английский

Citations

0