Umckalin Promotes Melanogenesis in B16F10 Cells Through the Activation of Wnt/β-Catenin and MAPK Signaling Pathways DOI Creative Commons

So-Yeon Oh,

Chang‐Gu Hyun

Applied Biosciences, Journal Year: 2025, Volume and Issue: 4(2), P. 20 - 20

Published: April 2, 2025

Melanogenesis is regulated by melanogenic enzymes such as tyrosinase (TYR), TRP-1, and TRP-2, whose expression controlled the microphthalmia-associated transcription factor (MITF). Various signaling pathways, including cAMP/PKA, MAPK/ERK, Wnt/β-catenin, PI3K/Akt, are involved in this process have been a focal point of research for treating pigmentation disorders. However, developing effective therapies conditions like vitiligo remains significant challenge. In study, effects umckalin on melanogenesis its molecular mechanisms were investigated using B16F10 cells, mouse melanoma cell line widely used model melanin production studies. cells produce via melanosomes express key TYR, making them reliable system. Our findings demonstrate that promotes concentration-dependent manner upregulating TRP-1 activating MITF pathway. Additionally, modulated GSK3β/β-catenin MAPK, to enhance melanogenesis. conclusion, enhances enzyme activity critical thereby promoting synthesis. These suggest could be promising candidate therapeutic agents disorders vitiligo. Further studies required explore clinical applications greater detail.

Language: Английский

Umckalin Promotes Melanogenesis in B16F10 Cells Through the Activation of Wnt/β-Catenin and MAPK Signaling Pathways DOI Creative Commons

So-Yeon Oh,

Chang‐Gu Hyun

Applied Biosciences, Journal Year: 2025, Volume and Issue: 4(2), P. 20 - 20

Published: April 2, 2025

Melanogenesis is regulated by melanogenic enzymes such as tyrosinase (TYR), TRP-1, and TRP-2, whose expression controlled the microphthalmia-associated transcription factor (MITF). Various signaling pathways, including cAMP/PKA, MAPK/ERK, Wnt/β-catenin, PI3K/Akt, are involved in this process have been a focal point of research for treating pigmentation disorders. However, developing effective therapies conditions like vitiligo remains significant challenge. In study, effects umckalin on melanogenesis its molecular mechanisms were investigated using B16F10 cells, mouse melanoma cell line widely used model melanin production studies. cells produce via melanosomes express key TYR, making them reliable system. Our findings demonstrate that promotes concentration-dependent manner upregulating TRP-1 activating MITF pathway. Additionally, modulated GSK3β/β-catenin MAPK, to enhance melanogenesis. conclusion, enhances enzyme activity critical thereby promoting synthesis. These suggest could be promising candidate therapeutic agents disorders vitiligo. Further studies required explore clinical applications greater detail.

Language: Английский

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