Dysfunctional cardiomyocyte signalling and heart disease DOI Creative Commons

Zara Ridgway,

Xuan Li

Current Opinion in Cell Biology, Journal Year: 2025, Volume and Issue: 94, P. 102517 - 102517

Published: April 17, 2025

Cardiomyocyte signalling pathways are central to maintaining the structural and functional integrity of heart. Dysregulation these contributes onset progression heart diseases, including failure, arrhythmias cardiomyopathies. This review focuses on very recent work dysfunctional cardiomyocyte its role in pathophysiology disease. We discuss key pathways, immune within cardiomyocytes, associated with microtubule dysfunction, Hippo-yes-associated protein adenosine monophosphate-activated kinase signalling, highlighting how aberrations their regulation lead impaired functions pinpointing potential therapeutic opportunities pathways. underscores complexity networks emphasises need for further dissecting prevent dysfunction.

Language: Английский

Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health DOI Creative Commons
Efthalia Moustakli,

Sofoklis Stavros,

Periklis Katopodis

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(1), P. 36 - 36

Published: Jan. 2, 2025

Chronic inflammation is increasingly recognized as a critical factor in female reproductive health; influencing natural conception and the outcomes of assisted technologies such vitro fertilization (IVF). An essential component innate immunity, NLR family pyrin domain-containing 3 (NLRP3) inflammasome one major mediators inflammatory responses, its activation closely linked to oxidative stress. This interaction contributes decline oocyte quality, reduced potential, impaired embryo development. In ovarian milieu, stress NLRP3 interact intricately, their combined effects on competence are significant. The aims this review examine these molecular mechanisms explore therapeutic strategies targeting activity, with goal enhancing fertility improving clinical health.

Language: Английский

Citations

0
Active ingredients of traditional Chinese medicine inhibit NOD-like receptor protein 3 inflammasome: a novel strategy for preventing and treating heart failure DOI Creative Commons

Ruifang Lin,

Yunfeng Yu,

Lixin Du

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

Heart failure (HF) has emerged as a significant global public health challenge owing to its high rates of morbidity and mortality. Activation the NOD-like receptor protein 3 (NLRP3) inflammasome is regarded pivotal factor in onset progression HF. Therefore, inhibiting activation NLRP3 may represent promising therapeutic approach for preventing treating The active ingredients serve foundation effects traditional Chinese medicine (TCM). Recent research revealed advantages TCM enhancing cardiac structure function study aimed explore impact on HF, review current advancements utilizing inhibit This provides novel perspective future development precise intervention strategies targeting prevent treat

Language: Английский

Citations

0
Macrophage and cardiomyocyte roles in cardioprotection: Exploiting the NLRP3 Inflammasome inhibitor INF150 DOI Creative Commons
Magalì Giordano, Saveria Femminò, Federica Blua

et al.

Vascular Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 107487 - 107487

Published: March 1, 2025

Language: Английский

Citations

0
Dysfunctional cardiomyocyte signalling and heart disease DOI Creative Commons

Zara Ridgway,

Xuan Li

Current Opinion in Cell Biology, Journal Year: 2025, Volume and Issue: 94, P. 102517 - 102517

Published: April 17, 2025

Cardiomyocyte signalling pathways are central to maintaining the structural and functional integrity of heart. Dysregulation these contributes onset progression heart diseases, including failure, arrhythmias cardiomyopathies. This review focuses on very recent work dysfunctional cardiomyocyte its role in pathophysiology disease. We discuss key pathways, immune within cardiomyocytes, associated with microtubule dysfunction, Hippo-yes-associated protein adenosine monophosphate-activated kinase signalling, highlighting how aberrations their regulation lead impaired functions pinpointing potential therapeutic opportunities pathways. underscores complexity networks emphasises need for further dissecting prevent dysfunction.

Language: Английский

Citations

0