The physiological and pathogenic roles of yes-associated protein/transcriptional co-activator with PDZ-binding motif in bone or skeletal motor system-related cells

CytoJournal, Journal Year: 2025, Volume and Issue: 22, P. 13 - 13

Published: Feb. 8, 2025

Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the primary downstream effectors of Hippo signaling pathway. This pathway plays a crucial role in regulating organ size, maintaining tissue homeostasis, controlling cellular processes such as fate determination development. review provides an overview current understanding how regulators YAP TAZ contribute to physiological pathological tissues cells associated skeletal motor system. The underlying molecular mechanisms mechanical transduction were reviewed.

Language: Английский

Relationships among osteoporosis, redox homeostasis, and alcohol addiction: Importance of the brain-bone axis

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118063 - 118063

Published: April 19, 2025

Language: Английский