Recent Advances in Silica-Based Nanomaterials for Enhanced Tumor Imaging and Therapy DOI
Junjie Zhang, Zilu Liu, Zhijing Zhang

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(11), P. 7133 - 7169

Published: Nov. 4, 2024

Cancer remains a formidable challenge, inflicting profound physical, psychological, and financial burdens on patients. In this context, silica-based nanomaterials have garnered significant attention for their potential in tumor imaging therapy owing to exceptional properties, such as biocompatibility, customizable porosity, versatile functionalization capabilities. This review meticulously examines the latest advancements application of therapy. It underscores enhancing various cancer modalities, including fluorescence imaging, magnetic resonance computed tomography, positron emission ultrasound multimodal approaches. Moreover, delves into therapeutic efficacy chemotherapy, radiotherapy, phototherapy, immunotherapy, gas therapy, sonodynamic chemodynamic starvation gene Critical evaluations biosafety profiles degradation pathways these within biological environments are also presented. By discussing current challenges prospects, aims provide nuanced perspective clinical translation nanomaterials, thereby highlighting promise revolutionizing diagnostics, enabling real-time monitoring responses, advancing personalized medicine.

Language: Английский

STIMULI-RESPONSIVE SUPRAMOLECULAR HYDROGELS FOR PACLITAXEL DELIVERY: PROGRESS AND PROSPECTS DOI Creative Commons

Mohammad Qutub,

Amol Tatode, Jayshree Taksande

et al.

Aspects of Molecular Medicine, Journal Year: 2025, Volume and Issue: 5, P. 100062 - 100062

Published: Jan. 5, 2025

Citations

6
Targeting tumor microenvironment with RGD-functionalized nanoparticles for precision cancer therapy DOI Creative Commons
Sara Lorenzoni, Carlos Rodríguez‐Nogales, María J. Blanco‐Príeto

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217536 - 217536

Published: Feb. 1, 2025

Language: Английский

Citations

1
Oncogenic Mutations and the Tumor Microenvironment: Drivers of Non-Small Cell Lung Cancer Progression DOI Open Access
Achilleas Mitrakas,

Christos Kakouratos,

Ioannis Lamprou

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 853 - 853

Published: March 1, 2025

Non-small cell lung cancer (NSCLC) is a major cause of cancer-related deaths globally. The study focuses on understanding the interplay between genetic mutations, stem cells (CSCs), and tumor microenvironment (TME) in driving NSCLC progression, resistance to therapies, relapse. A systematic search was conducted PubMed Scopus databases identify significant valuable studies relevant NSCLC, focusing CSCs, TME. Articles were selected based their relevance, methodological severity, date publication, scientific soundness related biology therapeutic strategies. This review synthesized findings from these sources highlight key mechanisms potential interventions. Mutations critical genes KRAS, EGFR, TP53, other interfere with regulation, promoting CSC-like behavior, therapy, immune evasion. (TME), including cells, fibroblasts, extracellular matrix components, further supports growth reduction treatment efficacy. Promising strategies, CSC targeting, TME modulation, development novel biomarkers, have shown preclinical clinical studies. association alterations, TME, cellular pathways-including metabolism evasion-plays crucial role therapy resistance, highlighting need for comprehensive combination genomic profiling TME-targeting therapies could lead personalized approaches, offering hope better outcomes reduced mortality patients.

Language: Английский

Citations

1
Recent Advances in Silica-Based Nanomaterials for Enhanced Tumor Imaging and Therapy DOI
Junjie Zhang, Zilu Liu, Zhijing Zhang

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(11), P. 7133 - 7169

Published: Nov. 4, 2024

Cancer remains a formidable challenge, inflicting profound physical, psychological, and financial burdens on patients. In this context, silica-based nanomaterials have garnered significant attention for their potential in tumor imaging therapy owing to exceptional properties, such as biocompatibility, customizable porosity, versatile functionalization capabilities. This review meticulously examines the latest advancements application of therapy. It underscores enhancing various cancer modalities, including fluorescence imaging, magnetic resonance computed tomography, positron emission ultrasound multimodal approaches. Moreover, delves into therapeutic efficacy chemotherapy, radiotherapy, phototherapy, immunotherapy, gas therapy, sonodynamic chemodynamic starvation gene Critical evaluations biosafety profiles degradation pathways these within biological environments are also presented. By discussing current challenges prospects, aims provide nuanced perspective clinical translation nanomaterials, thereby highlighting promise revolutionizing diagnostics, enabling real-time monitoring responses, advancing personalized medicine.

Language: Английский

Citations

4