The Role of Hydrogen Sulfide in the Regulation of the Pulmonary Vasculature in Health and Disease
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(3), P. 341 - 341
Published: March 14, 2025
The
gasotransmitter
hydrogen
sulfide
(H2S;
also
termed
sulfide)
generally
acts
as
a
vasodilator
in
the
systemic
vasculature
but
causes
paradoxical
constriction
of
pulmonary
arteries
(PAs).
In
light
evidence
that
fall
partial
pressure
oxygen
(pO2)
increases
cellular
levels,
it
was
proposed
rise
artery
smooth
muscle
cells
(PASMCs)
is
responsible
for
hypoxic
vasoconstriction,
contraction
PAs
which
develops
rapidly
lung
regions
undergoing
alveolar
hypoxia.
contrast,
hypertension
(PH),
sustained
elevation
(PAP)
can
develop
presence
diverse
array
pathological
stimuli,
including
chronic
hypoxia,
associated
with
decrease
expression
-producing
enzymes
PASMCs
and
corresponding
production
by
lung.
Evidence
PAP
animal
models
PH
be
lowered
administration
exogenous
has
led
to
an
interest
using
sulfide-donating
agents
treating
this
condition
humans.
Notably,
intracellular
H2S
exists
equilibrium
other
sulfur-containing
species
such
polysulfides
persulfides,
these
reactive
sulfur
are
thought
mediate
most
its
effects
on
through
persulfidation
cysteine
thiols
proteins,
leading
changes
function
manner
similar
thiol
oxidation
species.
This
review
sets
out
what
currently
known
about
mechanisms
related
exert
their
actions
vascular
tone,
both
acutely
chronically,
discusses
potential
sulfide-releasing
drugs
treatments
different
types
arise
Language: Английский
Epigenetic Control of Alveolar Macrophages: Impact on Lung Health and Disease
Cells,
Journal Year:
2025,
Volume and Issue:
14(9), P. 640 - 640
Published: April 25, 2025
Alveolar
macrophages
(AMs)
are
immune
cells
located
in
the
alveoli—the
tiny
air
sacs
lungs
where
gas
exchange
occurs.
Their
functions
regulated
by
various
epigenetic
mechanisms,
which
essential
for
both
healthy
lung
function
and
disease
development.
In
lung’s
microenvironment,
AMs
play
critical
roles
surveillance,
pathogen
clearance,
tissue
repair.
This
review
examines
how
regulation
influences
AM
their
involvement
diseases.
Key
such
as
DNA
methylation,
histone
modifications,
non-coding
RNAs,
regulate
gene
expression
response
to
environmental
signals.
lungs,
these
modifications
enable
quickly
respond
inhaled
threats.
However,
when
processes
malfunction,
they
could
contribute
diseases
pulmonary
fibrosis,
COPD,
hypertension.
By
exploring
changes
affect
polarization,
plasticity,
responses,
we
can
gain
deeper
insights
into
role
open
new
avenues
treating
preventing
respiratory
conditions.
Ultimately,
understanding
mechanisms
within
enhances
our
knowledge
of
immunology
offers
potential
innovative
interventions
restore
health
prevent
Language: Английский